Protective effects of hydrogen against irradiation
| Project/Area Number |
24651055
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OHTA Shigeo 日本医科大学, 医学(系)研究科(研究院), 教授 (00125832)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIMURA Naomi 日本医科大学, 老人病研究所生化学部門, 准教授 (60283800)
WOLF Alexander 日本医科大学, 老人病研究所生化学部門, 講師 (20434136)
NISHIMAKI Kiyomi 日本医科大学, 老人病研究所生化学部門, マネジメントスタッフ (00465345)
ICHIMIYA Harumi 日本医科大学, 老人病研究所生化学部門, アシスタントサポートスタッフ (40553251)
YOKOTA Takashi 日本医科大学, 老人病研究所分子生物学部門, マネジメントスタッフ (30445829)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 損傷 / 水素分子 / 抗酸化物質 |
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| Research Abstract |
Ionizing irradiation produces free radicals such as hydroxyl radical (•OH) by reacting with water. Then, these free radicals act as a trigger for initiating the free radical chain reaction, resulting in the generation of lipid peroxides, which cause the damages in cells. The author has shown that molecular hydrogen (H2) reacts with •OH to protect cells. Moreover, H2 protects cells, organs and mice against irradiation. This study revealed that a low concentration (~0.08 mM) of molecular hydrogen (H2) terminates the free radical chain reaction to prevent lipid peroxides and to protect cells. The author would like to direct that this study is valuable as a basic investigation, but insufficient for the actual application in public.
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Report
(3 results)
Research Products
(90 results)
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[Journal Article] H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia2012
Author(s)
Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S
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Journal Title
J. Am. Heart Assoc
Volume: 1(5)
Issue: 5
DOI
Related Report
Peer Reviewed
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[Journal Article] Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain.2011
Author(s)
Shinmura K, Tamaki K, Sano M, Nakashima-Kamimura N, Alexander MW, Amo T, Ota S, Katsumata Y, Fukuda K, Ishiwata K, Suematsu M, Adachi T.
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Journal Title
Circ Res
Volume: 109(4)
Issue: 4
Pages: 396-406
DOI
Related Report
Peer Reviewed
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[Presentation] APP transgenic mice with oxidative stress.2013
Author(s)
Kamimura N, Kanamaru T, Yokota T, Iuchi K, Nishimaki K, Takami S, Akashiba H, Shitaka Y, Katsura K-I, Katayama Y, Ohta S.
Organizer
The 11th International Conference AD/PD 2013
Place of Presentation
Italy
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