| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In current study, we investigated the effect of internal radioactive cesium exposure on insulin sensitivity in male Wistar rats, whereby insulin sensitivity was measured directly using the hyperinsulinemic-euglycemic glucose clamp studies. Male Wistar rats were fed NCD, or HFD containing with either radioactive cesium or not, for 5 weeks. In the NCD fed rats, during the clamp studies, GIR, cHGO, and IS-GDR were no significant changes between two groups. On the other hand, in the HFD fed rats, the GIR and IS-GDR were significantly decreased in internal radioactive cesium exposure group compared to in the HFD control group. Furthermore, in the clamp studies, the adenovirus mediated adiponectin overexpression rats exhibited increased GIR and IS-GDR compared to the HFD fed internal radioactive cesium exposure rats.
In conclusion, the internal radiation by radioactive cesium exacerbates the HFD induced insulin resistance in male Wister rats, but adiponectin improves these affects.
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