Analysis of PARP as nobel potencial therapeutic targets in oral cancer

• Project/Area Number: 24593036
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TAMATANI Tetsuya 徳島大学, 大学病院, 講師 (30274236)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Youji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (20200214) ; NAGAI Hirokazu 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (50282190) ; UCHIDA Daisuke 獨協医科大学, 医学部, 准教授 (20335798) ; OHE Go 徳島大学, 病院, 助教 (60432762)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 口腔癌 / PARP阻害剤

Outline of Final Research Achievements

One of the main problem for treatment effects of chemoradiotherapy with cancer patients was resistance for chemotherapeutic agent or radiotherapy. Recently, the mechanisms of acquired resistant cancer cells were elucidated to cause the activation of Poly (ADP-ribose) polymerase (PARP). PARP was clarified as molecular targets for breast cancer. The expression and activity of PARP were increased in oral squamous cell cancer (OSCC). We showed that PARP was the molecular targets of chemoresistance and radioresistance. PARP inhibitors inhibited the growth of OSCC. The treatment of PARP inhibitor or chemotherapeutic agent or radiation showed the additive growth inhibition effects. We demonstrated the possibility of new therapy for OSCC patients with PARP inhibition.

Research Products

• [Journal Article] Involvement of miR-518c-5p to Growth and Metastasis in Oral Cancer (2014)
  • Author(s): Makoto Kinouchi, Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai, Youji Miyamoto
  • Journal Title: PLoS One Volume: 9(12)
  • Peer Reviewed / Open Access
• [Journal Article] Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432. (2013)
  • Author(s): Ohe G, Sasai A, Uchida D, Tamatani T, Nagai H, Miyamoto Y
  • Journal Title: Oncol Rep. Volume: Aug;30(2). Issue: 2 Pages: 945-951
  • DOI: 10.3892/or.2013.2480
  • NAID: 120006714457
  • Peer Reviewed
• [Journal Article] The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer. (2013)
  • Author(s): Kuribayashi N, Uchida D, Kinouchi M, Takamaru N, Tamatani T, Nagai H, Miyamoto Y.
  • Journal Title: PLoS One. Volume: Nov 13; 8(11): Issue: 11 Pages: 80773-80778
  • DOI: 10.1371/journal.pone.0080773
  • Peer Reviewed
• [Journal Article] Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor κB activity in human oral cancer cells. (2013)
  • Author(s): Tamatani T, et al
  • Journal Title: Int J Oncol. Volume: 42(3) Pages: 935-944
  • NAID: 120006715982
  • Peer Reviewed
• [Presentation] 口腔癌におけるABCG2とALDH1A1発現の臨床病理学的意義 (2014)
  • Author(s): 玉谷哲也、高丸菜都美、木内 誠、栗林伸行、内田大亮、永井宏和、宮本洋二
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜、神奈川）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Expression of ABCG2, ALDH1A1, CD44, and CD44 variant 9 in human oral squamous cell carcinoma and its relationship with clinical factors. (2014)
  • Author(s): Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai, Youji Miyamoto
  • Organizer: AACR Annual Meeting
  • Place of Presentation: San Diego Convention Center（San Diego, USA）
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] The expression of nuclear factor-kB in human oral squamous cell carcinoma and its relationship with clinical factors (2013)
  • Author(s): Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayasi, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa, Youji Miyamoto
  • Organizer: AACR Annual Meeting 2013
  • Place of Presentation: Washington convention center, USA