| Project/Area Number |
24659836
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
TERAO Yutaka 新潟大学, 医歯学系, 教授 (50397717)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Shigetada 大阪大学, 大学院歯学研究科, 教授 (50273694)
NAKATA Masanobu 大阪大学, 大学院歯学研究科, 准教授 (90444497)
SUMITOMO Tomoko 大阪大学, 大学院歯学研究科, 助教 (50423421)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アジュバント / DNAオリガミ / ワクチン |
|---|
| Research Abstract |
Recently, pathogenic microorganisms acquired drug-resistance, and they are spreading throughout the world. Antibiotics were presented as "magic bullets" against infectious diseases in the 20th century, however, the heavy usage of antibiotics has led to the appearance of drug-resistant microorganisms. Thus, it has become difficult to treat most infantile diarrhea with basic antibiotics in the developing countries. Now, it is important to develop and improve the enteric and general immune activators on the basis of fundamental investigations. In this proposal, we focus on a CpG motif among the DNA sequence. The CpG motif is observed at high frequency in the genomes of pathogenic microorganisms. It works as an immune activator to boost production of antigen-specific immune responses. In this study, we constructed "DNA origami" immune activators being fixed the GpG motifs to the outside using M13 DNA, aiming to obtain the immunopotentiating effect.
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