Analysis of a balance between pro-inflammatory and anti-inflammatory pulpal responses in the pathogenesis of pulpitis
| Project/Area Number |
24592871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKANISHI Tadashi 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (00217770)
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| Co-Investigator(Kenkyū-buntansha) |
YUMOTO Hiromichi 徳島大学, 病院, 講師 (60284303)
HOSOKAWA Yoshitaka 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (90346601)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯髄炎 / 歯髄細胞 / サイトカイン / 歯髄 / 炎症 / 象牙芽細胞 / リンパ球 |
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| Outline of Final Research Achievements |
With advance of dental caries, the infiltration of effecter T cells and the production of various inflammatory mediators such as prostaglandin (PG) in the dental pulp tissue become apparent. In this study, we evaluated the role of a balance between pro-inflammatory and anti-inflammatory responses in the pathogenesis of pulpitis using dental pulp cells. As a result, interleukin-17 from effecter T cells induced the production of cytokines such as CXCL10 and CCL20 in the dental pulp cells. In contrast, PGF2α up-regulated CCL20 production and down-regulated CXCL10 production in the activated dental pulp cells.
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Report
(4 results)
Research Products
(7 results)
