| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
To reveal the mechanism of the anterior-posterior (A-P) axis formation in a mouse embryo, the expression pattern of head organizer genes have been reexamined. I found that OTX2 gene was asymmetrically expressed from the very beginning of their expression. The gene which makes Otx2 express asymmetrically might have an important role to develop A-P axis. I also established a culture system of mouse embryos for live-imaging experiments. Then, the behavior of each embryonic visceral endoderm cell during the A-P axis formation has been examined by live-imaging experiments. I found some characteristic cell behaviors which remained to be reported.
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