Molecular mechanism of mitophagy and its application to the laboratory medicine

Research Project

Project/Area Number	24790556
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Laboratory medicine
Research Institution	Kyushu University
Principal Investigator	AOKI Yoshimasa 九州大学, 大学病院, 主任臨床検査技師 (80419514)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	マイトファジー / ミトコンドリア
Outline of Final Research Achievements	Mitophagy is a process that degrade mitochondria selectively. In this study, we investigated the signaling pathways that regulate mitophagy using yeast and human cell lines. We further try to establish the method to detect the mitophagy using clinical laboratory test. We found that, in human cells, MAP kinase Erk2 and p38 related signaling pathways are important for mitophagy. In addition, we found that mitophagy dispensable protein Atg32 is expressed under the regulation of TOR and the down Ume6-Sin3-Rpd3 complex.

Report

(4 results)