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Basic study on the creation of novel therapeutic approach by the regulation of the metabolism of branched chain amino acids

Research Project

Project/Area Number 24688015
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Food science
Research InstitutionKyoto University

Principal Investigator

Goto Tsuyoshi  京都大学, (連合)農学研究科(研究院), 准教授 (10550311)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Keywords肥満 / 脂肪組織 / 分岐鎖アミノ酸 / アミノ酸 / 脂肪細胞 / PPAR / 食品
Outline of Final Research Achievements

In this study, we investigated the relationship between obesity and amino acids metabolism, including branched-chain amino acids (BCAAs). We showed following findings. 1. Mice lacking Bcat2, a gene related to BCAAs metabolism, in adipose tissue didn't show any changes in non-fasting plasma BCAAs levels and adiposity, suggesting that the increment of plasma BCAAs levels under obesity condition didn't depend only on the down-regulation of BCAAs metabolism in obese adipose tissues. 2. Agonists of PPARγ, a master regulator of adipocyte differentiation, were involved in the regulation of whole body amino acid metabolism via the activation of PPARγ in adipocytes. 3. Activation of PPARα in adipose tissues lowered plasma BCAAs levels under high-fat diet feeding condition.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (4 results)

  • [Int'l Joint Research] University of Ulsan(韓国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice.2016

    • Author(s)
      Sakamoto T, Nitta T, Maruno K, Yeh YS, Kuwata H, Tomita K, Goto T, Takahashi N, Kawada T.
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: - Issue: 8 Pages: E676-E687

    • DOI

      10.1152/ajpendo.00028.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes.2016

    • Author(s)
      Goto T, Naknukool S, Yoshitake R, Hanafusa Y, Tokiwa S, Li Y, Sakamoto T, Nitta T, Kim M, Takahashi N, Yu R, Daiyasu H, Seno S, Matsuda H, Kawada T.
    • Journal Title

      Cytokine.

      Volume: 77 Pages: 107-114

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.2015

    • Author(s)
      Minji Kim, Tsuyoshi Goto, Rina Yu, Kunitoshi Uchida, Makoto Tominaga, Yuriko Oi-Kano, Nobuyuki Takahashi, and Teruo Kawada
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 18013-18013

    • DOI

      10.1038/srep18013

    • NAID

      120005690138

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α.2015

    • Author(s)
      Takahashi H, Goto T, Yamazaki Y, Kamakayi K, Hirata M, Suzuki H, Shibata D, Takahashi N, Kawada T.
    • Journal Title

      J Lipid Res.

      Volume: 56 Issue: 2 Pages: 254-265

    • DOI

      10.1194/jlr.m052464

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic acid activates peroxisome proliferator-activated receptor γ in adipocytes.2015

    • Author(s)
      Takahashi H, Hara H, Goto T, Kamakari K, Wataru N, Mohri S, Takahashi N, Suzuki H, Shibata D, Kawada T.
    • Journal Title

      Lipids

      Volume: 50 Issue: 1 Pages: 3-12

    • DOI

      10.1007/s11745-014-3972-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARgamma and stimulates adipogenesis.2015

    • Author(s)
      Goto T, Kim YI, Furuzono T, Takahashi N, Yamakuni K, Yang HE, Li Y, Ohue R, Nomura W, Sugawara T, Yu R, Kitamura N, Park SB, Kishino S, Ogawa J, Kawada T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 459 Issue: 4 Pages: 597-603

    • DOI

      10.1016/j.bbrc.2015.02.154

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-chain free fatty acid profiling analysis by liquid chromatography-mass spectrometry in mouse treated with peroxisome proliferator-activated receptor α agonist.2013

    • Author(s)
      Takahashi H, Suzuki H, Suda K, Yamazaki Y, Takino A, Kim YI, Goto T, Iijima Y, Aoki K, Shibata D, Takahashi N, Kawada T.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 77 Pages: 2288-2293

    • NAID

      130003381942

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.2013

    • Author(s)
      Goto T, Kim YI, Takahashi N, Kawada T.
    • Journal Title

      Mol Nutr Food Res.

