Development of novel nanomedicine for metabolic syndrome

• Project/Area Number: 24680053
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: Yoshioka Yasuo 大阪大学, 微生物病研究所, 特任准教授(常勤) (00392308)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000); Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: ナノ粒子 / フラーレン / ナノメディシン / メタボリックシンドローム / 慢性炎症疾患 / 安全性

Outline of Final Research Achievements

Fullerene C60 derivatives are the most promising nanomaterials because of its unique ability to scavenge large numbers of free radicals. Therefore fullerene C60 derivatives with antioxidant effects have been expected to apply to the medicine for inflammatory disease. Here I showed that Fullerene C60 derivatives might be useful preventive therapeutics for metabolic syndrome.

Research Products

• [Presentation] Elucidation of immunotoxicity of nanoparticles for developing the sustainable nanotechnology (2015)
  • Author(s): Yoshioka Y, Higashisaka K, Tsutsumi Y
  • Organizer: The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
  • Place of Presentation: ハワイ（ホノルル）
  • Year and Date: 2015-12-15
  • Int'l Joint Research / Invited
• [Presentation] Sustainable Nanotechnologyを目指したナノ安全科学研究 (2015)
  • Author(s): 吉岡靖雄、東阪和馬、堤 康央
  • Organizer: 第42回日本毒性学会学術年会
  • Place of Presentation: 金沢
  • Year and Date: 2015-06-29
  • Invited
• [Presentation] Understanding of immunotoxicity of engineered nanomaterials for the sustainable nanotechnology. (2015)
  • Author(s): Yoshioka Y, Tsutsumi Y
  • Organizer: The 31st International Congress on Occupational Health
  • Place of Presentation: 韓国（ソウル）
  • Year and Date: 2015-06-02
  • Int'l Joint Research / Invited
• [Presentation] C60フラーレン誘導体の免疫抑制剤としての有効性評価～in vitroにおける評価～ (2014)
  • Author(s): 平井敏郎, 吉岡靖雄, 宇髙麻子, 大江知之, 青島央江, 小久保 研, 大島 巧, 増野匡彦, 東阪和馬, 堤 康央
  • Organizer: 第30回日本DDS学会
  • Place of Presentation: 東京都港区
  • Year and Date: 2014-07-30 – 2014-07-31
• [Presentation] Fullerene C60 derivatives suppress the acquired immune responses. (2014)
  • Author(s): Yoshioka Y., Udaka A., Hirai T., Aoshima H., Kokubo K., Oshima T., Ohe T., Mashino T., Tsunoda S., Higashisaka K., Tsutsumi Y.
  • Organizer: Immunology 2014
  • Place of Presentation: Pittsburgh (USA)
  • Year and Date: 2014-05-02 – 2014-05-06
• [Presentation] ナノマテリアルの物性-動態-生体影響の連関評価 (2013)
  • Author(s): 吉岡靖雄, 堤 康央
  • Organizer: 第40回日本毒性学会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] The importance of systemic nanotoxicological and toxicokinetic analysis for ensuring the safety of nanomaterials (2013)
  • Author(s): Yoshioka Y, Tsutsumi Y
  • Organizer: The XIII International Congress of Toxicology
  • Place of Presentation: 韓国
  • Invited
• [Presentation] ナノマテリアルの安全性確保に資する 微粒子の免疫毒性評価 (2013)
  • Author(s): 吉岡靖雄, 堤 康央
  • Organizer: 第20回日本免疫毒性学会学術年会
  • Place of Presentation: 東京
  • Invited
• [Presentation] ナノマテリアルの持続的な安全使用に向けたナノ安全科学研究 (2013)
  • Author(s): 吉岡靖雄
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川(パシフィコ横浜)(招待講演)
• [Presentation] The importance of nano-safety science for ensuring the safety of nanomaterials (2013)
  • Author(s): Yasuo Yoshioka Y
  • Organizer: The 2<nd>symposium of"Carbon Nanoforms"
  • Place of Presentation: 茨城(産業技術総合研究所)(招待講演)
• [Presentation] 水酸化フラーレンのナノ安全科学評価と経口サブナノ医薬への展開1-in vitroにおける細胞毒性及び抗炎症作用の検討- (2012)
  • Author(s): 平茉由
  • Organizer: 第62回日本薬学会近畿支部総会・大会
  • Place of Presentation: 兵庫(武庫川女子大学)
  • Year and Date: 2012-10-20
• [Presentation] 水酸化フラーレンのナノ安全科学評価と経口サブナノ医薬への展開1～in vitroにおける抗炎症作用の評価～ (2012)
  • Author(s): 平茉由
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 北海道(札幌コンベンションセンター)
• [Presentation] 経口投与型サブナノ医薬の開発に向けた水酸化フラーレンの安全性及び有効性評価 (2012)
  • Author(s): 山下浩平
  • Organizer: 第11回ファーマバイオフォーラム
  • Place of Presentation: 福岡(九州大学)
• [Presentation] Safety science of fullerenol C_<60> for developing nanomedicine 1 -anti-in flammatory effect of fullerenol C_<60> in vitro (2012)
  • Author(s): Mayu Taira
  • Organizer: The 61_<th>International Conference on Nanotoxicology
  • Place of Presentation: 中国
• [Presentation] Safety science of fullerenol C60 for developing nanomedicine 2 -safety and efficacy assessment of fullerenol C60 1n oral exposure (2012)
  • Author(s): Michihiko Aoyama
  • Organizer: The 6_<th>International Conference on Nanotoxicology
  • Place of Presentation: 中国
• [Presentation] The basic safety assessment of fullerenol C60 after oral exposure (2012)
  • Author(s): Kohei Yamashita
  • Organizer: SETAC Asia/Pacific 2012
  • Place of Presentation: 熊本(ANAホテル熊本)
• [Presentation] Association between neutrophilia and inflammatory responses for ensuring safety of nanomaterials (2012)
  • Author(s): Kazuma Higashisaka
  • Organizer: International Congress on Safety of Engineered Nanopart icles and Nanotechnologies (SENN2012)
  • Place of Presentation: フィンランド