• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Induction of EPR effects on microtumors by combretastatin and its microcirculation mechanism

Research Project

Project/Area Number 24650643
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Clinical oncology
Research InstitutionTohoku University

Principal Investigator

HORI Katsuyoshi  東北大学, 加齢医学研究所, 准教授 (00143032)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords腫瘍血流遮断 / コンブレタスタチン / 腫瘍血管 / EPR効果 / 高分子ミセル / DDS / インターフェイス / 癌
Outline of Final Research Achievements

Nanoparticles are difficult to extravasate from initial stage tumor vessels. Therefore, enhanced-permeability and retention (EPR) effects do not occur in such vessels. A combretastatin derivative, Cderiv, enhances vascular permeability. To elucidate the microcirculation mechanisms of the EPR effect, we investigated the structure and function of tumor vessels and tumor-host interface (T-HI) vessels after Cderiv administration. We also assessed the therapeutic enhancement effects of the combination of doxorubicin micelle with Cderiv. Results show the following. (1) The T-HI vessel endothelium contained many vesiculo-vacuolar organelles (VVO), which contribute to macromolecule extravasation, even after the Cderiv administration. (2) Combination therapy (Cderiv + doxorubicin micelle) markedly inhibited LY80 tumor growth. The presence of VVO and the decline of tumor microcirculation function involving T-HI are important for the EPR effect.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Prevention of cancer recurrence in tumor margins by stopping microcirculation in the tumor and tumor-host interface2014

    • Author(s)
      Hori K, Akita H, Nonaka H, Sumiyoshi A, Taki Y
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 9 Pages: 1196-1204

    • DOI

      10.1111/cas.12477

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Starvation tactics for solid tumors: tumor blood flow interruption via a combretastatin derivative (Cderiv), and its microcirculation mechanism.2012

    • Author(s)
      Hori K
    • Journal Title

      Cancer Metastasis Rev

      Volume: 31 Issue: 1-2 Pages: 109-122

    • DOI

      10.1007/s10555-011-9333-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi