Comprehensive phosphoproteomics analysis of herpesvirus pathogenicity

• Project/Area Number: 24790434
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: KATO Akihisa 東京大学, 医科学研究所, 助教 (40581187)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 単純ヘルペスウイルス / リン酸化プロテオーム解析 / vdUTPase / Us3 / 神経病原性 / 中枢神経系 / リン酸化プロテオーム / カプシド / 軸索輸送

Outline of Final Research Achievements

Herpes simplex virus 1 (HSV-1) encodes Us3 protein kinase and a dUTPase (vdUTPase), which are both critical for neurovirulence in the central nerve system (CNS) of mice. We showed that Us3 phosphorylated vdUTPase to up-regulate its enzymatic activity. This phosphorylation was specifically required for neurovirulence in the CNS of mice, but not for pathogenic effects in mouse eyes and vaginas. Low endogenous cellular dUTPase activity in cell cultures and in vivo was linked to lower replication and virulence of a recombinant virus carrying a mutation that precluded phosphorylation of vdUTPase, and overexpression of cellular dUTPase restored HSV-1 neurovirulence in the CNS by the recombinant virus. Our results supported the hypothesis that CNS-specific neurovirulence of HSV-1 involved strict regulation of vdUTPase activity by Us3 phosphorylation, to compensate for the low cellular dUTPase activity in the CNS, to produce efficient viral replication.

Research Products

• [Journal Article] The Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 is Regulated by Phosphorylation at a Specific Site. (2015)
  • Author(s): R. Kobayashi, A. Kato, S. Oda, N. Koyanagi, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interactome Analysis of Herpes Simplex Virus 1 Envelope Glycoprotein H. (2015)
  • Author(s): Y. Hirohata, A. Kato, M. Oyama, H. Kozuka-Hata, N. Koyanagi, J. Arii and Y. Kawaguchi.
  • Journal Title: Microbiology and Immunology Volume: 印刷中 Issue: 6 Pages: 331-7
  • DOI: 10.1111/1348-0421.12255
  • NAID: 40020510068
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-Muscle Myosin Heavy Chain IIB Mediates Herpes Simplex Virus 1 Entry. (2015)
  • Author(s): J. Arii, Y. Hirohata, A. Kato and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 89 Issue: 3 Pages: 1879-88
  • DOI: 10.1128/jvi.03079-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System. (2015)
  • Author(s): A. Kato, J. Arii, Y. Koyanagi, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 89 Issue: 1 Pages: 241-8
  • DOI: 10.1128/jvi.02497-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation. (2014)
  • Author(s): H. Fujii, A. Kato, M. Mugitani, Y. Kashima, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 88 Issue: 18 Pages: 10624-34
  • DOI: 10.1128/jvi.01634-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphorylation of Herpes Simplex Virus 1 dUTPase Up-regulated Viral dUTPase Activity to Compensate for Low Cellular dUTPase Activity for Efficient Viral Replication. (2014)
  • Author(s): A. Kato, Y. Hirohata, J. Arii, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 88 Issue: 14 Pages: 7776-85
  • DOI: 10.1128/jvi.00603-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Role of Herpes Simplex Virus 1 Immediate-Early Protein ICP22 in Viral Nuclear Egress. (2014)
  • Author(s): Y. Maruzuru, K. Shindo, Z. Liu, M. Oyama, H. Kozuka-Hata, J. Arii, A. Kato and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 88 Issue: 13 Pages: 7445-54
  • DOI: 10.1128/jvi.01057-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress. (2014)
  • Author(s): Z. Liu, A. Kato, K. Shindo, T. Noda, H. Sagara, Y. Kawaoka, J. Arii, and Y. Kawaguchi.
  • Journal Title: Jounarl of Virology Volume: 88 Issue: 9 Pages: 4657-67
  • DOI: 10.1128/jvi.00137-14
  • Peer Reviewed / Open Access
• [Journal Article] Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery. (2014)
  • Author(s): A. Kato, K. Shindo, Y. Maruzuru, and Y. Kawaguchi.
  • Journal Title: Jounarl of Virology Volume: 88 Issue: 5 Pages: 2775-85
  • DOI: 10.1128/jvi.03300-13
  • Peer Reviewed / Open Access
• [Journal Article] Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence. (2014)
  • Author(s): Fujii H, Mugitani M, Koyanagi N, Liu Z, Tsuda S, Arii J, Kato A, Kawaguchi Y.
