Construction of cooperating peptide probes for tumor detection

Research Project

Project/Area Number	24650649
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Clinical oncology
Research Institution	Japanese Foundation for Cancer Research
Principal Investigator	MATSUMURA Sachiko 公益財団法人がん研究会, がん研究所, 特任研究員 (90414052)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	がん / ペプチド / リガンド / ナノバイオ / 癌 / 蛍光イメージング / 分子認識
Outline of Final Research Achievements	The aim of this work is to construct peptide probes that use a cooperative interaction of molecules containing ligands on cells. Peptides with a ligand sequence were assembled to form a nano-sized structure. The assemblage containing many ligand peptides specifically bound to tumor cells that expressed the target proteins.