The functional analysis of kidney stone-phagocytosis activity by the macrophages and the application to dissolution therapy.

• Project/Area Number: 24689060
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: OKADA Atsushi 名古屋市立大学, 医学(系)研究科(研究院), 講師 (70444966)
• Research Collaborator: KOHRI Kenjiro 名古屋市立大学, 大学院医学研究科, 学長 (30122047) ; TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733) ; YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 助教 (80551267) ; HIROSE Masahito 名古屋市立大学, 大学院医学研究科, 研究員 (70529172) ; NIIMI Kazuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (70551274) ; TAGUCHI Kazumi 名古屋市立大学, 大学院医学研究科, 研究員 (00595184) ; FUJII Yasuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (30566229)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000); Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2012: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
• Keywords: 尿路結石 / マクロファージ / op/opマウス / マルチプレックス解析 / 結晶貪食モデル / op/op / M-CSF / M2 / 結晶貪食 / 尿路結石症 / 結石消失現象

Outline of Final Research Achievements

This study is aimed establish a technique to control the function of macrophages as a new prevention factor for kidney stone formation by positioning that the main constituent of the “stone elimination” phenomenon is "the kidney stone-phagocytosis activity" of Mφ, and we performed three following studies using an animal model, human specimen and culture model.
[1] We identified stone-preventive ability of M-CSF-derived M2-Mφ by increased stone formation in Mφ-deficient mice (op/op). [2] We showed the possibility that lower urinary IL-4 related in stone formation using multiplex analysis. [3] Using culture Mφ, we identified that the englobed COM crystals were revealed in lysosomes of Mφ with acidified environment and disappeared over time.

Research Products

• [Journal Article] Endoscopic combined intrarenal surgery for large calculi: Simultaneous use of flexible ureteroscopy and mini-percutaneous nephrolithotomy overcomes the disadvantageous of percutaneous nephrolithotomy monotherapy. (2014)
  • Author(s): Hamamoto Shuzo, Yasui Takahiro, Okada Atsushi, Taguchi Kazumi, Kawai Noriyasu, Ando Ryosuke, Mizuno Kentaro, Kubota Yasue, Kamiya Hiroyuki, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: Journal of Endourology Volume: 28 Issue: 1 Pages: 28-33
  • DOI: 10.1089/end.2013.0361
  • Peer Reviewed / Open Access
• [Journal Article] Impact of prostate weight on perioperative outcomes of robot-assisted laparoscopic prostatectomy with a posterior approach to the seminal vesicle. (2014)
  • Author(s): Yasui Takahiro, Tozawa Keiichi, Kurokawa Satoshi, Okada Atsushi, Mizuno Kentaro, Umemoto Yukihiro, Kawai Noriyasu, Sasaki Shoichi, Hayashi Yutaro, Kojima Yoshiyuki, Kohri Kenjiro
  • Journal Title: Bio Med Central Urology Volume: 14 Issue: 1 Pages: 6-6
  • DOI: 10.1186/1471-2490-14-6
  • Peer Reviewed
• [Journal Article] Increased crystal-cell interaction in vitro under co-culture of renal tubular cells and adipocytes by in vitro co-culture paracrine systems simulating metabolic syndrome. (2014)
  • Author(s): Ichikawa J, Okada A, Taguchi K, Fujii Y, Zuo L, Niimi K, Hamamoto S, Kubota Y, Umemoto Y, Itoh Y, Yasui T, Kawai N, Tozawa K, Kohri K.
  • Journal Title: Urolithiasis. Volume: 42 Issue: 1 Pages: 17-28
  • DOI: 10.1007/s00240-013-0612-5
  • Peer Reviewed
• [Journal Article] Laparoendoscopic Single-Site Partial Nephrectomy Without Hilar Clamping Using a Microwave Tissue Coagulator. (2014)
  • Author(s): Kawai Noriyasu, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: Journal of Endourology Volume: 28(2) Issue: 2 Pages: 184-190
  • DOI: 10.1089/end.2013.0135
  • Peer Reviewed
• [Journal Article] Long-term follow-up of nephrotoxicity in rats administered both melamine and cyanuric acid. (2014)
  • Author(s): Yasui T, Kobayashi T, Okada A, Hamamoto S, Hirose M, Mizuno K, Kubota Y, Umemoto Y, Kawai N, Tozawa K, Gao B, Kohri K.
