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Neural stem cell transplantation for refractory idiopathic or diabetic gastroparesis

Research Project

Project/Area Number 24659103
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionKeio University

Principal Investigator

SUZUKI Hidekazu  慶應義塾大学, 医学部, 准教授 (70255454)

Co-Investigator(Kenkyū-buntansha) URAOKA Toshio  慶應義塾大学, 医学部, 講師 (80448216)
KAWASE Satoshi  慶應義塾大学, 医学部, 特任助教 (80468496)
YAHAGI Naohisa  慶應義塾大学, 医学部, 教授 (90292937)
Research Collaborator FUKUHARA Seiichiro  慶應義塾大学, 医学部, 大学院生
MASAOKA Tastuhiro  慶應義塾大学, 医学部, 助教
UCHIDA Masayuki  明治乳業研究所, 食機能科学研究所, リーダー
NISHIMURA Soraya  慶應義塾大学, 医学部, 大学院生
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胃不全麻痺 / 糖尿病 / 脂質異常症 / アポプロテインE / 胃排出 / 神経幹細胞 / 神経幹細胞移植 / neurosphere / 13C酢酸呼気試験 / 神経堤 / 移殖 / 呼気試験
Research Abstract

Delayed gastric emptying was observed in 27 % of db/db mouse with a significant decrease in the serum ApoE level and in the myenteric nNOS and GFAP expression. The gastric emptying was also significantly delayed in ApoE knockout (KO) mouse with a decrease in the expression of nNOS and GFAP in myenteric plexus. Transplantation of neural stem cells (NSCs) improved delayed gastric emptying in nNOS KO mice and ApoE KO mise. The expressions of nNOS and GFAP in myenteric plexus were restored by transplantation of NSCs. Transplantation of NSCs restored the delayed gastric emptying in apoE knockout mice, suggesting a promising application of regenerative therapy against gastroparesis and a possible development of serum ApoE as a potential biomarker for gastrointestinal motility disorders.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (126 results)

All 2014 2013 2012 2011 Other

All Journal Article (54 results) (of which Peer Reviewed: 51 results,  Open Access: 6 results) Presentation (64 results) (of which Invited: 9 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Randomised clinical trial : rikkunshito in the treatment of functional dyspepsia–a multi-centre, double-blind, randomised, placebo-controlled study2014

    • Author(s)
      Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takabayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
    • Journal Title

      Neurogastr oenterol. Motil.

      Volume: (Epub) Issue: 7 Pages: 950-961

    • DOI

      10.1111/nmo.12348

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy.2014

    • Author(s)
      Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
    • Journal Title

      Neurogastroenterol. Motil.

      Volume: - Issue: 6 Pages: 764-771

    • DOI

      10.1111/nmo.12319

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ヘリコバクター・ピロリ感染胃炎と機能性ディスペプシア2014

    • Author(s)
      鈴木秀和
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 15(2) Pages: 56-61

    • Related Report
      2013 Final Research Report
  • [Journal Article] New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib.2014

    • Author(s)
      Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, SY., Suzuki, H., Tsuchimoto, K.
    • Journal Title

      Curr. Pharm. Des.

      Volume: 20(7) Pages: 1097-1103

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does bile reflux influence the progression of Barrett's esophagus to adenocarcinoma?2014

    • Author(s)
      Masaoka, T., Suzuki, H.
    • Journal Title

      J. Neurogastroenterol. Motil.

      Volume: 20(1) Issue: 1 Pages: 124-126

    • DOI

      10.5056/jnm.2014.20.1.124

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A questionnaire-based survey on the diagnosis and management of inflammatory bowel disease in East Asian countries in 2012.2014

    • Author(s)
      Hida, N., Nakamura, S., Hahm, K-B., Sollano, J.D., Zhu, Q., Rani, A.A., Syam, A.F., Kachintorn, U., Ueno, F., Joh, T., Naito, Y., Suzuki, H., Takahashi, S., Fukudo, S., Fujiwara, Y., Kinoshita, Y., Uchiyama, K., Yamaguchi, Y., Yoshida, A., Arakawa, T., Matsumoto, T., The IGICS Study Group.
    • Journal Title

      Digestion

      Volume: 89(1) Issue: 1 Pages: 88-103

    • DOI

      10.1159/000356706

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Superiority of pulmonary administration of mepenzolate bromide over of her routes as treatment for chronic obstructive pulmonary disease2014

    • Author(s)
      Tanaka K., et al.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep04510

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNAs in Barrett’s esophagus: Future prospects.2014

    • Author(s)
      Matsuzaki, J., Suzuki, H.
    • Journal Title

      Front. Genet.

