Relationship between periodontitis and salivary antioxidant activity by ESR

• Project/Area Number: 24593155
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TAMAKI Naofumi 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (20335615)
• Co-Investigator(Kenkyū-buntansha): ITO Hiro-o 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (40213079) ; YOSHINO Fumihiko 神奈川歯科大学, 歯学研究科(研究院), 准教授 (20308307)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯周病 / 酸化ストレス / 抗酸化力

Outline of Final Research Achievements

The aim of present study was to measure the direct salivary antioxidant activity toward superoxide and hydroxyl radical. Moreover, we clarified the relationship between serum reactive oxygen metabolite (ROM) level and levels of immunoglobulin G antibody to periodontal pathogens. As a result, serum ROM levels were positively correlated with antibody titers to Porphyromonas gingivalis, Prevotella intermedia and Eikenella corrodens.

Research Products

• [Journal Article] Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model (2014)
  • Author(s): Tamaki N, Orihuela R, Inagaki Y, Fukui M, Nagata T, Ito H-O
  • Journal Title: Free Radical Biology and Medicine Volume: 75 Pages: 222-229
  • DOI: 10.1016/j.freeradbiomed.2014.07.034
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Oxidative stress and antibody levels to periodontal bacteria in adults: The Nagasaki Islands study (2014)
  • Author(s): Tamaki N, Hayashida H, Fukui M, Kitamura M, Kawasaki K , Nakazato M, Maeda T, Saito T, Ito H.-O
  • Journal Title: Oral Diseases Volume: 20(3) Issue: 3
  • DOI: 10.1111/odi.12127
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 酸化ストレスと歯周病 (2012)
  • Author(s): 玉木直文，他
  • Journal Title: 四国歯学会 Volume: 25 Pages: 93-99
  • NAID: 120005832476
  • Peer Reviewed
• [Presentation] 歯肉溝浸出液中バイオマーカーと腎機能・糖尿病指標との関連 (2014)
  • Author(s): 玉木直文，水野昭彦，松尾 亮，正木文浩，中川 徹，鈴木雅博，青木良平，松瀬亮一，福井 誠，伊藤博夫
  • Organizer: 第７回日本口腔検査学会総会・学術大会
  • Place of Presentation: 岡山大学50周年記念会館（岡山県岡山市）
  • Year and Date: 2014-09-06 – 2014-09-07
• [Presentation] 水素水摂取による口蓋創傷の治癒促進効果 (2014)
  • Author(s): 玉木直文，Rita Orihuela-Campos，福井 誠，三木かなめ，伊藤博夫
  • Organizer: 第63回口腔衛生学会総会
  • Place of Presentation: 熊本市民会館（熊本県熊本市）
  • Year and Date: 2014-05-29 – 2014-05-31
• [Presentation] Salivary Antioxidant Activity, Cytokines and Periodontitis: The Nagasaki Island Study (2013)
  • Author(s): Tamaki N, Yoshino F, Fukui M, Hayashida H, Yoshida A, Kitamura M, Kawasaki, Nakazato M, Maeda T, Kokeguchi S, Lee MC, Saito T, Ito H-O
  • Organizer: 2nd IADR-APR
  • Place of Presentation: Plaza Athenee (Thailand)
• [Presentation] Stage of hepatocellular carcinoma is associated with periodontitis (2013)
  • Author(s): 玉木 直文
  • Organizer: 第62回日本口腔衛生学会総会
  • Place of Presentation: キッセイ文化ホール （長野県松本市）
  • Invited
• [Presentation] Levels of Serum Markers of Oxidative Stress and Antibodies against Periodontal Pathogens in Community-dwelling Adults with and without Periodontitis: Goto Study (2012)
  • Author(s): Tamaki N, et al.
  • Organizer: First International Conference on Porphyromonas gingivalis and Related Bacterial Species
  • Place of Presentation: Ryojun Hall (長崎県)
• [Presentation] Relationship between plasma reactive oxygen species and progression of periodontitis (2012)
  • Author(s): Tamaki N, et al.
  • Organizer: 10th ICAAPD
  • Place of Presentation: Ulaanbaatar Hotel (Mongol)
• [Presentation] 口腔の健康増進を目指した酸化ストレス制御
  • Author(s): 玉木 直文
  • Organizer: 第44回四国歯学会
  • Place of Presentation: 徳島大学 （徳島県徳島市）
  • Invited
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部予防歯学分野
  • URL: http://preventdent-tokushima-u.jp/index.html
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部予防歯学分野
  • URL: http://preventdent-tokushima-u.jp/result.html
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部予防歯学分野
  • URL: http://preventdent-tokushima-u.jp/result.html