  • Journal Title: Journal of Virology Volume: VOL. 88 Issue: 4 Pages: 2359-2364
  • DOI: 10.1128/jvi.03621-13
  • Peer Reviewed / Open Access
• [Journal Article] Roles of herpes simplex virus 1 Us3 in viral neuroinvasiveness. (2014)
  • Author(s): N. Koyanagi, T. Imai, J. Arii, A. Kato and Y. Kawaguchi.
  • Journal Title: Microbiology and Immunology Volume: 58 Issue: 1 Pages: 31-37
  • DOI: 10.1111/1348-0421.12108
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli (2014)
  • Author(s): Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K and Akimitsu N.
  • Journal Title: Molecular cell Volume: 53 Issue: 3 Pages: 393
  • DOI: 10.1016/j.molcel.2014.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral dUTPase and Regulates Its Catalytic Activity in Infected Cells. (2014)
  • Author(s): Kato A, Tsuda S, Liu Z, Kozuka-Hata H, Oyama M, and Kawaguchi Y.
  • Journal Title: J Virol Volume: 88 Issue: 1 Pages: 655-666
  • DOI: 10.1128/jvi.02710-13
  • Peer Reviewed / Open Access
• [Journal Article] Roles of p53 in herpes simplex virus 1 replication. (2013)
  • Author(s): Maruzuru Y, Fujii H, Oyama M, Kozuka-Hata H, Kato A, and Kawaguchi Y.
  • Journal Title: J Virol Volume: 87 Issue: 16 Pages: 9323-9332
  • DOI: 10.1128/jvi.01581-13
  • Peer Reviewed
• [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates down regulation of cell surface major histocompatibility complex class Iand evasion of CD8+ T cells. (2013)
  • Author(s): Imai, T., et al.
  • Journal Title: PLos One Volume: 8 Issue: 8 Pages: e72050-e72050
  • DOI: 10.1371/journal.pone.0072050
  • Peer Reviewed
• [Journal Article] Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes (2012)
  • Author(s): Tanaka M, Kato A, Satoh Y, Ide T, Sagou K, Kimura K, Hasegawa H, Kawaguchi Y.
  • Journal Title: neurovirulence Volume: 86(9) Issue: 9 Pages: 5264-77
  • DOI: 10.1128/jvi.06913-11
  • Peer Reviewed
• [Presentation] HSV-1 gDの細胞内領域に存在するアルギニンクラスターは宿主細胞の膜変性と効率的なエンベロープ獲得に寄与する (2014)
  • Author(s): 有井潤、加藤哲久、川口寧
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] ヘルペスウイルス科で保存されているHSV-1テグメント蛋白質UL51とUL14の協調的機能の証明 (2014)
  • Author(s): 尾田真也、有井潤、加藤哲久、川口寧
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] HSV-1感染現象におけるEondosomal sorting protein SNX3リン酸化の生物学的意義の解明 (2014)
  • Author(s): 加藤哲久、尾田真也、有井潤、川口寧
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] HSV-1キャプシドタンパク質VP26のリン酸化はウイルス増殖および病態発現に寄与する (2014)
  • Author(s): 小林亮介、加藤哲久、有井潤、川口寧
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 中枢神経系における新規HSV-1宿主免疫回避機構の解明：HSV-1プロテインキナーゼUL13はCXCL9の発現を抑制し、中枢神経系へのCD8+ T細胞の浸潤を阻害する (2014)
  • Author(s): 小栁直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 単純ヘルペスウイルス1型感染阻害物質の探索 (2014)
  • Author(s): 前田直良、古川敦、坂本二郎、黒木喜美子、尾瀬農之、柿田浩輔、穴田仁洋、橋本俊一、有井潤、加藤哲久、川口寧、荒瀬尚、前仲勝実
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Central nervous system specific virulence of herpes simplex virus involves phosphorylation of a viral dUTPase by a viral protein kinase (2014)
  • Author(s): A. Kato
  • Organizer: The International Symposium ‘Molecular basis of host cell competency in virus infection’
  • Place of Presentation: パシフィコ横浜会議センター (神奈川県横浜市)
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] ヘルペスウイルス科で保存されているHSV-1テグメント蛋白質 UL51とUL14の協調的機能の解明 (2014)
  • Author(s): 尾田真也、有井 潤、加藤哲久、川口 寧
  • Organizer: 第 11 回ウイルス学キャンプ in 湯河原
  • Place of Presentation: ニューウェルシティ湯河原 (静岡県熱海市)
  • Year and Date: 2014-09-17 – 2014-09-18
• [Presentation] Identification of cellular proteins that interact with Herpes Simplex Virus 1 ICP0 (2014)
  • Author(s): 佐藤由佳、有井 潤、加藤哲久、川口 寧
  • Organizer: 第 11 回ウイルス学キャンプ in 湯河原
  • Place of Presentation: ニューウェルシティ湯河原 (静岡県熱海市)
  • Year and Date: 2014-09-17 – 2014-09-18
