Development of a new method to induce cardiomyocytes from pluripotent stem cells in vivo for regenerative cell therapy.
| Project/Area Number |
24790277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 再生医学 / iPS細胞 / 再生医療 / 心筋細胞 / 多能性幹細胞 |
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| Research Abstract |
We compared the grafting efficiency of undifferentiated cell, early mesodermal cells, cardiomyocytes (early- and middle-stage) from human iPS cells in transplantation into mouse hearts, and found that middle-stage differentiated cardiomyocytes can be grafted efficiently. We also observed that transplanted differentiated cardiomyocytes can survive and maturate in the infarcted mouse hearts and improve the cardiac function.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.2014
Author(s)
Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, YamanakaS.
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Journal Title
Scientific Reports
Volume: 4
Issue: 1
Pages: 3594-3594
DOI
NAID
Related Report
Peer Reviewed
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