Weather changes and Migraine attacks: relationship, mechanism and strategy

• Project/Area Number: 24659292
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Keio University
• Principal Investigator: IWASHITA TATSUO 慶應義塾大学, 医学部, 講師 (30449011)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 片頭痛 / 三叉神経節 / CSD / 気象病 / 頭痛 / 気圧変化 / 気象 / 気象変化 / 皮質拡延性抑制 / ERK / TRPV1

Outline of Final Research Achievements

Migraineurs frequently report that their attacks may be precipitated by “triggers.” Many migraineurs thought that weather and barometric changes triggered their migraine attacks. We evaluated relationship between barometric change and clinical records of headache attacks. Results of our study suggest that barometric changes may contribute to onset of migraine attacks.
In this study, we investigated the response in the dura mater to nociceptive stimulation. We also examined the level of ERK phosphorylation in the trigeminal ganglion following cortical spreading depression (CSD), which is thought to play an important role in migraine pathophysiology. These results indicate that CSD can activate dural TRPV1 to send nociceptive signals to the trigeminal system, and they provide important clues regarding the relationship between CSD and the trigeminovascular system.

Research Products

• [Journal Article] 外来診療で注意すべき神経疾患の診断から治療まで「片頭痛」 (2015)
  • Author(s): 岩下達雄、清水利彦、鈴木則宏
  • Journal Title: 臨床と研究 Volume: 92
• [Journal Article] 頭痛診療最前線 薬物乱用頭痛と治療難渋頭痛への対処 (2014)
  • Author(s): 岩下達雄、清水利彦、鈴木則宏
  • Journal Title: Mebio Volume: 31 Pages: 24-30
• [Journal Article] 有痛性脳神経ニューロパチーおよび他の顔面痛－三叉神経痛 (2014)
  • Author(s): 岩下達雄
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 526-527
• [Journal Article] Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression (2013)
  • Author(s): Iwashita T, Shimizu T, Shibata M, Toriumi H, Ebine T, Funakubo M, Suzuki N.
  • Journal Title: Neuroscience Research Volume: 77 Pages: 110-119
  • Peer Reviewed
• [Journal Article] Differential cellular localization of antioxidant enzymes in the trigeminal ganglion (2013)
  • Author(s): H.Sato, M. Shibata, T. Shimizu, S. Shibata, H. Toriumi, T. Ebine, T. Kuroi, T. Iwashita, M. Funakubo, Y. Kayama, C. Akazawa, K. Wajima, T. Nakagawa, H. Okano, N. Suzuki
  • Journal Title: Neuroscience Volume: 248 Pages: 345-358
  • Peer Reviewed
• [Presentation] Trend of patients at a headache clinic (2015)
  • Author(s): Tatsuo Iwashita, Yoshiko Unno
  • Organizer: 17th Congress of International Headache Society
  • Place of Presentation: バレンシア（スペイン）
  • Year and Date: 2015-05-14 – 2015-05-17
• [Presentation] Effect of cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat (2013)
  • Author(s): 岩下 達雄
  • Organizer: International Headache Congress 2013
  • Place of Presentation: Boston, USA
• [Presentation] Effect of cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat (2013)
  • Author(s): 岩下 達雄
  • Organizer: Internationa Headache Congress 2013
  • Place of Presentation: Boston, USA
• [Book] 慢性頭痛の診療ガイドライン 市民版 (2014)
  • Author(s): 慢性頭痛の診療ガイドライン市民版作成小委員会（岩下達雄ほか）
  • Total Pages: 138
  • Publisher: 医学書院