      Volume: 5 Pages: 69-69

    • DOI

      10.3389/fgene.2014.00069

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study) : a multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial2013

    • Author(s)
      Suzuki, H., Kusunoki, H., Kamiya, T., Futagami, S., Yamaguchi, Y., Nishizawa, T., Iwasaki, E., Matsuzaki, J., Takahashi, S., Sakamoto, C., Haruma, K., Joh, T., Asakura, K., Hibi, T.
    • Journal Title

      ueg journal

      Volume: 1(6) Issue: 6 Pages: 445-452

    • DOI

      10.1177/2050640613510904

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.2013

    • Author(s)
      Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O, Asakura K, Saya H, Hibi T
    • Journal Title

      Br J Cancer

      Volume: 109 Issue: 2 Pages: 379-386

    • DOI

      10.1038/bjc.2013.314

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan2013

    • Author(s)
      Suzuki H, Matsuzaki J, Okada S, et al.
    • Journal Title

      United European Gastroenterology Journal

      Volume: (印刷中) Issue: 3 Pages: 175-183

    • DOI

      10.1177/2050640613485238

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired heme oxygenase-1 induction in the gastric antrum induces disruption of the interstitial cells of Cajal network in a rat model of streptozotocin-induced diabetes.2013

    • Author(s)
      Sachiko Mogami
    • Journal Title

      Neurogastroenterol. Motil.

      Volume: in press Issue: 7 Pages: 609-609

    • DOI

      10.1111/nmo.12122

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pyloriinfection in functional dyspepsia.2013

    • Author(s)
      Suzuki, H., Moayyedi, P.
    • Journal Title

      Nat. Rev. Gastroenterol. Hepatol.

      Volume: 10(3) Issue: 3 Pages: 168-74

    • DOI

      10.1038/nrgastro.2013.9

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori CagAを分解するROS誘導性オートファジーはCD44v9発現がん幹細胞で抑制されCagAが蓄積する2013

    • Author(s)
      津川仁,鈴木秀和
    • Journal Title

      細胞工学

      Volume: 32(3) Pages: 324-325

    • Related Report
      2013 Final Research Report
  • [Journal Article] 機能性ディスペプシア2013

    • Author(s)
      鈴木秀和,西澤俊宏,日比紀文
    • Journal Title

      日本内科学会雑誌

      Volume: 102(1) Pages: 63-69

    • NAID

      10031170564

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effect of ursodeoxycholic acid and endoscopic sphincterotomy in long-term stenting for common bile duct stones.2013

    • Author(s)
      Toshihiro Nishizawa
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 28 Issue: 1 Pages: 63-7

    • DOI

      10.1111/jgh.12012

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of reflux symptom related quality of life after <i>Helicobacter pylori</i> eradication therapy2013

    • Author(s)
      Kenro Hirata
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 2 Pages: 172-178

    • DOI

      10.3164/jcbn.12-107

    • NAID

      130004466704

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain- containing m-Numb protein expression in regenerating gastric mucosa.2013

    • Author(s)
      Tetsufumi Takahashi
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: 1-13

    • DOI

      10.1371/journal.pone.0053540

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier.2013

    • Author(s)
      Mizuno, S., Yamagishi, Y., Ebinuma, H., Nakamoto, N., Katahira, M., Sasaki, A., Sakamoto, M., Suzuki, H., Kanai, T., Hibi, T.
    • Journal Title

      Clin. J. Gastroenterol.

      Volume: 6(2) Pages: 188-192

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of microRNAin gastric malignancy.2013

    • Author(s)
      Nishizawa, T., Suzuki, H
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 14(5) Issue: 5 Pages: 9487-9496

    • DOI

      10.3390/ijms14059487

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delay of second-line eradication therapy for H. pylori can increase eradication failure.2013

    • Author(s)
      Nishizawa, T., Suzuki, H., Takahashi, M., Suzuki, M., Hibi, T.
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 28(10) Issue: 10 Pages: 1608-1610

    • DOI

      10.1111/jgh.12281

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends of second-line eradication therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area.2013

    • Author(s)
      Asaoka, D., Nagahara, A., Matsuhisa, T., Takahashi, S., Tokunaga, K., Kawai, T., Suzuki, H., Suzuki, M., Nishizawa, T., Kurihara, N., Ito, M., Sasaki, H., Omata, F., Mizuno, S., Torii, A., Ohkusa, T., Mine, T., Sakaki, N.
    • Journal Title

      Helicobacter

      Volume: 18(6) Issue: 6 Pages: 468-472

    • DOI

      10.1111/hel.12063

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Do we need to eradicate H. pylori in patients with GORD?2013

    • Author(s)
      Masaoka, T., Suzuki, H.
    • Journal Title

      ueg journal

      Volume: 1(4) Issue: 4 Pages: 223-225

    • DOI

      10.1177/2050640613497713

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis2013

    • Author(s)
      J. Matsuzaki, H. Suzuki, H. Tsugawa, M. Watanabe, S. Hossain, T. Akaike, T. Hibi, et. al.
    • Journal Title

      Gastroenterology

      Volume: (In Press) Issue: 6 Pages: 1300-1311

    • DOI

      10.1053/j.gastro.2013.08.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.2013

    • Author(s)
      Tanaka K., et al.
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 1-13

    • DOI

      10.1038/ncomms3686

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic microvascular patterns of gastrointestinal cancer.2013

    • Author(s)
      Nishizawa, T., Suzuki, H.
    • Journal Title

      Microvasc. Rev. Commun.

