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Construction of oligosaccharide library with one-pot fluorous method

Research Project

Project/Area Number 24790034
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionThe Noguchi Institute

Principal Investigator

GOTO Kohtaro  公益財団法人野口研究所, 研究部, 研究員 (30321673)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords糖鎖合成 / フルオラス / One-Potグリコシル化
Research Abstract

Conventional furuorous method could not be separated fluorous by-products from the fluorous media. It currently has no methods to remove these fluorous by-products efficiently, and is one of the most potentially problematic issues in the fluorous tagging method. Especially, this task is so serious in oligosaccharides synthesis, because the yield of glycosylation, which is a key reaction in oligosaccharides synthesis, isn't necessary good. In order to overcome this problem, we attempted a development of one-pot fluorous method which was combined with the conventional fluorous method and one-pot glycosylation method. As a result, we found that the fluorous by-products which were introduced a fluorous tag having two perfluorooctyl chains every one sugar residue could be removed into organic layer by a simple partitioning between fluorous solvent and organic solvent.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2013 2012

All Presentation (4 results)

  • [Presentation] STUDY OF PARTITION COEFFICIENTS OF FLUOROUS CARBOHYDRATE SYNTHESIS2013

    • Author(s)
      K. Goto, M. Mizuno
    • Organizer
      International Symposium on Fluorous Technologies
    • Place of Presentation
      Budapest Hungary
    • Related Report
      2013 Final Research Report
  • [Presentation] STUDY OF PARTITION COEFFICIENTS OF FLUOROUS CARBOHYDRATE SYNTHESIS2013

    • Author(s)
      K. Goto and M. Mizuno
    • Organizer
      International Symposium on Fluorous Technologies
    • Place of Presentation
      ブダペスト (ハンガリー)
    • Related Report
      2013 Annual Research Report
  • [Presentation] フルオラスOne-Potグリコシル化法の開発2012

    • Author(s)
      後藤浩太朗、弘瀬友理子、水野真盛
    • Organizer
      フルオラス科学研究会第5回シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-29
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] CARBOHYDRATE SYNTHESIS USING FLUOROUS CHEMISTRY2012

    • Author(s)
      M. Mizuno, K. Goto, H. Kawakami, M. Tojino
    • Organizer
      The 26th International Carbohydrate Symposium (ICS2012)
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Final Research Report 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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