      Volume: 57 Issue: 1 Pages: 20-33

    • DOI

      10.1002/mnfr.201200522

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells.2013

    • Author(s)
      Tsuyoshi Goto, et al.
    • Journal Title

      Mol Nutr Food Res.

      Volume: (印刷中) Issue: 8 Pages: 1435-45

    • DOI

      10.1002/mnfr.201200573

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 核内受容体PPARα活性化因子による代謝異常改善機構の解析2015

    • Author(s)
      後藤剛、高橋春弥、高橋信之、河田照雄
    • Organizer
      第36回 日本肥満学会
    • Place of Presentation
      名古屋国際会議場 (愛知、名古屋)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Xanthoangerol and 4-hydroxyderrcin supress obesity-induced inflammatory responses2015

    • Author(s)
      Li Y, Goto T, Ikutani R, Lin S, Takahashi N, Takahashi H, Jheng HF, Murakami S, Yu R, Kawada T.
    • Organizer
      The 8th Asis-Oceania Conference on Obesity
    • Place of Presentation
      Nagoya Congress Center (Aichi, Nagoya)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of IL-1 beta on UCP1 expression in adipocytes2015

    • Author(s)
      Hanafusa Y, Yoshitake R, Naknukool S, Sakamoto T, Daiyasu H, Seno S, Matsuda H, Goto T, Takahashi N, Kawada T.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama (Kanagawa, Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外因性因子による褐色脂肪細胞 機能亢進機構の解析2015

    • Author(s)
      後藤 剛、高橋 信之、河田 照雄
    • Organizer
      日本農芸化学会2015大会
    • Place of Presentation
      岡山大学 津島キャンパス
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満に伴い脂肪組織に浸潤したマクロファージがベージュ脂肪細胞発現を抑制する2015

    • Author(s)
      新田 貴大、坂本 智弥、丸野 晃嗣、後藤 剛、高橋 信之、河田 照雄
    • Organizer
      日本農芸化学会2015大会
    • Place of Presentation
      岡山大学 津島キャンパス
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] IL-1βが白色脂肪細胞におけるUCP1発現に及ぼす影響2014

    • Author(s)
      吉竹 里依子、Naknukool Supaporn、花房 祐希、坂本 智弥、後藤 剛、高橋 信之、大安 裕美、瀬尾 茂人、松田 秀雄、河田 照雄
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎市 シーガイアコンベンションセンター
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炎症誘発性一酸化窒素が白色脂肪細胞組織におけるPPARα発現に及ぼす作用2014

    • Author(s)
      青木 ゆめこ、後藤 剛、高橋 信之、河田 照雄
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎市 シーガイアコンベンションセンター
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] PPARαアゴニストの薬理作用におけるFGF21の役割2014

    • Author(s)
      平田 茉莉子、後藤 剛、高橋 信之、伊藤 信行、河田 照雄
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎市 シーガイアコンベンションセンター
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] PPARsアゴニストによる白色脂肪組織の褐色化に関する研究2014

    • Author(s)
      平田 茉莉子、後藤 剛、新田 貴大、高橋 信之、河田 照雄
    • Organizer
      第68回日本栄養・食糧学会
    • Place of Presentation
      江別市 酪農学園大学
    • Year and Date
      2014-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 褐色脂肪細胞機能と食品由来因子 細胞・モデル動物を用いた探索・評価法2014

    • Author(s)
      後藤 剛
    • Organizer
      第68回日本栄養・食糧学会
    • Place of Presentation
      江別市 酪農学園大学
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Farnesol Improves Obesityinduced Metabolic Disorders Via PPARαdependent And independent Pathways.2014

    • Author(s)
      後藤 剛
    • Organizer
      12tha International Congress on Obesity
    • Place of Presentation
      マレーシア クアラルンプール
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学 大学院農学研究科 食品生物科学専攻 食品分子機能学分野

    • URL

      http://www.foodfunc.kais.kyoto-u.ac.jp/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 食品分子機能学分野HP

    • URL

      http://www.foodfunc.kais.kyoto-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 食品分子機能学分野HP

    • URL

      http://www.foodfunc.kais.kyoto-u.ac.jp/results.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.foodfunc.kais.kyoto-u.ac.jp/index.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2022-01-31  

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