| Project/Area Number |
24592822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAMI Masamichi 昭和大学, 歯学部, 教授 (80307058)
NAKAMURA Hiroaki 松本歯科大学, 歯学部, 教授 (50227930)
HAGIWARA Hiromi 桐蔭横浜大学, 医用工学部, 教授 (90189465)
HAYASHI Nobuhiro 東京工業大学, 生命理工学研究科, 准教授 (80267955)
BANDO Masashige 東京大学, 分子細胞生物学研究所, 助教 (90360627)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ABC輸送体 / 骨代謝 / 破骨細胞 |
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| Outline of Final Research Achievements |
We have been studying about the relationship between physiology of osteoclasts and function of ABC transporters. Since our previous studies have found that mRNA expression levels of 28 ABC transporters were increased during osteoclastgenesis, we investigated the function of the transporters by using knockout mice in the present study. Interestingly, Abcb4 and Abcc5 were found to regulate bone homeostasis, which were sex-dependent. These results suggest that ABC transporter can regulate bone homeostasis.
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