      Volume: 6(1) Pages: 9-12

    • NAID

      130004467816

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors.2013

    • Author(s)
      Manabu Nakashita
    • Journal Title

      Dig. Dis. Sci.

      Volume: 58 Pages: 354-62

    • DOI

      10.1007/s10620-012-2350-x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The tumor suppressor microRNA -29c is downregulated and restored by celecoxib in human gastric cancer cells2013

    • Author(s)
      Saito Y, Suzuki H, Imaeda H, Matsuzaki J, et al.
    • Journal Title

      International Journal of Cancer

      Volume: 132 Issue: 8 Pages: 1751-1760

    • DOI

      10.1002/ijc.27862

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Minimally invasive surgery for esophageal epiphrenic diverticulum – the results of our experience and 133 patients in 25 published series.2013

    • Author(s)
      Yuki Hirano
    • Journal Title

      Surgery Today

      Volume: 43 Issue: 1 Pages: 1-7

    • DOI

      10.1007/s00595-012-0386-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CDX1 directs gastric intestinal metaplasia via induction of stemness-associated reprogramming factors SALL4 and KLF52012

    • Author(s)
      Fujii, Y.
    • Journal Title

      Proc. Natl. Acad. Sci.USA

      Volume: 109 Issue: 50 Pages: 20584-20589

    • DOI

      10.1073/pnas.1208651109

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells2012

    • Author(s)
      Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano 0, Matsuzaki J, et al.
    • Journal Title

      Cell Host & Microbe

      Volume: 12 Issue: 6 Pages: 764-777

    • DOI

      10.1016/j.chom.2012.10.014

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High frequency of overlap between functional dyspepsia and overactive bladder2012

    • Author(s)
      Matsuzaki J, Suzuki H, Fukushima Y, et al.
    • Journal Title

      Neurogastroenterology and Motility

      Volume: 24 Issue: 9 Pages: 821-827

    • DOI

      10.1111/j.1365-2982.2012.01939.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea : Open-label Prospective Pilot Trial.2012

    • Author(s)
      Fukushima Y, Suzuki H, Matsuzaki J, et al.
    • Journal Title

      Journal of Neurogastroenterology and Motility

      Volume: 18 Issue: 3 Pages: 317-323

    • DOI

      10.5056/jnm.2012.18.3.317

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity2012

    • Author(s)
      Asano, T., Suzuki, H., et al
    • Journal Title

      Biochem.Biophys.Res.Com.

      Volume: 420(2) Issue: 2 Pages: 444-449

    • DOI

      10.1016/j.bbrc.2012.03.015

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Classification of functional dyspepsia based on concomitant bowel symptoms2012

    • Author(s)
      Matsuzaki J, Suzuki H, Asakura K, et al
    • Journal Title

      Neurogastroenterol Motil

      Volume: 24 Issue: 4 Pages: 1643-1645

    • DOI

      10.1111/j.1365-2982.2011.01859.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced ghrelin production induced anorexia after rat gastric ischemia and reperfusion2012

    • Author(s)
      Mogami S, Suzuki H, Fukuhara S, Matsuzaki J, et al
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 302 Issue: 3 Pages: G359-G364

    • DOI

      10.1152/ajpgi.00297.2011

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction.2012

    • Author(s)
      Iwasaki E
    • Journal Title

      Dig Dis Sci

      Volume: 57 Issue: 4 Pages: 858-864

    • DOI

      10.1007/s10620-011-1953-y

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biliary Findings Assist in Predicting Enlargement of Intraductal Papillary Mucinous Neoplasms of the Pancreas2012

    • Author(s)
      Matsuzaki J, Suzuki H, Okuda S, et al.
    • Journal Title

      Clininal Gastroenterology and Hepatology

      Volume: (印刷中) Issue: 5 Pages: 548-554

    • DOI

      10.1016/j.cgh.2012.11.027

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line <i>Helicobacter pylori</i> eradication therapy2012

    • Author(s)
      Toshihiro Nishizawa
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 51 Issue: 2 Pages: 114-116

    • DOI

      10.3164/jcbn.D-11-00029R1

    • NAID

      130004879303

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies.2012

    • Author(s)
      Juntaro Matsuzaki
    • Journal Title

      Antimicrob. Agent Chemother.