  • Journal Title: BMC Res Notes. Volume: 7 Issue: 1 Pages: 87-87
  • DOI: 10.1186/1756-0500-7-87
  • Peer Reviewed / Open Access
• [Journal Article] A Paracrine Mechanism Involving Renal Tubular Cells, Adipocytes, and Macrophages Promotes Kidney Stone Formation in a Simulated Metabolic Syndrome Environment. (2014)
  • Author(s): Li Zuo, Okada Atsushi, Yasui Takahiro, Taguchi Kazumi, Ito Yasuhiko, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Hamamoto Shuzo, Ando Ryosuke, Itoh Yasunori, Zuo Jiangang, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: The Journal of Urology Volume: 191 Issue: 6 Pages: 1906-1912
  • DOI: 10.1016/j.juro.2014.01.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel effect of the inhibitor of mitochondrial cyclophilin D activation, N-methyl-4-isoleucine cyclosporin, on renal calcium crystallization (2014)
  • Author(s): Niimi K, Yasui T, Okada A, Hirose Y, Kubota Y, Umemoto Y, Kawai N, Tozawa K, Kohri K
  • Journal Title: Int J Urol Volume: ― Issue: 7 Pages: 707-13
  • DOI: 10.1111/iju.12425
  • Peer Reviewed
• [Journal Article] Gemcitabine and docetaxel, an effective second-line chemotherapy for lung metastasis of urothelial carcinoma. (2014)
  • Author(s): Naiki Taku, Kawai Noriyasu, Hashimoto Yoshihiro, Okamura Takehiko, Ando Ryosuke, Yasui Takahiro, Okada Atsushi, Etani Toshiki, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: International Journal of Clinical Oncology Volume: 19 Issue: 3 Pages: 516-522
  • DOI: 10.1007/s10147-013-0574-1
  • Peer Reviewed
• [Journal Article] Developments in the technique of endoscopic combined intrarenal surgery in the prone split-leg position. (2014)
  • Author(s): Shuzo Hamamoto, Takahiro Yasui, Atsushi Okada, Mitsuru Takeuchi, Kazumi Taguchi, Yuta Shibamoto, Yutaka Iwase, Noriyasu Kawai, Keiichi Tozawa, Kohri Kenjiro
  • Journal Title: Urology Volume: 84 Issue: 3 Pages: 565-570
  • DOI: 10.1016/j.urology.2014.04.020
  • Peer Reviewed / Open Access
• [Journal Article] Pitfalls of robot-assisted radical prostatectomy: A comparison of positive surgical margins between robotic and laparoscopic surgery. (2014)
  • Author(s): Tozawa Keiichi, Yasui Takahiro, Umemoto Yukihiro, Mizuno Kentaro, Okada Atsushi, Kawai Noriyasu, Takahashi Satoru, Kohri Kenjiro
  • Journal Title: International Journal of Urology Volume: 21 Issue: 10 Pages: 976-979
  • DOI: 10.1111/iju.12492
  • Peer Reviewed
• [Journal Article] Effect of Adiponectin on Kidney Crystal Formation in Metabolic Syndrome Model Mice via Inhibition of Inflammation and Apoptosis (2013)
  • Author(s): Fujii Y, Okada A, Yasui T, Niimi K,Hamamoto S, Hirose M, Kubota Y, Tozawa K, Hayashi Y, Kohri K.
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e61343-e61343
  • DOI: 10.1371/journal.pone.0061343
  • Peer Reviewed
• [Journal Article] The association between the incidence of urolithiasis and nutrition based on Japanese National Health and Nutrition Surveys (2013)
  • Author(s): Yasui T, Okada A, Hamamoto S, Hirose M, Ando R, Kubota Y, Tozawa K, Hayashi Y, Gao B, Suzuki S, Kohri K
  • Journal Title: Urolithiasis Volume: 41 Issue: 3 Pages: 217-24
  • DOI: 10.1007/s00240-013-0567-6
  • Peer Reviewed
• [Journal Article] A replication study for three nephrolithiasis loci at 5q35.3, 7p14.3 and 13q14.1 in the Japanese population (2013)
  • Author(s): Yasui T, Okada A, Urabe Y, Usami M, Mizuno K, Kubota Y, Tozawa K, Sasaki S, Higashi Y, Sato Y, Kubo M, Nakamura Y, Matsuda K, Kohri K
  • Journal Title: J Hum Genet Volume: 58 Issue: 9 Pages: 588-93
  • DOI: 10.1038/jhg.2013.59
  • NAID: 10031195294
  • Peer Reviewed
• [Journal Article] Oxygen nano-bubble water reduces calcium oxalate deposits and tubular cell injury in ethylene glycol-treated rat kidney. (2013)
  • Author(s): Hirose Y, Yasui T, Taguchi K, Fujii Y, Niimi K, Hamamoto S, Okada A, Kubota Y, Kawai N, Itoh Y, Tozawa K, Sasaki S, Kohri K.
