Pathogenicity mechanisms of periodontopathogenic bacteria invaded into cells and retrieval of drugs for removal of invasive bacteria
| Project/Area Number |
24593165
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Meikai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
竹下 玲 明海大学, 歯学部, 准教授 (70236454)
岡本 和彦 明海大学, 歯学部, 准教授 (50271234)
高野 安紀子 明海大学, 歯学部, 講師 (20337504)
|
|---|
| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 歯周病原性細菌 / 炎症性サイトカイン / 歯周疾患 / 細胞内侵入 / サイトカイン発現 / 抗生物質 / 歯周疾患予防 / COX-2 / 口腔上皮細胞 / IL-6 / 細胞内情報伝達 / 抗菌タンパク質 / CAP-18 / beta2-defensin |
|---|
| Outline of Final Research Achievements |
It is widely known that the periodontal pathogenic bacterium Porphyromonas gingivalis (P. gingivalis) has the ability to directly invade to the mucosal epithelial cells. In recent years, several studies indicate that this bacterium invades in the lesion tissue of gingiva in periodontitis patients, indeed. However, it is not completely clarified the pathogenic mechanism of P. gingivalis intracellular invasion. We will investigate any kind of biological activity the invasion of P. gingivalis is able to induce. Moreover, since it is difficult to remove P. gingivalis invaded in the cells in detail by using the general antibiotics, we will also consider any drugs that can remove the intracellularly invaded bacterium or that prevent the intracellular invasion of the pathogen.
|
Report
(6 results)
Research Products
(11 results)
