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Making the concave soft micro particles with the same shape as red blood cell

Research Project

Project/Area Number 24656466
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionUniversity of Toyama

Principal Investigator

YAMAMOTO tatsumi  富山大学, 大学院理工学研究部(工学), 助教 (60220480)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Makoto  富山大学, 大学院理工学研究部(工学), 教授 (90301803)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords人工赤血球 / コーヒーステイン現象 / アルギン酸ゲル微粒子 / 微粒子形成操作 / スクリーン印刷 / コーヒー現象
Outline of Final Research Achievements

Although the technique to make uniform fine particles of the red blood cell size (7-8μm in diameter) was rare, we made it possible by drying the droplets of sodium alginate aqueous solution injected in the air by the ink-jet method. However, the particles produced by this technique are spherical, and different from the concave shape of the red blood cells. The red blood cells could pass the blood capillary having the inner diameter of a few μm by the concave shape. As the next step, we tried the production method of artificial soft particles which had the shape and size as red blood cell, and had the prospect by using the coffee-stain phenomenon when the aqueous alginate droplets ejected from the fine nozzle landed on water-shedding plate.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2015 2012 Other

All Presentation (4 results)

  • [Presentation] 赤血球形状のゲル微粒子作製についての基礎的検討2015

    • Author(s)
      山本辰美,若槻峻,早苗秀敏,中村真人
    • Organizer
      化学工学会第80年会
    • Place of Presentation
      芝浦工業大学豊洲キャンパス
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Production of hemoglobin-containing micro-gel beads as oxygen carriers for cell culture2012

    • Author(s)
      T. Takeda, S. Iwanaga, N. Saitou and M. Nakamura,
    • Organizer
      3rd TERMIS World Congress 2012
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Research-status Report
  • [Presentation] ヘモグロビン含有アルギン酸ゲルビーズの作成:培養用酸素運搬体としての評価

    • Author(s)
      竹田朋恵、岩永進太郎、斉藤典彰、中村真人
    • Organizer
      第1回日本バイオマテリアル学会 北陸若手研究発表会
    • Place of Presentation
      石川
    • Related Report
      2012 Research-status Report
  • [Presentation] インクジェットプリンタを用いた均一径微粒子の作製と二重DDSへの応用に向けた基礎検討

    • Author(s)
      岩永進太郎、齊藤典彰、早苗秀敏、中村真人
    • Organizer
      化学工学会78年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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