Radiobiological effect induced by laser-plasma soft x-ray microbeam
| Project/Area Number |
24710096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Quantum beam science
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
NISHIKINO Masaharu 独立行政法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (70370450)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | レーザープラズマＸ線 / 軟Ｘ線レーザー / 放射線生物影響 / マイクロビーム / レーザープラズマX線 / フレネルゾーンプレート |
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| Research Abstract |
Techniques for generating high energy bright short-pulse x-rays have been developed with utilizing intense ultrashort laser pulses. X-ray focusing optics has enabled focused x-ray beams of micron spot size in soft x-ray regions. The short duration of laser produced plasma source could be a new source in contrast to conventional x-ray sources in investigating the mechanism of the radiation effect on biological cells. We investigated whether the soft X-ray laser induces the DNA double strand breaks (DSB) and single strand breaks (SSB) in living cell or not. The appearance of DSB induced by soft X-ray laser was significantly different in that induced by a conventional high energy X-ray source. We also demonstrated an efficient extreme ultraviolet source for an X-ray microscopy technique, and developed a grazing angle incident reflection type soft-X-ray microscope using a Fresnel zone plate.
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Report
(3 results)
Research Products
(13 results)
