The elucidation of the effect of T-cell and mechanism of metabolic syndrome by dietary composition
Project/Area Number |
24700828
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Eating habits, studies on eating habits
|
Research Institution | The University of Tokushima |
Principal Investigator |
SHUTO Emi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (10512121)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | メタボリックシンドローム / 大豆イソフラボン / 慢性炎症 / 栄養免疫 |
Research Abstract |
Metabolic syndrome is the underlying disease proceed crirical disorder, diabetes, stroke, et al. Nearly, it was reported that T cell-infiltrated in adipose tissues was regulated differentiation of macrophage, so macrophage was dictated chronic inflammation in adipose tissue and whole-body. We ever reported about immune function of soy isoflavone. In this study, we examined effect of Soy isoflavones on the inflammation in diet indused obesity mice. Soy isoflavones were ameliorated glucose metabolism and lipid metabolism, and declining trend to accumulation of body fat. In particular, Equol was significantly inhibited expression of gene associated macrophage. Thus, it is suggested that soy isoflavone might be possible to prevent metabolic syndrome.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Period between Dinner and Bedtime Is Related to Hypertension2013
Author(s)
Nakamoto M, Sakai T, Shuto E, Aki N, Kosugi C, Hata A, Shinoda K, Kuwamura Y, Minagawa T, Ichihara T, Tamura A, Funaki M
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Journal Title
J Jpn Soc Nutr Food Sci
Volume: 66
Pages: 185-193
Related Report
Peer Reviewed
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[Journal Article] Period between Dinner and Bedtime Is Related toHypertension2013
Author(s)
Nakamoto M, Sakai T, Shuto E, Aki N, Kosugi C, Hata A, Shinoda K, Kuwamura Y, Minagawa T, Ichihara T, Tamura A, Funaki M
-
Journal Title
J Jpn Soc Nutr Food Sci.
Volume: 66
Pages: 185-193
Related Report
Peer Reviewed
-
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