Estrogens in male breast carcinoma
| Project/Area Number |
24790343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKAGI Kiyoshi 東北大学, 医学(系)研究科(研究院), 助教 (80595562)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 男子乳癌 / エストロゲン |
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| Research Abstract |
We examined intratumoral estrogen concentrayion, estrogen receptor and its responsive genes in male breast carcinomas in order to clarify estrogen action in male breast carcinomas.
Tissue estradiol level was markedly higher in male breast carcinoma tissues, and estrogen producing enzymes were significantly detected in male breast carcinoma tissues. All cases examined in this study were positive for estrogen receptor (ER), and significant association was detected between ER and progesterone receptor. Microarray analysis did demonstrate that expression profiles of estrogen responsive genes are markedly different between male and female breast carcinomas.
Therfefore, it was suggested that estrogens were loccally produced in male breast carcinoma tissues as well as female ones, while its action was quite different between male and female breast carcinomas.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma : comparison with female breast carcinoma2013
Author(s)
Takagi K, Moriya T, Kurosumi M, Oka K, Miki Y, Ebata A, Toshima T, Tsunekawa S, Takei H, Hirakawa H, Ishida T, Hayashi S, Kurebayashi J, Sasano H, Suzuki T
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Journal Title
Hormones and Cancer
Volume: 4(1)
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed
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