Development of Molecular Machine System Switched by Redox Stimulation
| Project/Area Number |
24659003
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
KIYOSEI Takasu 京都大学, 薬学研究科(研究院), 教授 (10302168)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子マシン / コンホメーション / 可逆性 / キノン / ヒドロキノン / 酸化還元 / 構造変化 / アミド結合 / 水素結合 / 分子スイッチ / アミド |
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| Research Abstract |
Quinones and hydroquinones are ubiquitous components and play key roles of electron transport chain in living cells. We planned to develop a new molecular machine, whose conformation is switchable by the stimulation of redox potential, based on the difference of hydrogen-bonding network between quinones (hydrogen-bond acceptor) and hydroquinones (hydrogen-bond donor).
We designed and synthesized several quinones/hydroquinones possessing an amide side chain at 2-position. it was made clear that conversion of quinones and hydroquinones is reversible under the redox conditions. Moreover, it was proved that the conformation of each compound is very different by spectral analysis such as X-ray, NMR and IR. The preparation of molecular assembler and/or polymer is under investigation.
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Report
(3 results)
Research Products
(8 results)
