The role of innate immunity in Dilated Cardiomyopathy
Project/Area Number |
24659145
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Takuma 東京大学, 医科学研究所, 特任助教 (30554505)
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Project Period (FY) |
2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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Keywords | 拡張型心筋症 / TLR |
Research Abstract |
We constructed Epithelial Membrane Protein 3 Transgenic mice (Emp3 Tg) which spontaneously suffered from DCM like heart symptoms. Emp3 Tg mice with CAG-Cre gene died within 6 months and most of them showed dilated heart atria and ventricles. However, deleting CAG-Cre gene from Emp3 Tg mice relieved them from DCM like symptoms. Considering that CAG-Cre did not show DCM like symptoms at all, Emp3 gene may exacerbate unknown abnormality in heart induced by Cre proteinoverexpression.
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Report
(2 results)
Research Products
(7 results)
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[Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013
Author(s)
Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
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Journal Title
Int Immunol.
Volume: 25
Issue: 7
Pages: 413-422
DOI
Related Report
Peer Reviewed
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[Journal Article] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
Author(s)
Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
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Journal Title
Int Immunol.
Volume: 24
Issue: 10
Pages: 613-623
DOI
Related Report
Peer Reviewed
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