  • Journal Title: Urolithiasis. Volume: 41 Issue: 4 Pages: 279-294
  • DOI: 10.1007/s00240-013-0576-5
  • Peer Reviewed
• [Journal Article] Impact of official technical training for urologists on the efficacy of shock wave lithotripsy. (2013)
  • Author(s): Okada A, Yasui T, Taguchi K, Niimi K, Hirose Y, Hamamoto S, Ando R, Kubota Y, Umemoto Y, Tozawa K, Sasaki S, Hayashi Y, Kohri K.
  • Journal Title: Urolithiasis. Volume: 41 Issue: 6 Pages: 287-492
  • DOI: 10.1007/s00240-013-0586-3
  • Peer Reviewed
• [Journal Article] Efficacy of retroperitoneal laparoscopic ureterolithotomy for the treatment of large proximal ureteric stones and its impact on renal function. (2013)
  • Author(s): Yasui T, Okada A, Hamamoto S, Taguchi K, Ando R, Mizuno K, Itoh Y, Tozawa K, Hayashi Y, Kohri K.
  • Journal Title: Springerplus. Volume: 2 Issue: 1 Pages: 600-600
  • DOI: 10.1186/2193-1801-2-600
  • Peer Reviewed
• [Journal Article] Mitocondrial permeability transition pore opening induces the initial process of renal calcium crystallization (2012)
  • Author(s): Niimi Kazuhiro, Yasui Takahiro, Hirose Masahito, Hamamoto Shuzo, Itoh Yasunori, Okada Atsushi, Kubota Yasue, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
  • Journal Title: Free Radical Biology & Medicine Volume: 52 Issue: 7 Pages: 1207-1217
  • DOI: 10.1016/j.freeradbiomed.2012.01.005
  • Peer Reviewed
• [Journal Article] Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice (2012)
  • Author(s): Hirose M, Tozawa K, Okada A, Hamamoto S, Higashibata Y, Gao B, Hayashi Y, Shimizu H, Kubota Y, Yasui T, Kohri K
  • Journal Title: Urol Res. Volume: 40 Issue: 2 Pages: 121-9
  • DOI: 10.1007/s00240-011-0400-z
  • Peer Reviewed
• [Journal Article] Pioglitazone, a peroxisome proliferator activated receptor γ agonist, decreases renal crystal deposition, oxidative stress and inflammation in hyperoxaluric rats (2012)
  • Author(s): Taguchi K
  • Journal Title: J Urol Volume: 188 Issue: 3 Pages: 1002-1011
  • DOI: 10.1016/j.juro.2012.04.103
  • Peer Reviewed
• [Journal Article] Biomolecular mechanism of urinary stone formation involving osteopontin (2012)
  • Author(s): Kohri K
  • Journal Title: Urol Res Volume: 40 Issue: 6 Pages: 623-637
  • DOI: 10.1007/s00240-012-0514-y
  • Peer Reviewed
• [Journal Article] わが国の第1号膀胱鏡を訪ねて (2012)
  • Author(s): 岡田淳志
  • Journal Title: 臨床泌尿器科 Volume: 66 Pages: 174-177
• [Journal Article] 尿路結石症の遺伝子多形 (2012)
  • Author(s): 安井孝周、濱本周造、岡田淳志、郡健二郎
  • Journal Title: 臨床検査 Volume: 56 Pages: 303-308
• [Journal Article] 結石と炎症生体反応 (2012)
  • Author(s): 戸澤啓一、安井孝周、岡田淳志、郡健二郎
  • Journal Title: 臨床検査 Volume: 56 Pages: 255-259
• [Journal Article] 尿路結石の病態解明による再発予防への展望 (2012)
  • Author(s): 安井孝周、岡田淳志、濱本周造、郡健二郎
  • Journal Title: 現代医学 Volume: 60 Pages: 53-61
• [Journal Article] 宇宙飛行・長期臥床と尿路結石 (2012)
  • Author(s): 郡健二郎、安井孝周、岡田淳志
  • Journal Title: CLINICAL CALCIUM Volume: 19 Pages: 1821-1828
• [Journal Article] 診療に活用できる尿路結石症の疫学 (2012)
  • Author(s): 安井孝周、安藤亮介、岡田淳志、戸澤啓一、井口正典、郡健二郎
  • Journal Title: 泌尿紀要 Volume: 58 Pages: 697-701
