| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The aim of this study was to evaluate identification of Sjogren's syndrome-associated antigens using heterozygous mutant mice systematically lacking of the phosphatase and tensin homolog (PTEN). Our results identified that the expression of PTEN of the salivary gland tissue diagnosed with Sjogren's syndrome was attenuated in every increasing Grade in tissue classification. Next, we evaluated the effect of salivary gland in heterozygous mutant mice systematically lacking of PTEN. It showed characteristic histology in Sjogren's syndrome. Accordingly, it is carried out mechanism analysis at the protein level for these results.
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