Construction of screening system and screening of novel tight junction inhibitors
| Project/Area Number |
24658107
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
USUI Takeo 筑波大学, 生命環境系, 准教授 (60281648)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | タイトジャンクション / 化合物探索 / 可逆的TJ開口 / Claudin-1 / Claudin-4 / L細胞 / MDCK細胞 / Ca2+流入 |
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| Research Abstract |
Tight Junction is a sealing structure in the closely associated area of two adjacent cells located in epithelium of skin, intestine and so on. TJ functions not only a impermeable barrier to bacteria and exogeneous toxins, but also to medical drug, especially biomedicines. Therefore, it is required for injection or the other invasive methods to give medication the biomedicines to patients. However, if we have a compound which open the TJ transiently, it would be possible to give the orally or percutaneous medication.
Therefore, we constructed the two screening systems, and screened the compounds which open the TJ transiently. We successfully obtained one compound.
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Report
(3 results)
Research Products
(7 results)