• [Presentation] A paracrine mechanism promotes kidney stone formation in a simulated metabolic syndrome environment using in vitro and in vivo studies. (2014)
  • Author(s): Okada Atsushi, Yasui Takahiro, Zou Li, Unno Rei, Fujii Yasuhiro, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Itoh Yasunori, Tozawa Keiichi, Sasaki Shoichi, Rodgers Allen, Kohri Kenjiro
  • Organizer: 2nd of Experts in Stone Disease (ESD)
  • Place of Presentation: Cape Town（South Africa）
  • Year and Date: 2014-12-10 – 2014-12-13
• [Presentation] ロボット支援腹腔鏡手術創の疼痛・満足度に関わる因子 (2014)
  • Author(s): 岡田 淳志、黒川 覚史、水野 健太郎、安井 孝周、梅本 幸裕、河合 憲康、戸澤 啓一、佐々木 昌一、林 祐太郎、郡 健二郎
  • Organizer: 第28回日本泌尿器内視鏡学会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県福岡市）
  • Year and Date: 2014-11-26 – 2014-11-28
• [Presentation] Possible new urine markers for calcium oxalate “stone formers”: macrophage-related cytokines/chemokines detected by multiplex analysis. (2014)
  • Author(s): Okada Atsushi, Yasui Takahiro, Taguchi Kazumi, Fujii Yasuhiro, Niimi Kazuhiro, Hamamoto Shuzo, Hirose Masahito, Ando Ryosuke, Kubota Yasue, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2014
  • Place of Presentation: Orlando（USA）
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] マルチプレックス解析を用いた尿路結石患者に特異的な尿中マクロファージ関連因子の同定 (2014)
  • Author(s): 岡田 淳志、田口 和己、藤井 泰普、新美 和寛、濵本 周造、安井 孝周、広瀬 真仁、戸澤 啓一、郡 健二郎
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] 2.尿路結石の再発予防（2）薬物療法。 (2014)
  • Author(s): 岡田 淳志
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-04-24 – 2014-04-27
  • Invited
• [Presentation] 90g以上の大きな前立腺に対するロボット支援下前立腺全摘除術の経験 (2013)
  • Author(s): 安井孝周、戸澤啓一、黒川覚史、濱川隆、藤井泰普、新美和寛、廣瀬泰彦、岩月正一郎、井村誠、岡田淳志、水野健太郎、窪田泰江、梅本幸裕、河合憲康、佐々木 昌一、林祐太郎、小島祥敬、郡健二郎
  • Organizer: 第5回日本ロボット外科学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2013-01-19
• [Presentation] 腎結石の溶解療法の開発に向けたマクロファージによるシュウ酸カルシウム結晶の貪食機序の解明。 (2013)
  • Author(s): 岡田 淳志、安井 孝周、田口 和己、藤井 泰普、濵本 周造、伊藤 恭典、戸澤 啓一、郡 健二郎
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: さっぽろ芸術文化の館（札幌）
• [Presentation] R2-U1結石に対するESWL成功率における超音波照準の有用性 (2013)
  • Author(s): 岡田 淳志、飯田 啓太郎、田口 和己、藤井 泰普、岩月 正一郎、内木 拓、井村 誠、神沢 英幸、広瀬 真仁、梅本 幸裕、河合 憲康、佐々木 昌一、郡 健二郎
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: さっぽろ芸術文化の館（札幌）
• [Presentation] Effect of an ultrasonic targeting method for kidney and proximal ureter stones on the success rate of shock wave lithotripsy. (2013)
  • Author(s): Okada Atsushi, Taguchi Kazumi, Ando Ryosuke, Umemoto Yukihiro, Itoh Yasunori, Yasui Takahiro, Sasaki Shoichi, Kohri Kenjiro, Hamamoto Shuzo
  • Organizer: American Urological Association Annual Meeting 2013
  • Place of Presentation: San Diego Convention Center( San Diego, USA)
• [Presentation] Active phagocytosis and processing of calcium oxalate monohydrate crystals in an in vitro macrophage model. (2013)
  • Author(s): Okada Atsushi, Yasui Takahiro, Zuo Li, Taguchi Kazumi, Fujii Yasuhiro, Itoh Yasunori, Hirose Yasuhiko, Uasami Masayuki, Niimi Kazuhiro, Ando Ryosuke, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasuhiko, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: European Association of Urology Annual Meeting 2013