      Volume: 56 Issue: 3 Pages: 1643-45

    • DOI

      10.1128/aac.05941-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Capsule endoscopy assists in the complete deworming of parasites.2012

    • Author(s)
      Shinsuke Kobayashi
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 27 Issue: 7 Pages: 1253-1253

    • DOI

      10.1111/j.1440-1746.2012.07154.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] FecA1, a bacterial iron transporter, determines the survival of Helicobacter pylori in the stomach2012

    • Author(s)
      Tsugawa H, Suzuki H, Matsuzaki J, et al
    • Journal Title

      Free Radic Biol Med

      Volume: 52 Issue: 6 Pages: 1003-1010

    • DOI

      10.1016/j.freeradbiomed.2011.12.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dual therapy for third-line H. pylori eradication and urea breath test prediction.2012

    • Author(s)
      Toshihiro Nishizawa
    • Journal Title

      World J. Gastroenterol.

      Volume: 18 Issue: 21 Pages: 2735-2738

    • DOI

      10.3748/wjg.v18.i21.2735

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transmural pressure loading enhances gastric mucosal proliferation.2012

    • Author(s)
      Hiromasa Nakamizo
    • Journal Title

      Dig. Dis. Sci.

      Volume: 57 Pages: 2545-2554

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Questionnaire-Based Survey on Screening for gastric and colorectal cancer by physicians in East Asian countries in 2010.2012

    • Author(s)
      Yuji Naito
    • Journal Title

      Digestion

      Volume: 86 Issue: 2 Pages: 94-106

    • DOI

      10.1159/000339342

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Questionnaire-based survey conducted in 2011 concerning endoscopic management of Barrett’s esophagus in East Asian countries.2012

    • Author(s)
      Norihisa Ishimura
    • Journal Title

      Digestion

      Volume: 86 Issue: 2 Pages: 136-146

    • DOI

      10.1159/000339778

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-density lipoprotein receptorrelated protein-1 (LRP-1) mediates autophagy and apoptosis caused by Helicobacter pyloriVacA2012

    • Author(s)
      Yahiro, K., Suzuki, H., et al.
    • Journal Title

      J. Biol. Chem

      Volume: 287(37) Issue: 37 Pages: 31104-15

    • DOI

      10.1074/jbc.m112.387498

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a novel microRNA promoter microarray for ChIP-on chip assay to identify epigenetically regulated microRNAs2012

    • Author(s)
      Saito Y, Suzuki H, Taya T, Nishizawa M, Tsugawa H, Matsuzaki J, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 426 Issue: 1 Pages: 33-37

    • DOI

      10.1016/j.bbrc.2012.08.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Are solifenacin and ramosetron really ideal to treat irritable bowel syndrome?: Author’s Reply.2012

    • Author(s)
      Hidekazu Suzuki
    • Journal Title

      J. Neurogastroenterol. Motil.

      Volume: 18 Issue: 4 Pages: 459-459

    • DOI

      10.5056/jnm.2012.18.4.459

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication2012

    • Author(s)
      Saito y, Suzuki H, Tsugawa H, Imaeda H, Matsuzaki J, et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e47396-e47396

    • DOI

      10.1371/journal.pone.0047396

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity.2012

    • Author(s)
      Suemasu S., et al.
    • Journal Title

      Biochem Pharmacol.

      Volume: 84 Issue: 11 Pages: 1470-1481

    • DOI

      10.1016/j.bcp.2012.09.016

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan.2012

    • Author(s)
      Hidekazu Suzuki
    • Journal Title

      Keio J. Med.

      Volume: 61 Pages: 109-119

    • NAID

      10031140763

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced gastric ghrelin induced c-kit protein expression in rats with gastric outlet obstruction.2012

    • Author(s)
      Eisuke Iwasaki
    • Journal Title

      Dig. Dis. Sci.

      Volume: 57 Issue: 12 Pages: 3308-3309

    • DOI

      10.1007/s10620-012-2451-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of oxidative stress in stomach disorders2011

    • Author(s)
      Suzuki, H., et al.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 50 Issue: 1 Pages: 35-39

    • DOI

      10.3164/jcbn.11-115SR

    • NAID

      130004466668

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 脂質代謝に関与するアポリポプロテインEの動態変化に伴う胃運動及び胃壁内神経叢への影響2014

    • Author(s)
      福原誠一郎、正岡建洋、鈴木秀和
    • Organizer
      シンポジウム8「生活習慣病と消化器疾患・病態生理学の新たな展開.第100回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Impairment of apolipoprotein E evokes delayed gastric emptying through nitrergic dysfunction2014

    • Author(s)
      Fukuhara, S., Suzuki, H., Masaoka, T., Tsugawa, H., Okada, S., Mori, H., Hirata, K., Matsuzaki, J., Iwasaki, E., Mizushima, T., Suzuki, M.
    • Organizer
      The 7th Inter national Gastrointestinal Consensus Symposium (IGICS)"Gastrointestinal Function and Diseases", The 10^<th> J GA
    • Place of Presentation
      Fukushima, Japan
    • Year and Date
      2014-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of stemness factors in the intestinal transdifferentiation of gastric epithelial cells2013

