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Evaluation of Kaki Calyx as natural resources

Research Project

Project/Area Number 24659056
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Environmental pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

ISHII YASUKO  静岡県立大学, 薬学部, 講師 (00106436)

Co-Investigator(Kenkyū-buntansha) UMEHARA Kaoru  静岡県立大学, 薬学部, 講師 (40185070)
Research Collaborator NOGE Ichiro  沼津市立病院, 薬剤部, 部長
KATO Yuki  沼津市立病院, 薬剤部, 薬剤師
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords柿蔕 / 吃逆 / がん患者 / 神経伝達物質 / 臨床効果 / 生理活性 / 柿 / しゃっくり / 天然資源 / 薬用資源学
Outline of Final Research Achievements

Effects on neurotransmitter of Shitei (Kaki Calyx), a hiccups remedy, were examined in rat. The levels in rat cerebrospinal fluid of not GABA but aspartic acid, glycine, DOPAC and HVA, dopamine metabolites, changed after oral administration of shitei-decoction. Basing these results, we are going to screen effective components in calyx of kaki native to Japan. On the other hand, as clinical approach to clarifying the action mechanism of shitei, the clinical efficacy of shitei-decoction was retrospectively evaluated in some hospital adopting the different recipe, and it was suggested that high-concentration shitei-decoction was appropriate for treatment of hiccups developed after chemotherapy. Therefore, we will plan to confirm it by a prospective study.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2015

All Presentation (2 results)

  • [Presentation] 日本人閉経後乳がん患者におけるアロマターゼ阻害薬のPKとPDに関する研究2015

    • Author(s)
      古谷翔太、石井康子、鈴木祐介、木村正幸、加藤有希、野毛一郎、林秀樹、伊藤邦彦、賀川義之
    • Organizer
      日本薬学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本人閉経後乳がん患者のアロマターゼ阻害薬による副作用と エストロゲン濃度に関する研究2015

    • Author(s)
      鈴木祐介、石井康子、古谷翔太、加藤有希、野毛一郎、木村正幸、賀川義之
    • Organizer
      日本薬学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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