Regulation of higher brain function via control of tryptophan metabolite kynurenic acid by amino acid intake
| Project/Area Number |
24614010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | The University of Shiga Prefecture |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNUKI Koichiro 近畿大学, 産業理工学部, 准教授 (50378668)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アミノ酸 / 脳神経科学 / 代謝 / 脳環境保護 / 栄養学 / 脳・神経 / 食品 |
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| Outline of Final Research Achievements |
The aim of this study is to prevent and improve higher brain dysfunction by regulation of tryptophan metabolite kynurenic acid production from food scientific and nutritional aspects. In vitro study showed that 10 out of 19 amino acids suppressed kynurenic acid production via inhibition against kynurenic acid precursor kynurenine uptake or kynurenic acid synthesis reaction. In vivo study showed that administration of amino acid related compound suppressed high tryptophan diet-induced kynurenic acid production and lowering dopamine turnover. Behavioral study showed that high tryptophan diet revealed social interaction deficits, and different amino acids composition diet rescued the dysfunction. These results suggest that dietary amino acid can prevent and improve higher brain dysfunction by regulation of tryptophan metabolism in the brain.
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Report
(4 results)
Research Products
(6 results)
