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Comprehensive phosphoproteomics analysis of herpesvirus pathogenicity

Research Project

Project/Area Number 24790434
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionThe University of Tokyo

Principal Investigator

KATO Akihisa  東京大学, 医科学研究所, 助教 (40581187)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords単純ヘルペスウイルス / リン酸化プロテオーム解析 / vdUTPase / Us3 / 神経病原性 / 中枢神経系 / リン酸化プロテオーム / カプシド / 軸索輸送
Outline of Final Research Achievements

Herpes simplex virus 1 (HSV-1) encodes Us3 protein kinase and a dUTPase (vdUTPase), which are both critical for neurovirulence in the central nerve system (CNS) of mice. We showed that Us3 phosphorylated vdUTPase to up-regulate its enzymatic activity. This phosphorylation was specifically required for neurovirulence in the CNS of mice, but not for pathogenic effects in mouse eyes and vaginas. Low endogenous cellular dUTPase activity in cell cultures and in vivo was linked to lower replication and virulence of a recombinant virus carrying a mutation that precluded phosphorylation of vdUTPase, and overexpression of cellular dUTPase restored HSV-1 neurovirulence in the CNS by the recombinant virus. Our results supported the hypothesis that CNS-specific neurovirulence of HSV-1 involved strict regulation of vdUTPase activity by Us3 phosphorylation, to compensate for the low cellular dUTPase activity in the CNS, to produce efficient viral replication.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (61 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 12 results,  Acknowledgement Compliant: 8 results) Presentation (43 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 is Regulated by Phosphorylation at a Specific Site.2015

    • Author(s)
      R. Kobayashi, A. Kato, S. Oda, N. Koyanagi, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interactome Analysis of Herpes Simplex Virus 1 Envelope Glycoprotein H.2015

    • Author(s)
      Y. Hirohata, A. Kato, M. Oyama, H. Kozuka-Hata, N. Koyanagi, J. Arii and Y. Kawaguchi.
    • Journal Title

      Microbiology and Immunology

      Volume: 印刷中 Issue: 6 Pages: 331-7

    • DOI

      10.1111/1348-0421.12255

    • NAID

      40020510068

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-Muscle Myosin Heavy Chain IIB Mediates Herpes Simplex Virus 1 Entry.2015

    • Author(s)
      J. Arii, Y. Hirohata, A. Kato and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 3 Pages: 1879-88

    • DOI

      10.1128/jvi.03079-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System.2015

    • Author(s)
      A. Kato, J. Arii, Y. Koyanagi, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 1 Pages: 241-8

    • DOI

      10.1128/jvi.02497-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation.2014

    • Author(s)
      H. Fujii, A. Kato, M. Mugitani, Y. Kashima, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 88 Issue: 18 Pages: 10624-34

    • DOI

      10.1128/jvi.01634-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphorylation of Herpes Simplex Virus 1 dUTPase Up-regulated Viral dUTPase Activity to Compensate for Low Cellular dUTPase Activity for Efficient Viral Replication.2014

    • Author(s)
      A. Kato, Y. Hirohata, J. Arii, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 88 Issue: 14 Pages: 7776-85

    • DOI

      10.1128/jvi.00603-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Role of Herpes Simplex Virus 1 Immediate-Early Protein ICP22 in Viral Nuclear Egress.2014

    • Author(s)
      Y. Maruzuru, K. Shindo, Z. Liu, M. Oyama, H. Kozuka-Hata, J. Arii, A. Kato and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 88 Issue: 13 Pages: 7445-54

    • DOI

      10.1128/jvi.01057-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress.2014

    • Author(s)
      Z. Liu, A. Kato, K. Shindo, T. Noda, H. Sagara, Y. Kawaoka, J. Arii, and Y. Kawaguchi.
    • Journal Title

      Jounarl of Virology

      Volume: 88 Issue: 9 Pages: 4657-67

    • DOI

      10.1128/jvi.00137-14

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.2014

    • Author(s)
      A. Kato, K. Shindo, Y. Maruzuru, and Y. Kawaguchi.
    • Journal Title

      Jounarl of Virology

      Volume: 88 Issue: 5 Pages: 2775-85

    • DOI

      10.1128/jvi.03300-13

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence.2014

    • Author(s)
      Fujii H, Mugitani M, Koyanagi N, Liu Z, Tsuda S, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      Journal of Virology

