Investigation of involvement of epigenetic regulation in pathogenic mechanism of indium lung

• Project/Area Number: 24790588
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: Kochi University
• Principal Investigator: EITOKU Masamitsu 高知大学, 教育研究部医療学系, 助教 (50552733)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インジウム化合物 / 産業医学 / エピジェネティクス / 呼吸器炎症 / 酸化ストレス

Outline of Final Research Achievements

Intratracheal instillation of indium oxide successfully caused indium lung in mice. Lung tissues of mice with indium lung revealed feature of pulmonary alveolar proteinosis. Comprehensive analyses of gene expression by RNA-Seq exhibited that the markers for interstitial abnormalities were expressed in indium exposed mice group. These results may provide a clue for the therapeutic development of indium lung. The indium mice model developed by intratracheal instillation method contributes the proceeding of future research in indium lung.

Research Products

• [Journal Article] Selenium and exposure to fibrogenic mineral dust: a mini-review. (2015)
  • Author(s): Muzembo BA, Yoji Deguchi, Nlandu Roger Ngatu, Masamitsu Eitoku, Ryoji Hirota, Narufumi Suganuma.
  • Journal Title: Environ Int. Volume: 20 (77C) Pages: 16-24
  • DOI: 10.1016/j.envint.2015.01.002
  • Peer Reviewed
• [Journal Article] Workplace violence towards Congolese health care workers: A survey of 436 healthcare facilities in Katanga province, Democratic Republic of Congo (2015)
  • Author(s): Muzembo BA, Lukuke Hendrick MBUTSHU, Nlandu Roger NGATU, Kaj Francoise MALONGA, Masamitsu EITOKU, Ryoji HIROTA,and Narufumi SUGANUMA.
  • Journal Title: Journal of Occupational Health Volume: 57 Issue: 1 Pages: 69-80
  • DOI: 10.1539/joh.14-0111-OA
  • NAID: 130004704508
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of Occupational Allergy in Medical Researchers Exposed to Laboratory Animals. (2014)
  • Author(s): Muzembo BA, Eitoku M, Inaoka Y, Oogiku M, Kawakubo M, Tai R, Takechi M, Hirabayashi KI, Yoshida N, Ngatu NR, Hirota R, Sandjaya B, Suganuma N.
  • Journal Title: Ind Health. Volume: 52 Pages: 256-261
  • NAID: 130004483619
  • Peer Reviewed
• [Journal Article] Variability of subseafloor viral abundance at the geographically and geologically distinct continental margins. (2014)
  • Author(s): Yanagawa, K., Morono, Y., Yoshida-Takashima, Y., Eitoku, M., Sunamura, M., Inagaki, F., Imachi, H., Takai, K., and Nunoura, T.
  • Journal Title: FEMS Microbiol. Ecol. Volume: 12269 Issue: 1 Pages: 60-68
  • DOI: 10.1111/1574-6941.12269
  • Peer Reviewed
• [Journal Article] A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community. (2014)
  • Author(s): Muzembo BA, Nagano Y, Eitoku M, Ngatu NR, Matsui T, Bhatti SA, Hirota R, Ishida K, Suganuma N.
  • Journal Title: Environ Health Prev Med. Volume: 19 Issue: 1 Pages: 21-29
  • DOI: 10.1007/s12199-013-0350-x
  • NAID: 210000000289
  • Peer Reviewed
• [Journal Article] Ankle-brachial pressure index and mini nutritional assessment in community-dwelling elderly people. (2013)
  • Author(s): Muzembo BA, Nagano Y, Dumavibhat N, Ngatu NR, Matsui T, Bhatti SA, Eitoku M, Hirota R, Ishida K, Suganuma N.
  • Journal Title: J Nutr Health Aging Volume: 17 Issue: 4 Pages: 370-376
  • DOI: 10.1007/s12603-012-0412-6
  • Peer Reviewed
• [Journal Article] Radiographic Progression of Silicosis among Japanese Tunnel Workers in Kochi. (2013)
  • Author(s): Dumavibhat N, Matsui T, Hoshino E, Rattanasiri S, Muntham D, Hirota R, Eitoku M, Imanaka M, Muzembo BA, Ngatu NR, Kondo S, Hamada N, Suganuma N.
  • Journal Title: J Occup Health Volume: [Epub ahead of print]
  • NAID: 10031159406
  • Peer Reviewed
• [Journal Article] Metagenomic analysis of viral communities in (hado)pelagic sediments (2013)
  • Author(s): Yoshida M, Takaki Y, Eitoku M, Nunoura T, Takai K
  • Journal Title: PLoS ONE Volume: 8(2) Issue: 2 Pages: e57271-e57271
  • DOI: 10.1371/journal.pone.0057271
  • Peer Reviewed
• [Journal Article] Serum selenium and selenoprotein P in patients with silicosis. (2013)
  • Author(s): Muzembo BA, Dumavibhat N, Ngatu NR, Eitoku M, Hirota R, Kondo S, Deguchi Y, Saito Y, Takahashi K, Suganuma N.
  • Journal Title: J Trace Elem Med Biol Volume: 27 Issue: 1 Pages: 40-44
  • DOI: 10.1016/j.jtemb.2012.05.003
  • Peer Reviewed
• [Journal Article] Mini Nutritional Assessment and functional capacity in community-dwelling elderly in rural Luozi, Democratic Republic of Congo. (2013)
  • Author(s): Andre MB, Dumavibhat N, Ngatu NR, Eitoku M, Hirota R, Suganuma N.
  • Journal Title: Geriatr Gerontol Int Volume: 13 Issue: 1 Pages: 35-42
  • DOI: 10.1111/j.1447-0594.2012.00852.x
  • Peer Reviewed
• [Journal Article] Anti-Allergic Effects of <i>Vernonia amygdalina</i> Leaf Extracts in Hapten-Induced Atopic Dermatitis-Like Disease in Mice (2012)
  • Author(s): Ngatu NR, Okajima MK, Yokogawa M, Hirota R, Takaishi M, Eitoku M, Muzembo BA, Sabah AB, Saruta T, Miyamura M, Kaneko T, Sano S, Suganuma N.
  • Journal Title: Allergology International Volume: 61 Issue: 4 Pages: 597-607
  • DOI: 10.2332/allergolint.11-OA-0393
  • NAID: 130004873053
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated mice (2012)
  • Author(s): Hirota R, Nakamura H, Bhatti SA, Ngatu NR, Muzembo BA, Dumavibhat N, Eitoku M, Sawamura M, Suganuma N
  • Journal Title: Inhal Toxicol Volume: 24(6) Issue: 6 Pages: 373-381
  • DOI: 10.3109/08958378.2012.675528
  • Peer Reviewed
• [Presentation] 酸化インジウムの気管内投与によるアカタラセミアマウスへの健康影響の検討 (2012)
  • Author(s): Eitoku M, Muzembo B, Hirota R, Hirata M, Tanaka A, Furihata M, Ogino K, Suganuma N
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場 （愛知県）
• [Presentation] Effect of intratracheal instillation of Indium oxide to acatalasemic mice (2012)
  • Author(s): Eitoku M, Muzembo B, Hirota R, Hirata M, Tanaka A, Furihata M, Ogino K, Suganuma N
  • Organizer: The 23st Korea Japan China Joint Conference on Occupational Health
  • Place of Presentation: Jirisan Family Hotel (Korea)