| Project/Area Number |
24790407
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nihon University |
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Principal Investigator |
MATSUMOTO Jun 日本大学, 生物資源科学部, 准教授 (70296169)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 寄生虫 / エキノコックス / エネルギー代謝 / メタボロミクス / グルコース / トランスポーター / 創薬 / 寄生適応 / 人獣共通寄生虫症 / メタボローム解析 / トランスクリプトーム解析 |
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| Research Abstract |
Echinococcus multilocularis (Em) is a zoonotic parasite, distributed widely in northern hemisphere including Japan. The larval stage of Em causes life-threatening disease in humans called alveolar echinococcosis. The present study aimed to provide an overview of energetic metabolism pathway in Em. The result of metabolomics analysis using larval Em cultured under aerobic/anaerobic condition suggests that the parasite possesses both aerobic and anaerobic metabolic pathways. The presence of the putative anaerobic pathway is consistent with our previous study (Matsumoto et al., 2008), leading us to infer that the parasite uses this unique metabolic pathway to survive in anaerobic conditions in host tissues. In addition, we obtained the complete sequence for 3 glucose transporter genes, which are supposed to be involved in energy uptake by Em. Further analyses on energy metabolism in Em are presently carried out to identify novel targets for chemotherapy of alveolar echinococcosis.
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