Evaluation for the prognostic index of SIRS and a target for blood purification therapy in dogs

Research Project

Project/Area Number	24780310
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Clinical veterinary science
Research Institution	Yamaguchi University (2013) Kagoshima University (2012)
Principal Investigator	SHIMOKAWA Takako 山口大学, 獣医学部, 助教 (50594404)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	SIRS / プロカルシトニン / HMGB1 / 敗血症
Research Abstract	To investigate the possibility of procalcitonin as a prognostic index of SIRS and a target for blood purification therapy in dogs, a measuring system for canine procalcitonin using ELISA has been established. A recombinant canine procalcitonin protein and polyclonal antibodies were obtained by cloning canine procalcitonin gene cDNA. These antibodies specifically recognized canine procalcitonin and was able to detect canine procalcitonin by ELISA.