| Project/Area Number |
24659819
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Naoki 岩手医科大学, 歯学部, 准教授 (20190100)
OTSU Keishi 岩手医科大学, 歯学部, 助教 (60509066)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | iPS細胞 / 奇形種 / 歯 / 発生 / 再生医学 / 再生 |
|---|
| Research Abstract |
iPS cells-derived teratomas do not contain tooth germ. Therefore, we hypothesized that we could induce tooth development from the stem cells in the teratomas by the introduction of exogenous tooth morphogenesis-related genes. During teratoma formation, iPS cells differentiated into epithelial cells and formed various types of epithelial tissue. Our results also indicate that these epithelia included epithelial stem/progenitor cell marker positive cells. Further, we succeeded in the introduction of tooth germ epithelium specific gene, Sp-6, into the teratomas, and which induced epithelial differentiation. These results will develop innovations for the study of tooth regeneration.
|
