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The effect of dietary beta-carotene on glucose intolerance in the iron-deficient GK rats.

Research Project

Project/Area Number 24700850
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionJin-ai University

Principal Investigator

IKEDA RYOUKO  仁愛大学, 人間生活学部, 准教授 (80352805)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords鉄欠乏性貧血 / 耐糖能異常 / β-カロテン / 酸化ストレス / 生体内相互作用 / 鉄欠乏 / βカロテン / 基礎栄養学
Outline of Final Research Achievements

Increase of blood sugar and inflammatory cytokine was observed in the iron-deficient GK rats, model animal of type 2 diabetes mellitus. It was supposed that these phenomena were caused by the lipid peroxidation in the iron-deficiency. In this study, we examined the effect of dietary β-carotene on suppression of inflammatory cytokine and improvement of the glucose tolerance in the iron-deficient GK rats.
In the first experiment, serum adiponectin increased, and in the second experiment, serum resistin was decreased by dietary β-carotene administration. However, it was very difficult to confirm plasticity about the alteration of these adipocytokine. These results suggested that the change of beta-carotene dose participated in serum insulin-resistant factor complicatedly. To inflammatory cytokine and blood sugar, the effect of dietary β-carotene was not observed, and it was guessed that a factor except peoxidation derived impaired glucose tolerance in the iron-deficient GK rats.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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