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Radiobiological effect induced by laser-plasma soft x-ray microbeam

Research Project

Project/Area Number 24710096
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Quantum beam science
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

NISHIKINO Masaharu  独立行政法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (70370450)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsレーザープラズマX線 / 軟X線レーザー / 放射線生物影響 / マイクロビーム / レーザープラズマX線 / フレネルゾーンプレート
Research Abstract

Techniques for generating high energy bright short-pulse x-rays have been developed with utilizing intense ultrashort laser pulses. X-ray focusing optics has enabled focused x-ray beams of micron spot size in soft x-ray regions. The short duration of laser produced plasma source could be a new source in contrast to conventional x-ray sources in investigating the mechanism of the radiation effect on biological cells. We investigated whether the soft X-ray laser induces the DNA double strand breaks (DSB) and single strand breaks (SSB) in living cell or not. The appearance of DSB induced by soft X-ray laser was significantly different in that induced by a conventional high energy X-ray source. We also demonstrated an efficient extreme ultraviolet source for an X-ray microscopy technique, and developed a grazing angle incident reflection type soft-X-ray microscope using a Fresnel zone plate.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results) (of which Invited: 2 results)

  • [Journal Article] Development of Soft X-Ray Microscopy Using Fresnel Zone Plate for Observation of Laser-Induced Surface Dynamics2013

    • Author(s)
      M. Nishikino et al.(他7名)
    • Journal Title

      Springer Proceedings in Physics (X-Ray Lasers 2012)

      Volume: Vol. 147

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique2013

    • Author(s)
      M. Nishikino et al.(他12名)
    • Journal Title

      Proceedings of SPIE

      Volume: vol. 8849

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique2013

    • Author(s)
      M. Nishikino et al.
    • Journal Title

      Proceedings of SPIE

      Volume: 8849

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Soft-XRay Microscopy Using Fresnel Zone Plate for Observation of Laser-Induced Surface Dynamics2013

    • Author(s)
      M. Nishikino et al.
    • Journal Title

      Springer Proceedings in Physics (X-Ray Lasers 2012)

      Volume: 147 Pages: 199-202

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of soft x-ray microscopy using Fresnel zone plate for observation of laser-induced surface dynamics2013

    • Author(s)
      Masaharu Nishikino
    • Journal Title

      AIP Conference Proceedings

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Observation of the surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique2013

    • Author(s)
      Masaharu Nishikino
    • Organizer
      The Eighth International Conference on Inertical Fusion Sciences and Applications
    • Place of Presentation
      奈良県立公会堂(奈良)
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique2013

    • Author(s)
      M. Nishikino
    • Organizer
      SPIE Optics+Photonics (X-Ray Lasers and Coherent X-Ray Sources; Development and Applications X)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] プラズマX線レーザーの発生と物質アプレーション2012

    • Author(s)
      錦野将元
    • Organizer
      2012年応用物理学会秋期学術講演会
    • Place of Presentation
      愛媛大学(愛媛)
    • Year and Date
      2012-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of soft x-ray microscopy using Fresnel zone plate for ibservation of laser-induced surface dynamics2012

    • Author(s)
      Masaharu Nishikino
    • Organizer
      International conference on X-ray lasers 2012
    • Place of Presentation
      Historical Center of Cordeliers, Paris, France
    • Year and Date
      2012-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique

    • Author(s)
      M. Nishikino et al.
    • Organizer
      SPIE Optics+Photonics(X-Ray Lasers and Coherent X-Ray Sources: Development and Applications X)
    • Place of Presentation
      San Diego(米国)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Observation of the surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique

    • Author(s)
      M. Nishikino et al.
    • Organizer
      The Eighth International Conference on Inertial Fusion Sciences and Applications
    • Place of Presentation
      奈良県立新公会堂(奈良)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of soft x-ray microscopy using Fresnel zone plate for observation of laser-induced surface dynamics

    • Author(s)
      Masaharu Nishikino
    • Organizer
      International conference on X-ray lasers 2012
    • Place of Presentation
      Historical Center of Cordeliers(フランス・パリ)
    • Related Report
      2012 Research-status Report
  • [Presentation] プラズマX線レーザーの発生と物質アブレーション

    • Author(s)
      錦野将元
    • Organizer
      2012年応用物理学会秋季学術講演会
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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