  • Place of Presentation: Milan(Italy)
• [Presentation] 腎細胞癌術後21年目に骨格筋・皮膚転移をきたした1例 (2012)
  • Author(s): 廣瀬泰彦、惠谷俊紀、濱川隆、田口和己、安藤亮介、岡田淳志、安井孝周、河合憲康、戸澤啓一、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第258回日本泌尿器科学会東海地方会
  • Place of Presentation: 中外東京海上ビルディング(愛知県)
  • Year and Date: 2012-12-09
• [Presentation] 腎結石の自然消失に係わる抗炎症性マクロファージ (M2) の作用機序の解明 (2012)
  • Author(s): 田口和己、岡田淳志、安井孝周、戸澤啓一、北村浩、三好一郎、郡健二郎
  • Organizer: 第63回名古屋市立大学医学会総会
  • Place of Presentation: 名古屋市立大学(愛知県)
  • Year and Date: 2012-12-02
• [Presentation] 腎・膀胱Neuroendocrinecarcinomaの1例 (2012)
  • Author(s): 岡田淳志、西尾英紀、濱川隆、新美和寛、井村誠、神沢英幸、水野健太郎、安井孝周、戸澤啓一、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第257回日本泌尿器科学会東海地方会
  • Place of Presentation: 中外東京海上ビルディング(愛知県)
  • Year and Date: 2012-09-08
• [Presentation] 透析患者の両側腎癌を契機に診断したBirt-Hogg-Dube症候群の1例 (2012)
  • Author(s): 神沢英幸、岡田淳志、惠谷俊紀、濱川隆、新美和寛、水野健太郎、窪田泰江、安井孝周、戸澤啓一、林祐太郎、郡健二郎
  • Organizer: 第256回日本泌尿器科学会東海地方会
  • Place of Presentation: 中外東京海上ビルディング(愛知県)
  • Year and Date: 2012-06-09
• [Presentation] マクロファージは腎結石形成過程においてシュウ酸カルシウム結晶を貧食する (2012)
  • Author(s): 岡田淳志、安井孝周、田口和己、新美和寛、藤井泰普、廣瀬泰彦、宇佐美雅之、小林隆宏、濱本周造、広瀬真仁、伊藤恭典、戸澤啓一、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] ゲノムワイド解析によるメタボリックシンドローム環境下の腎結石関連遺伝子の同定と機能解析 (2012)
  • Author(s): 藤井泰普、岡田淳志、安井孝周、廣瀬泰彦、浜本周造、安藤亮介、広瀬真仁、伊藤恭典、戸澤啓一、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 腎結石に対する治療法の工夫-小径腎盂鏡を用いたTUL併用細経PNLシステムの確立- (2012)
  • Author(s): 濱本周造、安井孝周、岡田淳志、岩月正一郎、田口和己、藤井泰普、河合憲康、戸澤啓一、藤田圭治、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] PNLにおける修正Valdivia体位の有効性についての検討 (2012)
  • Author(s): 広瀬真仁、成山泰道、福田勝洋、荳田淳志、窪田裕樹、伊藤恭典、安井孝周、山田泰之、戸澤啓一、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] メラミンによる結石形成と腎機能障害発生における雌雄差、週齢差の検討 (2012)
  • Author(s): 小林隆宏、新美和寛、伊藤恭典、田口和己、藤井泰普、濱本周造、広瀬真仁、岡田淳志、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] シロドシン投与により下部尿管結石の排石期間は短縮し排石した結石サイズは増加した (2012)
  • Author(s): 伊藤恭典、田口和己、新美和寛、藤井泰普、廣瀬泰彦、宇佐美雅之、小林隆宏、濱本周造、広瀬真仁、岡田淳志、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 腹腔鏡下尿管切石術の適応と有用性について-上部尿路結石の手術治療アルゴリズムの提案 (2012)
  • Author(s): 安井孝周、岡田淳志、戸澤啓一、濱本周造、小島祥敬、梅本幸裕、河合憲康、窪田裕樹、山田泰之、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 尿路結石の初期形成におけるMitochondrial Permeability Transition Pore開口の作用機序とその予防法の確立 (2012)
  • Author(s): 新美和寛、安井孝周、市川潤、田口和己、藤井泰普、廣瀬泰彦、小林隆宏、浜本周造、広瀬真仁、岡田淳志、伊藤恭典、戸澤啓一、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 小径腎癌に対する単孔式無阻血腹腔鏡下腎部分切除術の開発 (2012)
  • Author(s): 河合憲康、小島祥敬、安井孝周、内木拓、岡田淳志、水野健太郎、窪田泰江、戸澤啓一、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] Renal macrophages could englobe calcium oxalate crystals during kidney stone formation in vitro and in vivo models. (2012)
  • Author(s): Okada Atsushi. Yasui Takahiro, Taguchi Kzaumi, Hirose Yasuhiko, Niimi Kazuhiro, Fujii Yasuhiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Crystal Kinetics and Processing in Human Kidney Stone Formation: Comparison of Clinical and Pathological Findings in Stone Formers and Non-Stone Formers. (2012)