      Volume: VOL. 88 Issue: 4 Pages: 2359-2364

    • DOI

      10.1128/jvi.03621-13

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of herpes simplex virus 1 Us3 in viral neuroinvasiveness.2014

    • Author(s)
      N. Koyanagi, T. Imai, J. Arii, A. Kato and Y. Kawaguchi.
    • Journal Title

      Microbiology and Immunology

      Volume: 58 Issue: 1 Pages: 31-37

    • DOI

      10.1111/1348-0421.12108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli2014

    • Author(s)
      Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K and Akimitsu N.
    • Journal Title

      Molecular cell

      Volume: 53 Issue: 3 Pages: 393

    • DOI

      10.1016/j.molcel.2014.01.009

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral dUTPase and Regulates Its Catalytic Activity in Infected Cells.2014

    • Author(s)
      Kato A, Tsuda S, Liu Z, Kozuka-Hata H, Oyama M, and Kawaguchi Y.
    • Journal Title

      J Virol

      Volume: 88 Issue: 1 Pages: 655-666

    • DOI

      10.1128/jvi.02710-13

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of p53 in herpes simplex virus 1 replication.2013

    • Author(s)
      Maruzuru Y, Fujii H, Oyama M, Kozuka-Hata H, Kato A, and Kawaguchi Y.
    • Journal Title

      J Virol

      Volume: 87 Issue: 16 Pages: 9323-9332

    • DOI

      10.1128/jvi.01581-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates down regulation of cell surface major histocompatibility complex class Iand evasion of CD8+ T cells.2013

    • Author(s)
      Imai, T., et al.
    • Journal Title

      PLos One

      Volume: 8 Issue: 8 Pages: e72050-e72050

    • DOI

      10.1371/journal.pone.0072050

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes2012

    • Author(s)
      Tanaka M, Kato A, Satoh Y, Ide T, Sagou K, Kimura K, Hasegawa H, Kawaguchi Y.
    • Journal Title

      neurovirulence

      Volume: 86(9) Issue: 9 Pages: 5264-77

    • DOI

      10.1128/jvi.06913-11

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] HSV-1 gDの細胞内領域に存在するアルギニンクラスターは宿主細胞の膜変性と効率的なエンベロープ獲得に寄与する2014

    • Author(s)
      有井潤、加藤哲久、川口寧
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヘルペスウイルス科で保存されているHSV-1テグメント蛋白質UL51とUL14の協調的機能の証明2014

    • Author(s)
      尾田真也、有井潤、加藤哲久、川口寧
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSV-1感染現象におけるEondosomal sorting protein SNX3リン酸化の生物学的意義の解明2014

    • Author(s)
      加藤哲久、尾田真也、有井潤、川口寧
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSV-1キャプシドタンパク質VP26のリン酸化はウイルス増殖および病態発現に寄与する2014

    • Author(s)
      小林亮介、加藤哲久、有井潤、川口寧
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢神経系における新規HSV-1宿主免疫回避機構の解明:HSV-1プロテインキナーゼUL13はCXCL9の発現を抑制し、中枢神経系へのCD8+ T細胞の浸潤を阻害する2014

    • Author(s)
      小栁直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単純ヘルペスウイルス1型感染阻害物質の探索2014

    • Author(s)
      前田直良、古川敦、坂本二郎、黒木喜美子、尾瀬農之、柿田浩輔、穴田仁洋、橋本俊一、有井潤、加藤哲久、川口寧、荒瀬尚、前仲勝実
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Central nervous system specific virulence of herpes simplex virus involves phosphorylation of a viral dUTPase by a viral protein kinase2014

    • Author(s)
      A. Kato
    • Organizer
      The International Symposium ‘Molecular basis of host cell competency in virus infection’
    • Place of Presentation
      パシフィコ横浜会議センター (神奈川県横浜市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヘルペスウイルス科で保存されているHSV-1テグメント蛋白質 UL51とUL14の協調的機能の解明2014

    • Author(s)
      尾田真也、有井 潤、加藤哲久、川口 寧
    • Organizer
      第 11 回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      ニューウェルシティ湯河原 (静岡県熱海市)
    • Year and Date
      2014-09-17 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of cellular proteins that interact with Herpes Simplex Virus 1 ICP02014

    • Author(s)
      佐藤由佳、有井 潤、加藤哲久、川口 寧
    • Organizer
      第 11 回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      ニューウェルシティ湯河原 (静岡県熱海市)
    • Year and Date
      2014-09-17 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単純ヘルペスウイルスによる細胞傷害性T細胞回避機構の解析2014