    • Author(s)
      Fujii, Y., Suzuki, H., Aburatani, H., Hatakayama, M.
    • Organizer
      "The latest advances in gastr ic cancer research, from basic science to therapeutics", The 4^<th> J CA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu, Japan
    • Year and Date
      2013-12-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Escaped autophagy of H. pylori-derived oncoprotein CagA in gastric cancer stem-like cells2013

    • Author(s)
      Suzuki, H.
    • Organizer
      Session 5"Cancer stem cells (2)""The latest advances in gastr ic cancer research, from basic science to therapeutics", The 4^<th> J CA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu, Japan
    • Year and Date
      2013-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 実験動物を用いたグレリン動態と胃排出障害2013

    • Author(s)
      岩崎栄典、鈴木秀和、最上祥子、正岡建洋、金井隆典、塚田信廣
    • Organizer
      シンポジウム10「brain-gutペプチドの病態生理学」第50回記念日本臨床生理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] The dynamics of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori infection2013

    • Author(s)
      Fukuhara, S., Masaoka, T., Suzuki, H., Matsuzaki, J., Saito,Y., Tsugawa, H., Hirata, K., Okada, S., Mori, H., Yasui, M., Hibi, T.
    • Organizer
      The 15^<th> Taishotoyama Inter national Symposium on Gastroenterology
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Symposium (Steps towar ds gastr ic cancer ) Lecture"Role of microRNA and cancer stem cells in gastric carcinogenesis"2013

    • Author(s)
      Suzuki, H.
    • Organizer
      The XXVI^<th> Inter national Workshop on Helicobacter and related bacter ia in chronic digestive inflammation and gastr ic cancer
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Application of ^<13>C-acetic acid breath test for animals with impaired gastric motility2013

    • Author(s)
      Fukuhara, S., Suzuki, H., Masaoka, T., Suemasu, S., Matsuzaki, J., Tsugawa, H., Okada, S., Hirata, K., Mori, H., Saito, Y., Mizushima, T., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2013-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] The Loss of Work Productivity Associated with Gastroesophageal Reflux Disease(GERD) in a Japanese Working Population2013

    • Author(s)
      Suzuki, H., Matsuzaki, J., Masaoka, T., Okada, S., Inadomi, J., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2013-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Trough Anti-Oxidative Stress Mechanism2013

    • Author(s)
      Okada, S., Suzuki, H., Masaoka, T., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Saya, H., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Florida, U.S.A.
    • Year and Date
      2013-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 消化管機能異常モデルにおけるグレリンと胃運動との関係2013

    • Author(s)
      最上祥子、鈴木秀和、福原誠一郎、正岡建洋、松崎潤太郎、津川仁、日比紀文
    • Organizer
      ワークショップ5「消化管ホルモン研究の基礎と臨床」第9回日本消化管学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-01-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Bile Acids Enhance Oncogenic miR-221/222 in the Transformation From Barrett’s Esphagus to Adenocarcinoma.2013

    • Author(s)
      Matsuzaki, J., Suzuki, H., Tsugawa, H., Saito, Y., Hossain, S., Arai, E., Sekine, S., Kanai, Y., Watanabe, M., Akaike, T., Mukaisho, K., Auwerx, J., Hibi, Y.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Role of Helicobacter pylori infection in the disease entity of functional dyspepsia2012

    • Author(s)
      Suzuki, H.
    • Organizer
      Symposium 7"Current Issues on Functional Dyspepsia". Seoul Inter national Digestive Disease Symposium 2012 (SIDDS2012)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Eradication of Helicobacter pylori with 10-day sitafloxacin-based triple therapy as a third- or fourth-line rescue therapy : preliminary results of open-label randomized trial2012

    • Author(s)
      Mori, H., Suzuki, H., Matsuzaki, J.,Tsugawa, H., Fukuhara, S., Okada, S., Hirata, K., Hibi, T.
    • Organizer
      The Amer ican College of Gastroenterology Annual Scientific Meeting (ACG2012)
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2012-10-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Improvement in the quality of life related to reflux symptoms after Helicobacter pylori eradication therapy2012

    • Author(s)
      Hirata, K., Suzuki, H., Matsuzaki, J., Masaoka, T., Saito, Y., Nishizawa, T., Iwasaki, E., Fukuhara, S., Okada, S., Hibi, T.
    • Organizer
      2012 J oint Inter national Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2012-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] The GerdQ is a useful tool for evaluating the patients'satisfaction and identifying the patients with"unmet medical needs"2012