• [Presentation] 単純ヘルペスウイルスによる細胞傷害性T細胞回避機構の解析 (2014)
  • Author(s): 津田 峻平、小栁 直人、有井 潤、加藤 哲久、川口 寧
  • Organizer: 第 11 回ウイルス学キャンプ in 湯河原
  • Place of Presentation: ニューウェルシティ湯河原 (静岡県熱海市)
  • Year and Date: 2014-09-17 – 2014-09-18
• [Presentation] The arginine cluster located at the terminus of the HSV-1 glycoprotein D cytoplasmic domain is required for membrane deformation and for efficient viral secondary envelopment (2014)
  • Author(s): J. Arii, A. Kato and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] HSV-1 Us3 phosphorylates sorting necxin 3 to inhibit the lysosomal degradation of glycoprotein D by promoting its interaction with phosphatidylinositol-3-phosphate (2014)
  • Author(s): A. Kato, J. Arii and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] HSV-1 recruits CD98hc to the nuclear membrane for fusion between the viral envelope and the outer nuclear membrane (2014)
  • Author(s): Y. Hirohata, J. Arii, K. Shindo, Z. Liu, M, Oyama, H. Kozuka-Hata, H. Sagara, A. Kato and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] The HSV-1 capsid protein VP26 is functionally regulated by phosphorylation in vitro and in vivo (2014)
  • Author(s): R. Kobayashi, A. Kato, J. Arii and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] Characterization of a recombinant chimera HSV-1 in which its Us3 gene is substituted with the HSV-2 Us3 gene (2014)
  • Author(s): K. Shindo, J. Arii, A. Kato and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] Role of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress (2014)
  • Author(s): Y. Maruzuru, K. Shindo, Z. Liu, M. Oyama, H. Kozuka-Hata, J. Arii, A. Kato and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] The HSV-1 UL13 protein kinase down-regulates expression of a cytokine to inhibit CD8+ T cell infiltration into the central nervous system (2014)
  • Author(s): N. Koyanagi, T. Imai, K. Shindo, J. Arii, A. Kato and Y. Kawaguchi
  • Organizer: The 39th Annual international Herpesvirus Workshop
  • Place of Presentation: Kobe International Exhibition Hall (兵庫県神戸市)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] HSV-1 Nucleae UL12の酵素活性およびタイロシンリン酸化のウイルス増殖・病態への関与 (2013)
  • Author(s): 藤井ひかる、麥谷道生、津田峻平、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] HSV-1遺伝子発現調節因子ICP22の新規機能ーウイルス核出芽の制御ー (2013)
  • Author(s): 丸鶴雄平、神道慶子、劉卓明、小柳直人、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] HSV-1成熟粒子への宿主細胞因子取り込み制御機構 (2013)
  • Author(s): 小川遼、佐合健、小柳直人、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] 単純ヘルペスウイルス1型プロテインキナーゼUL13は中枢神経系において宿主免疫回避に寄与する (2013)
  • Author(s): 小柳直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] Noo-Muscle Myosin Heavy Chain IIBは、HSV-1の侵入を仲介するco-receptorである (2013)
  • Author(s): 有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] 単純ヘルペスウイルスUs3プロテインキナーゼによる宿主細胞改変機構の解明 (2013)
  • Author(s): 加藤哲久、廣畑吉崇、尾田真也、有井潤、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] HSVプロテインキナーゼUs3の血清型間差異の解析 (2013)
  • Author(s): 神道慶子、小柳直人、今井孝彦、劉卓明、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] HSV-1主要構成因子UL47は宿主細胞因子p32と相互作用し、ウイルスの核出芽を制御する (2013)
  • Author(s): 劉卓明、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] CD98hcはHSV-1 gBと相互作用し、gBの安定化およびウイルスの出芽を制御する (2013)
  • Author(s): 廣畑吉崇、有井潤、加藤哲久、川口寧
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] A Cellular Protein p32, which is recruited to the Nuclear Membranes by HSV-1 UL47, is Involved in Nuclear Egress of Nucleocapsids (2013)
  • Author(s): Zhuoming Liu, Keiko Shindo, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 38th Annual International Herpesvirus Workshop
  • Place of Presentation: DeVos Place Convention Center(アメリカ)
