Elucidation of the role of PERK signaling pathway in tumor microenvironment and its application for drug discovery
| Project/Area Number |
24650626
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
TOMIDA Akihiro 公益財団法人がん研究会, がん化学療法センター, ゲノム研究部 部長 (40251483)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | がん微小環境 / UPR / 小胞体ストレス / PERK / グルコース飢餓 / 低酸素 / がん |
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| Outline of Final Research Achievements |
The UPR (unfolded protein response) is a cellular adaptive mechanism that plays an important role in cancer cell survival and proliferation within particular tumor microenvironment. In this study, we focused on two proteins: one is PERK, a central regulatory protein in the UPR, and the other is TBL2, a new function molecule which can interact with PERK during stress. Then, we examined roles of the PERK signaling pathway in cancer cell adaptation to tumor microenvironment by knocking down PERK or TBL2. In addition, aiming at the development of treatment strategy, we searched factors which had a synthetic lethal relationship under conditions inhibiting function of the PERK signaling pathway.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species: AMPK as a Predictive Biomarker for Therapeutic Impact.2013
Author(s)
Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
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Journal Title
Am J Pathol
Volume: 182
Pages: 1800-1810
DOI
Related Report
Peer Reviewed
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[Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of iguanide-induced cytotoxicity during glucose deprivation.2012
Author(s)
Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
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Journal Title
Mol. Cancer Ther.
Volume: 11(5)
Pages: 1082-1091
DOI
Related Report
Peer Reviewed
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