    • Author(s)
      津田 峻平、小栁 直人、有井 潤、加藤 哲久、川口 寧
    • Organizer
      第 11 回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      ニューウェルシティ湯河原 (静岡県熱海市)
    • Year and Date
      2014-09-17 – 2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] The arginine cluster located at the terminus of the HSV-1 glycoprotein D cytoplasmic domain is required for membrane deformation and for efficient viral secondary envelopment2014

    • Author(s)
      J. Arii, A. Kato and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSV-1 Us3 phosphorylates sorting necxin 3 to inhibit the lysosomal degradation of glycoprotein D by promoting its interaction with phosphatidylinositol-3-phosphate2014

    • Author(s)
      A. Kato, J. Arii and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSV-1 recruits CD98hc to the nuclear membrane for fusion between the viral envelope and the outer nuclear membrane2014

    • Author(s)
      Y. Hirohata, J. Arii, K. Shindo, Z. Liu, M, Oyama, H. Kozuka-Hata, H. Sagara, A. Kato and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] The HSV-1 capsid protein VP26 is functionally regulated by phosphorylation in vitro and in vivo2014

    • Author(s)
      R. Kobayashi, A. Kato, J. Arii and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of a recombinant chimera HSV-1 in which its Us3 gene is substituted with the HSV-2 Us3 gene2014

    • Author(s)
      K. Shindo, J. Arii, A. Kato and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress2014

    • Author(s)
      Y. Maruzuru, K. Shindo, Z. Liu, M. Oyama, H. Kozuka-Hata, J. Arii, A. Kato and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] The HSV-1 UL13 protein kinase down-regulates expression of a cytokine to inhibit CD8+ T cell infiltration into the central nervous system2014

    • Author(s)
      N. Koyanagi, T. Imai, K. Shindo, J. Arii, A. Kato and Y. Kawaguchi
    • Organizer
      The 39th Annual international Herpesvirus Workshop
    • Place of Presentation
      Kobe International Exhibition Hall (兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSV-1 Nucleae UL12の酵素活性およびタイロシンリン酸化のウイルス増殖・病態への関与2013

    • Author(s)
      藤井ひかる、麥谷道生、津田峻平、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSV-1遺伝子発現調節因子ICP22の新規機能ーウイルス核出芽の制御ー2013

    • Author(s)
      丸鶴雄平、神道慶子、劉卓明、小柳直人、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSV-1成熟粒子への宿主細胞因子取り込み制御機構2013

    • Author(s)
      小川遼、佐合健、小柳直人、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 単純ヘルペスウイルス1型プロテインキナーゼUL13は中枢神経系において宿主免疫回避に寄与する2013

    • Author(s)
      小柳直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Noo-Muscle Myosin Heavy Chain IIBは、HSV-1の侵入を仲介するco-receptorである2013

    • Author(s)
      有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 単純ヘルペスウイルスUs3プロテインキナーゼによる宿主細胞改変機構の解明2013

    • Author(s)
      加藤哲久、廣畑吉崇、尾田真也、有井潤、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSVプロテインキナーゼUs3の血清型間差異の解析2013

    • Author(s)
      神道慶子、小柳直人、今井孝彦、劉卓明、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSV-1主要構成因子UL47は宿主細胞因子p32と相互作用し、ウイルスの核出芽を制御する2013

    • Author(s)
      劉卓明、神道慶子、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] CD98hcはHSV-1 gBと相互作用し、gBの安定化およびウイルスの出芽を制御する2013

    • Author(s)
      廣畑吉崇、有井潤、加藤哲久、川口寧
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] A Cellular Protein p32, which is recruited to the Nuclear Membranes by HSV-1 UL47, is Involved in Nuclear Egress of Nucleocapsids2013

    • Author(s)
      Zhuoming Liu, Keiko Shindo, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      38th Annual International Herpesvirus Workshop
    • Place of Presentation
      DeVos Place Convention Center(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of an Endosomal Sorting Protein SNX3 as a Novel Host Cellular Substrate of HSV-1 Us32013

    • Author(s)
      Akihisa Kato, Yoshitaka Hirohata, Shinya Oda, Jun Arii, Yasushi Kawaguchi
    • Organizer
      38th Annual International Herpesvirus Workshop
    • Place of Presentation
      DeVos Place Convention Center(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] CD98 Hevey Chain Stabilizes HSV-1 gB and Contributes to Viral Replication2013

