| Project/Area Number |
24659145
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Takuma 東京大学, 医科学研究所, 特任助教 (30554505)
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| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 拡張型心筋症 / TLR |
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| Research Abstract |
We constructed Epithelial Membrane Protein 3 Transgenic mice (Emp3 Tg) which spontaneously suffered from DCM like heart symptoms. Emp3 Tg mice with CAG-Cre gene died within 6 months and most of them showed dilated heart atria and ventricles. However, deleting CAG-Cre gene from Emp3 Tg mice relieved them from DCM like symptoms. Considering that CAG-Cre did not show DCM like symptoms at all, Emp3 gene may exacerbate unknown abnormality in heart induced by Cre proteinoverexpression.
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