| Project/Area Number |
24659006
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OCHIAI Masahito 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50127065)
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| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 有機化学 / CHアミノ化反応 / ナイトレノイド / 臭素 / 超原子価 / アルカン |
|---|
| Research Abstract |
Our project involves a development of new research field “chemistry of hypervalent bromane”. We have developed a new methodology for direct regioselective alkane C-H amination, which involves in situ generation of iminobromane. Iminobromane generated from diacyloxybromane by the reaction with triflylamide in alkane as a solvent undergoes alkane C-H amination. Excellent regioselectivity as well as stereoselectivity were observed in the reaction.
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