    • Author(s)
      Yoshitaka Hirohata, Jun Arii, Akihisa Kato, Yasushi kawaguchi
    • Organizer
      38th Annual International Herpesvirus Workshop
    • Place of Presentation
      DeVos Place Convention Center(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSV-1 Protein Kinase UL13 Inhibits Infiltration of CD+8 T Lymphocytes into Viral Infection Sites in the Central Nervous System2013

    • Author(s)
      Naoto Koyanagi, Takahiko Imai, Keiko Shindo, jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      38th Annual International Herpesvirus Workshop
    • Place of Presentation
      DeVos Place Convention Center(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Non-Muscle Myosin Heavy Chain IIB Associates with Herpes Simplex Virus 1 Envelope Glycoprotein B and Mediates Viral Entry2013

    • Author(s)
      Jun Arii, Kato Akihisa, Kawaguchi Yasushi
    • Organizer
      The 12th Awaji International Forum on infection and Immunity
    • Place of Presentation
      Awaji Yumebutai International Conference Center(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] The endosomal sorting protein SNX3 is phosphorylated by herpes simplex virus 1 protein kinase Us3 and plays a critical role in viral replication and pathogenesis2013

    • Author(s)
      Akihisa Kato, Yoshitaka Hirohata, Shinya Oda, Jun Arii, Yasushi Kawaguchi
    • Organizer
      The 12th Awaji International Forum on infection and Immunity
    • Place of Presentation
      Awaji Yumebutai International Conference Center(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] CD98hcは、HSV-1 gBと相互作用し、gBの安定化およびウイルス増殖に寄与する2013

    • Author(s)
      廣畑吉崇、有井潤、加藤哲久、川口寧
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 感染細胞におけるUL47複合体構成成分の同定2013

    • Author(s)
      劉卓明、神道慶子、有井潤、加藤哲久、川口寧
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSV-1 UL13の中枢神経系における役割2013

    • Author(s)
      小柳直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Non-Muscle Myosin Heavy Chain IIBはHSV-1 gBと結合し、HSV-1の侵入を仲介する2013

    • Author(s)
      有井潤、加藤哲久、川口寧
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 宿主因子p32はHSV-1のNuclear Egressを制御し、ウイルスの効率的な増殖に寄与する2013

    • Author(s)
      劉卓明、神道慶子、有井潤、加藤哲久、川口寧
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Us3新規宿主細胞基質の同定とその生物学的意義の解明2013

    • Author(s)
      加藤哲久、廣畑吉崇、尾田真也、有井潤、川口寧
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Presentation] HSV PK Us3が司る病態発現機構2012

    • Author(s)
      加藤哲久
    • Organizer
      第27回ヘルペスウイルス研究会
    • Place of Presentation
      あいち健康プラザ健康宿泊舘プラザホール
    • Related Report
      2012 Research-status Report
  • [Presentation] HSV-1 Us3によるMHC Class I阻害の分子機構と生体レベルにおける意義2012

    • Author(s)
      加藤哲久
    • Organizer
      第27回ヘルペスウイルス研究会
    • Place of Presentation
      あいち健康プラザ健康宿泊舘プラザホール
    • Related Report
      2012 Research-status Report
  • [Presentation] The catalytic activity of HSV-1 dUTPase and its regulation are specifically required for efficient viral replication and pathogenicity in the brain2012

    • Author(s)
      Akihisa Kato
    • Organizer
      37th Annual International Herpersvirus Workshop (IHW)
    • Place of Presentation
      Calgary- Alberta, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 単純ヘルペスウイルス1型プロテインキナーゼUs3による神経病原性発現の分子機構2012

    • Author(s)
      加藤哲久
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪(大阪国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] 単純ヘルペスウイルス1型プロテインキナーゼUs3による宿主免疫回避機構と生体レベルにおける意義2012

    • Author(s)
      加藤哲久
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪(大阪国際会議場)
    • Related Report
      2012 Research-status Report
  • [Book] 日本臨牀2012

    • Author(s)
      加藤哲久
    • Publisher
      日本臨牀社
    • Related Report
      2012 Research-status Report
  • [Remarks] 東京大学医科学研究所 感染・免疫部門 ウイルス病態制御分野ホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/kawaguchilabtop.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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