Effects of Internal Radiation by Radioactive Cesium on glucose and insulin metabolism
| Project/Area Number |
24659570
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SATOH Hiroaki 福島県立医科大学, 医学部, 准教授 (20323595)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Satoru 福島医科大学, 医学部, 研究院 (50622792)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 放射性セシウム内部被爆 / インスリン抵抗性 / アディポネクチン / 糖尿病 / 放射性セシウム / 放射線 |
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| Outline of Final Research Achievements |
In current study, we investigated the effect of internal radioactive cesium exposure on insulin sensitivity in male Wistar rats, whereby insulin sensitivity was measured directly using the hyperinsulinemic-euglycemic glucose clamp studies. Male Wistar rats were fed NCD, or HFD containing with either radioactive cesium or not, for 5 weeks. In the NCD fed rats, during the clamp studies, GIR, cHGO, and IS-GDR were no significant changes between two groups. On the other hand, in the HFD fed rats, the GIR and IS-GDR were significantly decreased in internal radioactive cesium exposure group compared to in the HFD control group. Furthermore, in the clamp studies, the adenovirus mediated adiponectin overexpression rats exhibited increased GIR and IS-GDR compared to the HFD fed internal radioactive cesium exposure rats.
In conclusion, the internal radiation by radioactive cesium exacerbates the HFD induced insulin resistance in male Wister rats, but adiponectin improves these affects.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] White Blood Cell, Neutrophil, and Lymphocyte Counts in Individuals in the Evacuation Zone Designated by the Government After the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey2015
Author(s)
Sakai A, Ohira T, Hosoya M, Ohtsuru A, Satoh H, Kawasaki Y, Suzuki H, Takahashi A, Kobashi G, Ozasa K, Yasumura S, Yamashita S, Kamiya K, Abe M
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Journal Title
Journal of Epidemiology
Volume: 25
Issue: 1
Pages: 80-87
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Research Group of Diabetic Nephropathy MoHL, Welfare of J. Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes2014
Author(s)
Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
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Journal Title
Clinical and experimental nephrology.
Volume: -
Pages: 613-620
DOI
Related Report
Peer Reviewed
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[Journal Article] Life as an evacuee after the Fukushima Daiichi nuclear power plant accident is a cause of polycythemia: the Fukushima Health Management Survey.2014
Author(s)
Sakai A, Ohira T, Hosoya M, Ohtsuru A, Satoh H, Kawasaki Y, Suzuki H, Takahashi A, Kobashi G, Ozasa K, Yasumura S, Yamashita S, Kamiya K, Abe M, Fukushima Health Management Survey G
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Journal Title
BMC Public Health
Volume: 14
Pages: 1318-1318
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distribution of and factors contributing to chronic kidney disease in a middle-aged working population.2013
Author(s)
Furuichi K1, Shimizu M, Toyama T, Koya D, Koshino Y, Abe H, Mori K, Satoh H, Imanishi M, Iwano M, Yamauchi H, Kusano E, Fujimoto S, Suzuki Y, Okuda S, Kitagawa K, Iwata Y, Kaneko S, Nishi S, Yokoyama H, Ueda Y, Haneda M, Makino H, Wada T
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Journal Title
Environ Health Prev Med
Volume: 17
Pages: 466-476
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Yacon supplementation reduces plasma FFA and TNF- levels in type 2 diabetes2013
Author(s)
Hiroaki Satoh, Chihiro Tsukagoshi, Emi Ogata, Satoru Yamazaki, Yoshiyuki Sugaya, Noritaka Machii, Hiroyuki Hirai, Akihiro Kudoh, Koji Hasegawa, Shinichi Nakajima, Tsuyoshi Watanabe.
Organizer
第45回日本動脈硬化学会総会・学術集会
Place of Presentation
東京
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