• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Treatment of subacute spinal injury by heparin-containing matrix combined with bFGF

Research Project

Project/Area Number 24659792
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionThe Tazuke Kofukai

Principal Investigator

HIRAI Tatsuya  公益財団法人田附興風会, 医学研究所第5研究部, 研究員 (50465952)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yoshihisa  公益財団法人田附興風会, 医学研究所第5研究部, 研究主幹 (30243025)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords再生医療 / 脊髄損傷 / 人工材料 / 成長因子 / ヘパリン/アルギン酸 / 繊維芽細胞成長因子 / 骨髄中単核球 / bFGF / ヘパリン/アルギン酸ゲル
Outline of Final Research Achievements

One of the problems concerning subacute spinal injury is the cavity formation in spine nerve. In the present study, we applied heparin containing novel matrix combined with basic fibroblastic growth factor (bFGF) to prevent the cavity formation. The bFGF possesses the affinity to heparin and is expected to stay on the matrix in vivo for a long time. The bFGF-attached heparin-containing matrix demonstrated the effect of bFGF in vivo for one month under physical condition. This novel matrix with bFGF strongly promoted nerve regeneration in partially dissected rat spinal cord. It was also found that this novel matrix had an affinity to the host spinal cord tissues. Elongation of axonal sprouts into the dissected nerve site was observed 8 weeks after surgery.Taken together, our novel matrix combined with bFGF may provide a new strategy to treat spinal cord injury.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (1 results) Presentation (7 results)

  • [Journal Article] Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture2014

    • Author(s)
      鈴木義久
    • Journal Title

      Restor Neural Neurosci

      Volume: インプレス

    • Related Report
      2013 Research-status Report
  • [Presentation] bFGF徐放アルギン酸ゲルを用いた脊髄損傷後の神経再生の評価2014

    • Author(s)
      平井達也
    • Organizer
      第23回日本形成外科学会基礎学術集会
    • Place of Presentation
      長野県松本市キッセイ文化ホ-ル
    • Year and Date
      2014-10-08 – 2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] bFGF徐放効果を持ったヘパリン/アルギン酸を用いたラット急性期脊髄損傷での神経再生の評価の追加報告2013

    • Author(s)
      平井達也
    • Organizer
      第22回日本形成外科学会学術総会
    • Place of Presentation
      新潟県新潟市朱鷺メッセ
    • Related Report
      2013 Research-status Report
  • [Presentation] 自家骨髄由来細胞を用いた脊髄損傷の治療法の確立2013

    • Author(s)
      鈴木義久
    • Organizer
      第22回日本形成外科学会学術総会
    • Place of Presentation
      新潟県新潟市朱鷺メッセ
    • Related Report
      2013 Research-status Report
  • [Presentation] 磁場を用いた中枢及び末梢神経の再生2013

    • Author(s)
      石川奈美子
    • Organizer
      第22回日本形成外科学会学術総会
    • Place of Presentation
      新潟県新潟市朱鷺メッセ
    • Related Report
      2013 Research-status Report
  • [Presentation] bFGF徐放ヘパリン・アルギン酸ゲルを用いたラット急性期脊髄損に対する神経の評価2013

    • Author(s)
      平井達也
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      神奈川県横浜市 パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] bFGF徐放ヘパリン・アルギン酸ゲルを用いたラット急性期脊髄損傷治療の評価2012

    • Author(s)
      平井達也
    • Organizer
      第21回日本形成外科学会基礎学術集会
    • Place of Presentation
      福島県耶麻群猪苗代町 ホテルリステル猪苗代
    • Related Report
      2012 Research-status Report
  • [Presentation] 脊髄損傷治療法の確立2012

    • Author(s)
      鈴木義久
    • Organizer
      第21回日本形成外科学会基礎学術集会
    • Place of Presentation
      福島県耶麻群猪苗代町 ホテルリステル猪苗代
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi