How does a baculovirus manipulate behavior of the host insect?
| Project/Area Number |
24658047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied entomology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATSUMA Susumu 東京大学, 農学生命科学研究科, 准教授 (20378863)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | バキュロウイルス / 行動 / カイコ / ptp / 行動異常 / RNA-seq |
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| Research Abstract |
By screening Bombyx mori nucleopolyhedrovirus mutants, we identified a gene, arif-1, that is required for virus-induced abnormal behavior. The arif-1 mutants did not show any phenotypic abnormalities in cultured cells, but exhibited a strikingly low virus growth in B. mori larvae.
We also performed RNA-seq experiments using brain mRNA from healthy and virus-infected silkworms and identified more than 10 host genes of which expression was altered by virus infection. Functional analyses of these host genes are now in progress.
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Report
(3 results)
Research Products
(22 results)