• [Presentation] Identification of an Endosomal Sorting Protein SNX3 as a Novel Host Cellular Substrate of HSV-1 Us3 (2013)
  • Author(s): Akihisa Kato, Yoshitaka Hirohata, Shinya Oda, Jun Arii, Yasushi Kawaguchi
  • Organizer: 38th Annual International Herpesvirus Workshop
  • Place of Presentation: DeVos Place Convention Center(アメリカ)
• [Presentation] CD98 Hevey Chain Stabilizes HSV-1 gB and Contributes to Viral Replication (2013)
  • Author(s): Yoshitaka Hirohata, Jun Arii, Akihisa Kato, Yasushi kawaguchi
  • Organizer: 38th Annual International Herpesvirus Workshop
  • Place of Presentation: DeVos Place Convention Center(アメリカ)
• [Presentation] HSV-1 Protein Kinase UL13 Inhibits Infiltration of CD+8 T Lymphocytes into Viral Infection Sites in the Central Nervous System (2013)
  • Author(s): Naoto Koyanagi, Takahiko Imai, Keiko Shindo, jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 38th Annual International Herpesvirus Workshop
  • Place of Presentation: DeVos Place Convention Center(アメリカ)
• [Presentation] Non-Muscle Myosin Heavy Chain IIB Associates with Herpes Simplex Virus 1 Envelope Glycoprotein B and Mediates Viral Entry (2013)
  • Author(s): Jun Arii, Kato Akihisa, Kawaguchi Yasushi
  • Organizer: The 12th Awaji International Forum on infection and Immunity
  • Place of Presentation: Awaji Yumebutai International Conference Center(兵庫県)
• [Presentation] The endosomal sorting protein SNX3 is phosphorylated by herpes simplex virus 1 protein kinase Us3 and plays a critical role in viral replication and pathogenesis (2013)
  • Author(s): Akihisa Kato, Yoshitaka Hirohata, Shinya Oda, Jun Arii, Yasushi Kawaguchi
  • Organizer: The 12th Awaji International Forum on infection and Immunity
  • Place of Presentation: Awaji Yumebutai International Conference Center(兵庫県)
• [Presentation] CD98hcは、HSV-1 gBと相互作用し、gBの安定化およびウイルス増殖に寄与する (2013)
  • Author(s): 廣畑吉崇、有井潤、加藤哲久、川口寧
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] 感染細胞におけるUL47複合体構成成分の同定 (2013)
  • Author(s): 劉卓明、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] HSV-1 UL13の中枢神経系における役割 (2013)
  • Author(s): 小柳直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] Non-Muscle Myosin Heavy Chain IIBはHSV-1 gBと結合し、HSV-1の侵入を仲介する (2013)
  • Author(s): 有井潤、加藤哲久、川口寧
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] 宿主因子p32はHSV-1のNuclear Egressを制御し、ウイルスの効率的な増殖に寄与する (2013)
  • Author(s): 劉卓明、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] Us3新規宿主細胞基質の同定とその生物学的意義の解明 (2013)
  • Author(s): 加藤哲久、廣畑吉崇、尾田真也、有井潤、川口寧
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫県)
• [Presentation] HSV PK Us3が司る病態発現機構 (2012)
  • Author(s): 加藤哲久
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊舘プラザホール
• [Presentation] HSV-1 Us3によるMHC Class I阻害の分子機構と生体レベルにおける意義 (2012)
  • Author(s): 加藤哲久
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊舘プラザホール
• [Presentation] The catalytic activity of HSV-1 dUTPase and its regulation are specifically required for efficient viral replication and pathogenicity in the brain (2012)
  • Author(s): Akihisa Kato
  • Organizer: 37th Annual International Herpersvirus Workshop (IHW)
  • Place of Presentation: Calgary- Alberta, Canada
• [Presentation] 単純ヘルペスウイルス１型プロテインキナーゼUs3による神経病原性発現の分子機構 (2012)
  • Author(s): 加藤哲久
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪国際会議場）
• [Presentation] 単純ヘルペスウイルス１型プロテインキナーゼUs3による宿主免疫回避機構と生体レベルにおける意義 (2012)
  • Author(s): 加藤哲久
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪国際会議場）
• [Book] 日本臨牀 (2012)
  • Author(s): 加藤哲久
  • Publisher: 日本臨牀社
• [Remarks] 東京大学医科学研究所 感染・免疫部門 ウイルス病態制御分野ホームページ
  • URL: http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/kawaguchilabtop.html