| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Iinvestigated the modulatory effects of use of a sensory trick on dystonic abnormal muscles activities and related activation of primary sensorimotor cortex in patients with oromandibular dystonia. Abnormal oromandibular dystonic muscle activities and related primary sensorimotor cortex activities were decreased by placing candy in the mouth. Furthermore, injection of botulinum toxin into the area of oromandibular dystonia led to significantly decreased abnormal oromandibular dystonic muscle activities and related primary cortex activation, as well as improvements in non-motor symptoms such as pain awareness and depressive mood state. Our findings indicate that both sensory trick and botulinum toxin injection modulate cortical activities related to oromandibular dystonia. In addition, such an injection improves both motor and non-motor symptoms in affected patients.
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