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Weather changes and Migraine attacks: relationship, mechanism and strategy

Research Project

Project/Area Number 24659292
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionKeio University

Principal Investigator

IWASHITA TATSUO  慶應義塾大学, 医学部, 講師 (30449011)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords片頭痛 / 三叉神経節 / CSD / 気象病 / 頭痛 / 気圧変化 / 気象 / 気象変化 / 皮質拡延性抑制 / ERK / TRPV1
Outline of Final Research Achievements

Migraineurs frequently report that their attacks may be precipitated by “triggers.” Many migraineurs thought that weather and barometric changes triggered their migraine attacks. We evaluated relationship between barometric change and clinical records of headache attacks. Results of our study suggest that barometric changes may contribute to onset of migraine attacks.
In this study, we investigated the response in the dura mater to nociceptive stimulation. We also examined the level of ERK phosphorylation in the trigeminal ganglion following cortical spreading depression (CSD), which is thought to play an important role in migraine pathophysiology. These results indicate that CSD can activate dural TRPV1 to send nociceptive signals to the trigeminal system, and they provide important clues regarding the relationship between CSD and the trigeminovascular system.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Book (1 results)

  • [Journal Article] 外来診療で注意すべき神経疾患の診断から治療まで「片頭痛」2015

    • Author(s)
      岩下達雄、清水利彦、鈴木則宏
    • Journal Title

      臨床と研究

      Volume: 92

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 頭痛診療最前線 薬物乱用頭痛と治療難渋頭痛への対処2014

    • Author(s)
      岩下達雄、清水利彦、鈴木則宏
    • Journal Title

      Mebio

      Volume: 31 Pages: 24-30

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 有痛性脳神経ニューロパチーおよび他の顔面痛-三叉神経痛2014

    • Author(s)
      岩下達雄
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 526-527

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression2013

    • Author(s)
      Iwashita T, Shimizu T, Shibata M, Toriumi H, Ebine T, Funakubo M, Suzuki N.
    • Journal Title

      Neuroscience Research

      Volume: 77 Pages: 110-119

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential cellular localization of antioxidant enzymes in the trigeminal ganglion2013

    • Author(s)
      H.Sato, M. Shibata, T. Shimizu, S. Shibata, H. Toriumi, T. Ebine, T. Kuroi, T. Iwashita, M. Funakubo, Y. Kayama, C. Akazawa, K. Wajima, T. Nakagawa, H. Okano, N. Suzuki
    • Journal Title

      Neuroscience

      Volume: 248 Pages: 345-358

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Trend of patients at a headache clinic2015

    • Author(s)
      Tatsuo Iwashita, Yoshiko Unno
    • Organizer
      17th Congress of International Headache Society
    • Place of Presentation
      バレンシア(スペイン)
    • Year and Date
      2015-05-14 – 2015-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat2013

    • Author(s)
      岩下 達雄
    • Organizer
      International Headache Congress 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Effect of cortical spreading depression on the phosphorylation of ERK in the trigeminal ganglion of rat2013

    • Author(s)
      岩下 達雄
    • Organizer
      Internationa Headache Congress 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Research-status Report
  • [Book] 慢性頭痛の診療ガイドライン 市民版2014

    • Author(s)
      慢性頭痛の診療ガイドライン市民版作成小委員会(岩下達雄ほか)
    • Total Pages
      138
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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