  • Author(s): Okada Atsushi. Yasui Takahiro, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Hamamoto Shuzo, Hirose Masahito, Itho Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Efficacy of Dornier official technical training for SWL treatment at the university hospital. (2012)
  • Author(s): Okada Atsushi. Yasui Takahiro, Taguchi Kazumi, Fujii Yasuhiro, Hamamoto Shuzo, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] The role of Jaridla in spermatogenesis : Evaluation of transcriptional regulation by histone H3K4 methylation. (2012)
  • Author(s): Nishio Hidenori, Kojima Yoshiyuki, Moritoki Yoshinobu, Imura Makoto, Kamisawa Hideyuki, Okada Atsushi. Mizno Kentaro, Umemoto Yukihiro, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Gene expression profiling and functional network analysis of benign prostatic hyperplasia model rat. (2012)
  • Author(s): Kojima Yoshiyuki, Sasaki Shoichi, Imura Makoto, Mizuno Kentaro, Okada Atsushi. Kubota Yasue, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Regulation of cell proliferation through a KIT-mediated mechanism. (2012)
  • Author(s): Imura Makoto, Kojima Yoshiyuki, Hamakawa Takashi, Okada Atsushi, Kubota Yasue, Umemoto Yukihiro, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] The histological reaction of foreskin after testosterone treatment prior to hypospadias surgery. (2012)
  • Author(s): Nihio Hidenori, Mizuno Kentaro, Moritoki Yoshinobu, Imura Makoto, Kamisawa Hideyuki, Okada Atsushi, Umemoto Yukihiro, Ko!jima Yoshiyuki, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Macrophage-colony stimulating factor (M-CSF) is a novel preventive agent against renal stone disease by inducing anti-inflammatory macrophages. (2012)
  • Author(s): Tagushi Kazumi, Okada Atsushi, Fujii Yasuhiro, Niimi Kazuhiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Administration of the selective alpha 1A adrenoceptor antagonist silodosin facilitates expulsion of 1.5mm or larger distal ureteral stones, as compared to control. (2012)
  • Author(s): Itho Yasunori, Okada Atsushi, Hirose Masahito, Kobayashi Takahiro, Niimi Kazuhiro, Kojima Yoshiyuki, Kubota Yasue, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] A specific antibody against thrombin-cleaved osteopontin contributes to inhibition of renal crystal formation in mice. (2012)
  • Author(s): Hamamoto Shuzo, Yasui Takahiro, Okada Atsushi, Niimi Kazuhiro, Taguchi Kazumi, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] The role of long-term loading of cholesterol in renal crystal formation. (2012)
  • Author(s): Fujii Yasuhiro, Okada Atsushi, Taguchi Kazumi, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Kojima Yoshiyuki, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] Bisphosphonate prevents urolithiasis in men with osteoporosis by reducing the urinary ion activity product of calcium stone. (2012)
  • Author(s): Yasui Takahiro, Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, An do Ryosuke, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Kubota Yasue, et al.
