Relationship between diabetes and epigenetic modification regulated by ketone body metabolism

Research Project

Project/Area Number	24790244
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	The University of Tokushima
Principal Investigator	UEBANSO Takashi 徳島大学, ヘルスバイオサイエンス研究部, 助教 (10581829)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	糖尿病 / エピゲノム / ケトン体 / 栄養学 / 代謝の流れ
Research Abstract	I studied relationship between deiabetes and epigenome modification regulated by ketone body metabolism. Knock down of one of two enzyme which metabolise ketone body affect methylation of histone H3. Moreover, disruption of ketone body metabolism affect stress induced cytotoxicity in pancreatic beta cells. These results suggest that ketone body metabolism link epigenenome modification and cellular function.