| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
An experimental system screening flavonoids that enhance the differentiation of mouse B cells to regulatory B cells or those activating regulatory B cells was established. Using this system, we found that kaempferol and tamarixetin upregulated interleukin-10 -producing regulatory B cells in the presence of lipopolisaccharides. Oral administration of kaempferol was found to increase the ratio of regulatory B cells in spleens and mesenteric lymph nodes of mice. Kaempferol and tamarixetin showed an antagonistic activity to aryl-hydrocarbon receptor, and the activity was suggested to contribute to the up-regulation of regulatory B cells. This study demonstrates a novel approach to develop anti-allergic and anti-inflammatory functional foods targeting regulatory B cells.
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