  • Organizer: American Urological Association Annual Meeting 2012
  • Place of Presentation: Atlanta(USA)
• [Presentation] 健診受診者における腎結石患者と慢性腎臓病・心血管疾患のリスク要因との関連 (2012)
  • Author(s): 安藤亮介、永谷照男、鈴木貞夫、高橋英勝、河合信、岡田淳志、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 第21回日本腎泌尿器疾患予防医学研究会
  • Place of Presentation: ホテル日航高知、高知市文化プラザ(高知県)
• [Presentation] 腹臥位による巨大な腎結石に対するTULとPNLの同時治療法の開発-3D-CT画像による腹臥位治療の有用性の検討- (2012)
  • Author(s): 濱本周造、田口和己、新美和寛、藤井泰普、廣瀬泰彦、岡田淳志、安井孝周、藤田圭治、戸澤啓一、岩瀬豊、郡健二郎
  • Organizer: 日本尿路結石症学会第22回学術集会
  • Place of Presentation: アクトシティ浜松コングレスセンター(静岡県)
• [Presentation] 腎結石と慢性腎臓病・心血管疾患リスクに関する臨床疫学研究 (2012)
  • Author(s): 安藤亮介、永谷照男、鈴木貞夫、高橋英勝、河合信、岡田淳志、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 日本尿路結石症学会第22回学術集会
  • Place of Presentation: アクトシティ浜松コングレスセンター(静岡県)
• [Presentation] M-CSFによる抗炎症性マクロファージ (M2) の活性は結石を防御する (2012)
  • Author(s): 田口和己、岡田淳志、伊藤靖彦、廣瀬泰彦、藤井泰普、新美和寛、宇佐美雅之、小林隆宏、演本周造、広瀬真仁、伊藤恭典、安井孝周、戸澤啓一、郡健二郎
  • Organizer: 日本尿路結石症学会第22回学術集会
  • Place of Presentation: アクトシティ浜松コングレスセンター(静岡県)
• [Presentation] 尿路結石の初期形成に係わるミトコンドリア崩壊のメカニズムと治療への応用-分子標的治療薬NIM811の開発- (2012)
  • Author(s): 新美和寛、安井孝周、田口和己、藤井泰普、廣瀬泰彦、小林隆宏、濱本周造、広瀬真仁、岡田淳志、伊藤恭典、戸澤啓一、郡健二郎
  • Organizer: 日本尿路結石症学会第22回学術集会
  • Place of Presentation: アクトシティ浜松コングレスセンター(静岡県)
• [Presentation] Development of a simple method for preventing inguinal hernias after laparoscopic prostatectomy. (2012)
  • Author(s): Yasui Takahiro, Okada Atsushi, Mizuno Kentaro, Umemoto Yukihiro, Kawai Noriyasu, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: 30th World Congress of Endourology and SWL
  • Place of Presentation: Istanbul (Turkey)
• [Presentation] Laparoscopic adrenalectomy for solitary metastatic adrenal tumor of lung cancer origin. (2012)
  • Author(s): Kawai Noriyasu, Naiki Taku, Etani Toshiki, Nagata Daisuke, Mizuno Kentaro, Okada Atsushi, Umemoto Yukihiro, Yasui Takahiro, Akita Hidetoshi, Kojima Yoshiyuki, Okamura Takehiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: 30th World Congress of Endourology and SWL
  • Place of Presentation: Istanbul (Turkey)
• [Presentation] What influences operation time for laparoscopic nephrectomy? (2012)
  • Author(s): Umemoto Yukihiro, Tozawa Keiichi, Kojima Yoshiyuki, Yasui Takahiro, Kawai Noriyasu, Mizuno Kentaro, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: 30th World Congress of Endourology and SWL
  • Place of Presentation: Istanbul (Turkey)
• [Presentation] The role of renal tubular cell injury in the early period of renal crystal formation : Identified from the cell injury-inhibiting effect of green tea. (2012)
  • Author(s): Hirose Masahito, Hamamoto Shuzo, Naruyama Hiromichi, Fukuda Katsuhiro, Okada Atsushi, Kubota Hiroki, Yasui Takahiro, Yamada Yasuyuki, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Antigen-specific induction of thrombin-cleaved form of osteopontin contributes to inhibit renal stone formation. (2012)
  • Author(s): Hamamoto Shuzo, Yasui Takahiro, Okada Atsushi, Niimi Kazuhiro, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Macrophage-colony stimulating factor (m-csf) is a novel preventive agent againstrenal stone disease by inducing anti-inflammatory macrophages. (2012)
  • Author(s): Taguchi Kazumi, Okada Atsushi, Fujii Yasuhiro, Niimi Kazuhiro, Hamamoto Shuzo, Hirose Masahito, Yasui Takahiro, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Adiponectin ameliorates kidney stone formation in metabolic syndrome model mice. (2012)
  • Author(s): Fujii Yasuhiro, Okada Atsushi, Kobayashi Takahiro, Usami Masayuki, Hamamoto Shuzo, Hirose Masahiro, Yasui Takahiro, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Association between nephrolithiasis incidence and nutrition based on data from a japanese national survey. (2012)