    • Author(s)
      Okada, S., Suzuki, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Hibi, T.
    • Organizer
      2012 J oint Inter national Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2012-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] High frequency of overlap between functional dyspepsia, irritable bowel syndrome and overactive bladder2012

    • Author(s)
      Suzuki, H., Matsuzaki, J., Fukushima, Y., Hirata, K., Fukuhara, S., Okada, S., Hibi, T.
    • Organizer
      2012 J oint Inter national Neurogastroenterology and Motility Meeting
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Impaired heme oxygenase-1 upregulation induced decreased interstitial cells of Cajal in streptozotocin-induced diabetes model2012

    • Author(s)
      Mogami, S., Suzuki, H., Tsugawa, H., Matsuzaki, J., Hibi, T.
    • Organizer
      The 14^<th> Meeting of International Conference on Ulcer Research (ICUR)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of CD44 variant expression as a recurrence marker of gastric cancer after endoscopic submucosal dissection2012

    • Author(s)
      Hirata, K., Suzuki, H., Saya, H., Imaeda, H., Nagano, O., Tsugawa, H., Matsuzaki, J., Okada, S., Fukuhara, S., Mukai, M., Hibi, T.
    • Organizer
      The 10^<th> annual meeting of the Inter national Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2012-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori -infected mice2012

    • Author(s)
      Saito, Y., Suzuki, H., Tsugawa, H., Suzuki, S., Matsuzaki, J., Hirata. K., Saito, H,, Hibi, T.
    • Organizer
      The 2nd Asian Pacific Topic Conference, Asian Pacific Helicobacter pylori Meeting 2012
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2012-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] GERDQ is superior tool for the evaluation of GERD symptoms and unmet medical needs to the Carlsson-Dent questionnaire – a large scale survey –2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] GERDQ is an easy and useful tool for assessing the severity of gastroesophageal reflux disease and identifying patients with “unmet medical needs”.2012

    • Author(s)
      Sawako Okada
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Dynamics of aquaporin-4 in gastric parietal cells in the hyperplastic gastric fundic mucosa of histamine type 2 receptor knockout mice.2012

    • Author(s)
      Seiichiro Fukuhara
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Specific amino acid mutation of p53 enhanced the stability of intracellular cagA by inhibiting autophagy induction.2012

    • Author(s)
      Hitoshi Tsugawa
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] MicroRNA-21 expression causes nuclear loss of the tumor suppressor PDCD4 in precancerous gastric adenomas.2012

    • Author(s)
      Kenro Hirata
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] The extension of mucosal lesions, Helicobacter pylori infection status and API2-MALT1 positivity are associated with the therapeutic response for gastric MALT lymphoma.2012

    • Author(s)
      Sawako Okada
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of CD44 variant expression as a recurrence marker of gastric cancer after endoscopic submucosal dissection.2012

    • Author(s)
      Kenro Hirata
    • Organizer
      The 10th annual meeting of the International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Helicobacter pylori and gastric cancer. Symposium 7 “Helicobacter pylori -Pathogenesis & Clinical Manifestation-“2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The 14th Meeting of International Conference on Ulcer Research (ICUR)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Dynamics of aquaporin-4 in gastric parietal cells in the gastric fundic mucosa of histamine type 2 receptor knockout mice with Helicobacter pylori infection.2012

    • Author(s)
      Seiichiro Fukuhara
    • Organizer
      The 14th Meeting of International Conference on Ulcer Research (ICUR)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Impaired heme oxygenase-1 upregulation induced decreased interstitial cells of Cajal in streptozotocin-induced diabetes model.2012

    • Author(s)
      Sachiko Mogami
    • Organizer
      The 14th Meeting of International Conference on Ulcer Research (ICUR)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] A comprehensive and active educational program for medical students to attract their interests toward research scientists at Keio University School of Medicine in Japan.2012

    • Author(s)
      Hirakata, M.
    • Organizer
      AMEE (Association for Medical Education in Europe) 2012
    • Place of Presentation
      Lyon, France
    • Related Report
      2012 Research-status Report
  • [Presentation] High frequency of overlap between functional dyspepsia, irritable bowel syndrome and overactive bladder.2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      2012 Joint International Neurogastroenterology and Motility Meeting (NGM2012)
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] The GerdQ is a useful tool for evaluating the patients’ satisfaction and identifying the patients with “unmet medical needs”.2012

    • Author(s)
      Sawako Okada
    • Organizer
      2012 Joint International Neurogastroenterology and Motility Meeting (NGM2012)
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] Improvement in the quality of life related to reflux symptoms after Helicobacter pylori eradication therapy.2012

