Establishment of the scoring system for predicting the prognosis of CKD patients.
| Project/Area Number |
24659279
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ABE Naoko 徳島大学, 大学病院, 特任助教 (70623271)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Toshio 徳島大学, ヘルスバイオサイエンス研究部, 教授 (60183498)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | CKD / 慢性腎臓病 / 予後 / バイオマーカー / 予後予測マーカー / podocyte / エクソゾーム |
|---|
| Research Abstract |
The worldwide rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal failure is a global public health problem. Current screening strategies, based on creatinine or albuminuria, fail to identify a considerable number of subjects with CKD. We first isolate exosomes from various CKD patients. We then examined the expression of podocyte-derived exosomal transcriptional factors (PDETFs) in urine from various CKD patients with gross proteinuria. While extent of albuminuria was not different, progressing renal diseases such as diabetic nephropathy exhibited high levels of urinary PDETFs. Glomerular expression of PDETFs was decreased in accordance with the amount of PDETFs in urine of the patients. The higher amount of urinary PDETFs secreted, the earlier the renal function declined. Evaluation and analysis of PDETFs would provide some clues to understanding the molecular linkage between CKD and CVD.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy.2013
Author(s)
Nagai K1, Miyoshi M, Kake T, Fukushima N, Matsuura M, Shibata E, Yamada S, Yoshikawa K, Kanayama HO, Fukawa T, Yamaguchi K, Izaki H, Mima A, Abe N, Araoka T, Murakami T, Kishi F, Kishi S, Tominaga T, Moriya T, Abe H, Doi T.
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Journal Title
PLoS One
Volume: 8(6)
Issue: 6
Pages: e66759-e66759
DOI
Related Report
Peer Reviewed
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