| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
Plants and cyanobacteria form oxygen molecules required for life on the earth. Tis reaction is performed by light-induced electron transfer and water-splitting reaction of oxygen-evolving center, the so-called Mn4CaO5-cluster in photosystem II (PSII). The chloride ion (Cl-) in PSII is known to be an essential co-factor in the water-splitting reaction, however, the reaction is inhibited when Cl- is replaced with iodine ion (I-). We analyzed the crystal structure of iodine-substituted PSII (I-PSII) to elucidate the inhibition mechanism of the water-splitting reaction by I- and the associated structural changes of the Mn4CaO5-cluster. In this study, we conformed the dynamic structural changes in the Mn4CaO5-cluster and reduction reaction of the cluster upon I- substitution.
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