    • Author(s)
      Kenro Hirata
    • Organizer
      2012 Joint International Neurogastroenterology and Motility Meeting (NGM2012)
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] Resistance to oxidative stress is a principal pathway for the survival and disease development of Helicobacter pylori. “Helicobacter pylori and Tissue Injury”2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      7th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Predictive Factors for the Increase in Size of Branch Duct-type Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Retrospective Cohort Study with a 6-year Follow-up.2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The American College of Gastroenterology Annual Scientific Meeting (ACG2012)
    • Place of Presentation
      Las Vegas, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Eradication of Helicobacter pylori with 10-day sitafloxacin-based triple therapy as a third- or fourth-line rescue therapy: preliminary results of open-label randomized trial.2012

    • Author(s)
      Hideki Mori
    • Organizer
      The American College of Gastroenterology Annual Scientific Meeting (ACG2012)
    • Place of Presentation
      Las Vegas, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Things to consider before submitting papers from Eastern authors to Western Journals – viewpoint of the Associate Editor of the “American Journal of Gastroenterology”.2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      Seoul International Digestive Disease Symposium 2012 (SIDDS2012)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] High eradication rates of Helicobacter pylori with sitafloxacin-based 10 days-triple therapy as a third-line treatment.2012

    • Author(s)
      Hideki Mori
    • Organizer
      Seoul International Digestive Disease Symposium 2012 (SIDDS2012)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] The Role of Helicobacter pylori infection in the disease entity of functional dyspepsia. Symposium 7 “Current Issues on Functional Dyspepsia”.2012

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      Seoul International Digestive Disease Symposium 2012 (SIDDS2012)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Trough Anti-Oxidative Stress Mechanism.

    • Author(s)
      Okada, S., Suzuki, H., Masaoka, T., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Saya, H., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Loss of Work Productivity Associated with Gastroesophageal Reflux Disease(GERD) in a Japanese Working Population.

    • Author(s)
      Suzuki, H., Matsuzaki, J., Masaoka, T., Okada, S., Inadomi, J., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Related Report
      2013 Annual Research Report
  • [Presentation] Application of 13C-acetic acid breath test for animals with impaired gastric motility.

    • Author(s)
      Fukuhara, S., Suzuki, H., Masaoka, T., Suemasu, S., Matsuzaki, J., Tsugawa, H., Okada, S., Hirata, K., Mori, H., Saito, Y., Mizushima, T., Hibi, T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of microRNA and cancer stem cells in gastric carcinogenesis

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Madrid
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Analysis of CagA serotypes with Helicobacter pylori multiplex serology.

    • Author(s)
      Michel, A., Wang, S., Zhang, W., Kist, M., Figueroa, G., Dondog, B., Suzuki, H., Pawlita, M.
    • Organizer
      The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Madrid
    • Related Report
      2013 Annual Research Report
  • [Presentation] Trends of second-line eradication therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area.

    • Author(s)
      Asaoka, D., Nagahara, A., Matsuhisa, T., Takahashi, S., Tokunaga, K., Kawai, T., Kawakami, K., Suzuki, H., Suzuki, M., Nishizawa, T., Kurihara, N., Ito, M., Sasaki, H., Omata, F., Mizuno, S., Torii, A., Ohkusa, T., Mine, T., Sakaki, N.
    • Organizer
      The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Madrid
    • Related Report
      2013 Annual Research Report
  • [Presentation] Influence of Helicobacter pylori on gastric carcinogenesis and functional disturbance.

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The International Joint Meeting of IBS Conference and Rome Committee in Tokyo
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Autophagy causing CagA degradation is triggered by cytoplasmic accumulation of low-density lipoprotein receptor-related protein-1 (LRP1) in gastric epithelial cells infected with H. pylori.

    • Author(s)
      Tsugawa, H., Matsuzaki, J., Okada, S., Fukuhara, S., Mori, H., Masaoka, T., Sato, A., Saya, H., Hatakayama, M., Hirayama, T., Suzuki, H.
    • Organizer
      UEGW2013
    • Place of Presentation
      Berlin
    • Related Report
      2013 Annual Research Report
  • [Presentation] H. pylori eradication for cancer prevention in clinical practice.

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      UEGW2013
    • Place of Presentation
      Berlin
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Involvement of stemness factors in the intestinal transdifferentiation of gastric epithelial cells.

    • Author(s)
      Fujii, Y., Suzuki, H., Aburatani, H., Hatakayama, M.
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD44v9 play a role to anti-tumor effect against human gastric cancer by trastuzumab.

    • Author(s)
      Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
    • Related Report
      2013 Annual Research Report
  • [Presentation] Escaped autophagy of H. pylori-derived oncoprotein CagA in gastric cancer stem-like cells.

    • Author(s)
      Hidekazu Suzuki
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Urayasu
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] High-level resistance to metronidazole for Helicobacter pylori is more prevalent in patients with postprandial distress syndrome.

    • Author(s)
      Matsuzaki, J., Suzuki, H., Mori, H., Tsugawa, H., Masaoka, T., Miyoshi, S., Fukuhara, S., Kanai, T.
    • Organizer
      The 4th Asian Pacific Single Topic Conference
    • Place of Presentation
      Tagaytay
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Impairment of apolipoprotein E evokes delayed gastric emptying through nitrergic dysfunction.