  • Author(s): Yasui Takahiro, Okada Atsushi, Niimi Kazuhiro, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Iguchi Masanori, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Bisphosphonate has a preventive effect on the recurrence of nephrolithiasis in men. (2012)
  • Author(s): Yasui Takahiro, Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Usami Masayuki, Ando Ryosuke, Hamamoto Shuzo, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Elucidation of metabolic syndrome-related paracrine system by co-culturing renaltubular epithelial cells and adipocytes. (2012)
  • Author(s): Fujii Yasuhiro, Okada Atsushi, Ichikawa Jun, Taguchi Kazumi, Hirose Yasuhiko, Hamamoto Shuzo, Yasui Takahiro, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Prevention mechanism of green tea on renal stone formation. (2012)
  • Author(s): Niimi Kazuhiro, Yasui Takahiro, Hirose Yasuhiko, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Okada Atsushi, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Activation of cyclophilin D induces the initial process of kidney stone formation via mitochondrial permeability transition pore opening. (2012)
  • Author(s): Niimi Kazuhiro, Yasui Takahiro, Hirose Masahito, Okada Atsushi, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Pioglitazone : A peroxisome proliferator-activated receptor gamma agonist, prevents kidney stone formation via antioxidative and anti-inflammatory effects. (2012)
  • Author(s): Taguchi Kazumi, Okada Atsushi, Kobayashi Takahiro, Hamamoto Shuzo, Ando Ryosuke, Hirose Masahito, Yasui Takahiro, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Development of endoscopic hybrid therapy for renal calculi using the prone split-leg position : simultaneous use of flexible ureteroscopy and mini-percutaneous nephrolithotomy. (2012)
  • Author(s): Hamamoto Shuzo, Yasui Takahiro, Okada Atsushi, Niimi Kazuhiro, Taguchi Kazumi, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Benefits of the modified valdivia position in PNL. (2012)
  • Author(s): Hirose Masahito, Naruyama Hiromichi, Fukuta Katsuhiro, Hamamoto Shuzo, Okada Atsushi, Kubota Hiroki, Yasui Takahiro, Yamada Yasuyuki, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 第32回国際泌尿器科学会(SIU)
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] 水分摂取からメタボリックシンドローム、そして宇宙空間での予防へ (2012)
  • Author(s): 岡田淳志
  • Organizer: 第62回日本泌尿器科学会中部総会
  • Place of Presentation: 富山国際会議場(富山県)(招待講演)
• [Presentation] ESWL技術トレーニングは砕石効率を高める (2012)
  • Author(s): 岡田淳志、安井孝周、田口和己、藤井泰普、新美和寛、河合憲康、戸澤啓一、林祐太郎、郡健二郎
  • Organizer: 第62回日本泌尿器科学会中部総会
  • Place of Presentation: 富山国際会議場(富山県)
• [Presentation] ロボット支援下前立腺全摘除術104例の検討 (2012)
  • Author(s): 安井孝周、戸澤啓一、岡田淳志、水野健太郎、窪田泰江、梅本幸裕、河合憲康、佐々木昌一、林祐太郎、郡健二郎、黒川覚史、小島祥敬
  • Organizer: 第62回日本泌尿器科学会中部総会
  • Place of Presentation: 富山国際会議場(富山県)
• [Presentation] ロボット支援下前立腺全摘除術の術後尿失禁の評価 (2012)
  • Author(s): 井村誠、安井孝周、濱川隆、新美和寛、岡田淳志、窪田泰江、梅本幸裕、戸澤啓一、佐々木昌一、林祐太郎、郡健二郎、小島祥敬、黒川覚史
  • Organizer: 第62回日本泌尿器科学会中部総会
  • Place of Presentation: 富山国際会議場(富山県)
• [Presentation] 2-U1結石に対する超音波を併用した照準のESWL成功率への効果 (2012)
  • Author(s): 岡田淳志、安井孝周、新美和寛、梅本幸裕、窪田泰江、河合憲康、戸澤啓一、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第26回日本泌尿器内視鏡学会総会
  • Place of Presentation: 仙台国際センター(宮城県)
• [Presentation] 肺多型癌の孤立性副腎転移に対する腹腔鏡下副腎摘除術 (2012)
  • Author(s): 河合憲康、内木拓、水野健太郎、岡田淳志、梅本幸裕、安井孝周、戸澤啓一、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第26回日本泌尿器内視鏡学会総会
  • Place of Presentation: 仙台国際センター(宮城県)
• [Presentation] 腹腔鏡下根治的腎摘除術における手術時間の規定因子の検討 (2012)
  • Author(s): 梅本幸裕、戸澤啓一、安井孝周、河合憲康、水野健太郎、岡田淳志、小島祥敬、佐々木昌一、林祐太郎、郡健二郎
  • Organizer: 第26回日本泌尿器内視鏡学会総会
  • Place of Presentation: 仙台国際センター(宮城県)