| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Angiogenesis is an essential event for animal development. Beta-catenin is a well-known molecule for regulating angiogenesis. Lack of beta-catenin in blood vessel cells cause vascular abnormality and poor development in mouse. However when and where beta-catenin is activated is not well known. To understand and visualize beta-catenin activity, we generated transgenic zebrafish which represents beta-catenin transcriptional activity in living fish.
By using the fish, we identified that beta-catenin activated cells during caudal vein plexuses formation. Furthermore, the activity of beta-catenin is positively regulated by Bone Morphogenetic Protein (BMP) dependent AnGiogenic factor with G patch and FHA domains 1 (AGGF1) expression. The activation of beta-catenin in CVP is dispensable for cell survival and cell differentiation.
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