    • Author(s)
      Fukuhara, S., Suzuki, H., Masaoka, T., Tsugawa, H., Okada, S., Mori, H., Hirata, K., Matsuzaki, J., Iwasaki, E., Mizushima, T., Suzuki, M.
    • Organizer
      The 7th International Gastrointestinal Consensus Symposium (IGICS)
    • Place of Presentation
      Fukushima
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression of CD44 variant 9 contributes to 5-fluorouracil resistance in gastric cancer through anti-oxidative stress mechanism.

    • Author(s)
      Miyoshi, S., Suzuki, H., Tsugawa, H., Masaoka, T., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Kanani, T., Saya, H.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] The role of reactive oxygen species (ROS) in gastric carcinogenesis evoked by H. pylori infection.

    • Author(s)
      Tsugawa, H., Suzuki, H.
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Helicobacter pylori感染症 -酸化ストレス関連性病態機序-

    • Author(s)
      鈴木秀和
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 国民総除菌で胃がんを撲滅する

    • Author(s)
      鈴木秀和
    • Organizer
      第19回日本ヘリコバクター学会学術集会
    • Place of Presentation
      長崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 過敏性腸症候群(IBS)における大腸鏡の現状と今後の貢献の可能性

    • Author(s)
      水上健、小松弘一、鈴木秀和
    • Organizer
      第21回日本消化器病関連学会週間(JDDW2013)
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] FD症状を緩和する緑茶主成分Epigallocatechin gallateによる小胞体シャペロンGRP78抑制を介したnNOS活性化機構の検討

    • Author(s)
      正岡建洋、鈴木秀和、J.Tack
    • Organizer
      第21回日本消化器病関連学会週間(JDDW2013)
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] H. pylori感染症とFD

    • Author(s)
      鈴木秀和
    • Organizer
      第15回日本神経消化器病学会
    • Place of Presentation
      出雲
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小胞体シャペロンGRP78はnNOS発現を制御する

    • Author(s)
      正岡建洋、津川仁、福原誠一郎、三好佐和子、森英毅、Jan Tack, 金井隆典、鈴木秀和
    • Organizer
      第15回日本神経消化器病学会
    • Place of Presentation
      出雲
    • Related Report
      2013 Annual Research Report
  • [Presentation] 実験動物を用いたグレリン動態と胃排出障害

    • Author(s)
      岩崎栄典、鈴木秀和、最上祥子、正岡建洋、金井隆典、塚田信廣
    • Organizer
      第50回記念日本臨床生理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ピロリ菌感染症の診療を巡る最新知識

    • Author(s)
      鈴木秀和
    • Organizer
      第42回日本総合健診医学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Oxidative stress in stomach cancer CANCER:OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS (eds.) Victor R. Preedy, (ISBN :978-0-12-405205-5)2014

    • Author(s)
      Suzuki, H., Nishizawa, T.
    • Publisher
      Academic Press
    • Related Report
      2013 Final Research Report
  • [Book] eBook: Helicobacter pylori - A Worldwide Perspective 20142014

    • Author(s)
      Suzuki, H., Nishizawa, T., Hibi, T.
    • Publisher
      Bentham Science Publishers
    • Related Report
      2013 Annual Research Report
  • [Book] CANCER: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS2014

    • Author(s)
      Suzuki, H., Nishizawa, T.
    • Publisher
      Academic Press
    • Related Report
      2013 Annual Research Report
  • [Book] 胃・十二指腸の運動の特徴とその制御.専門医のための消化器病学第2版2013

    • Author(s)
      正岡建洋,鈴木秀和
    • Publisher
      医学書院東京
    • Related Report
      2013 Final Research Report
  • [Book] eBook: Helicobacter pylori : a worldwide perspective 20122013

    • Author(s)
      Hidekazu Suzuki
    • Publisher
      Bentham Science Publishers
    • Related Report
      2012 Research-status Report
  • [Book] eBook: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS2013

    • Author(s)
      Hidekazu Suzuki
    • Publisher
      Academic Press
    • Related Report
      2012 Research-status Report
  • [Book] 糖尿病性胃麻痺の病態機序の解明と新規治療戦略『ナテグリニド記念豊島研究教育資金平成14年度~23年度事業報告集』2012

    • Author(s)
      鈴木秀和,福原誠一郎,松崎潤太郎,岡田佐和子,津川仁,最上祥子,斎藤義正, Jan F. Tack,河瀬聡,岡野栄之
    • Publisher
      ナテグリニド記念豊島研究教育資金運営委員会
    • Related Report
      2013 Final Research Report
  • [Remarks] http://www.keio-med.jp/gastro/ugt/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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