New behavioral animal model to study vulnerability factors for depression
| Project/Area Number |
24730636
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
DOE Nobutaka 兵庫医科大学, 医学部, 非常勤講師 (00434879)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | うつ病 / 動物モデル / 水迷路学習 / マウス / 行動的絶望 / 発症脆弱性 / 個体差 / 神経細胞新生 / サイトカイン |
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| Research Abstract |
We have developed a new animal model of depression by modifying the water maze learning task in mice. When the difficulty of the task is increased, some of the mice gradually cease to swim and become immobile; this response indicates a helpless state. In this research, we investigated a critical mechanism underlying depression-like phenotypes of the helpless mice. Escape failures at early stage of training increased occurrence of the helpless mice. However, occasional successful escape during the training phase enhanced immobility and cognitive impairments in subsequent learning task. On the other hand, repeated administration of fluvoxamine for 24 days caused a significant increase in the number of BrdU-positive cells in the dentate gyrus of the helpless mice, an effect which was paralleled by a behavioral improvement. This result suggests that the reduction of hippocampal neurogenesis is associated with robust and consistent behavioral abnormalities in the helpless mice.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] A DKP Cyclo(L-Phe-L-Phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterase2012
Author(s)
Tsuruoka, N., Beppu, Y., Koda, H., Doe, N., Watanabe, H., Abe, K
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Journal Title
Plos One
Volume: 7(11)
Issue: 11
Pages: 1-10
DOI
Related Report
Peer Reviewed
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[Presentation] Molecular analysis of prefrontal cortex in mice exposed to chronic mild stress; the influence on homeostasis in depressive state2013
Author(s)
Yamanishi, K., Doe, N., Yamamoto, H., Xu, Y., Li, W., Sumida, M., Yamanishi, H., Okamura, H., & Matsunaga, H
Organizer
18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine
Place of Presentation
Crete, Greece
Related Report
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[Presentation] Gene expression profiling of prefrontal cortex comparing in mice behavioral despair after a water maze learning task and Chronic Mild Stress2013
Author(s)
Yamanishi, K., Doe, N., Yamamoto, H., Xu, Y., Li, W., Kiriyama, M., Yamanishi, H., Okamura, H., & Matsunaga, H
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto
Related Report
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[Presentation] Gene expression profiling of prefrontal cortex comparing in mice behavioral despair after a water maze learning task and Chronic Mild Stress.2013
Author(s)
Yamanishi, K., Doe, N., Yamamoto, H., Xu, Y., Li, W., Kiriyama, M., Yamanishi, H., Okamura, H., & Matsunaga, H.
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] Molecular analysis of prefrontal cortex in mice exposed to chronic mild stress; the influence on homeostasis in depressive state.2013
Author(s)
Yamanishi, K., Doe, N., Yamamoto, H., Xu, Y., Li, W., Sumida, M., Yamanishi, H., Okamura, H., & Matsunaga, H.
Organizer
18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine
Place of Presentation
Crete, Greece
Related Report
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