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Prevalence of serum celiac antibody in Japan

Research Project

Project/Area Number 24790726
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionNational Defense Medical College

Principal Investigator

WATANABE CHIKAKO  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育学部医学科専門課程, 講師 (90365263)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords下部消化管学 / 粘膜免疫 / セリアック病 / グルテン / 過敏性腸症 / 吸収不良症候群 / 腸管免疫
Research Abstract

[Background] Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers. The aim of this study was to examine the current incidence of celiac disease, especially in IBD patients in Japan, where both wheat consumption and incidence of IBD have increased. [Methods] A total of 172 patients with IBD and 190 controls in Japan were screened for serum antibody of tissue transglutaminase and deaminated gliadin peptide. In sero-positive patients, HLA testing and upper gastrointestinal endoscopy with duodenal biopsy was performed.[Conclusion] Despite the increased incidence of IBD and high positivity for serum celiac antibody in Japanese IBD patients, no true-positive celiac disease was noted, suggesting the presence of gluten intolerance in these populations.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (11 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] Prevalence of serum celiac antibody in patients with IBD in Japan2014

    • Author(s)
      Watanabe C, Komoto S, Hokari R, Kurihara C, Okada Y, Hozumi H, Higashiyama M, Sakuraba A, Tomita K, Tsuzuki Y, Kawaguchi A, Nagao S, Ogata S, Miura S
    • Journal Title

      J. Gastroenterol

      Volume: 49(5) Pages: 825-34

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Issues associated with the emergence of coeliac disease in the Asia.Pacific region : a working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology2014

    • Author(s)
      2.Makharia GK, Mulder CJ, Goh KL, Ahuja V, Bai JC, Catassi C, Green PH, Gupta SD, Lundin KE, Ramakrishna BS, Rawat R, Sharma H, Sood A, Watanabe C, Gibson PR; World Gastroenterology Organization-Asia Pacific Association of Gastroenterology Working Party on Celiac Disease
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 29(4) Pages: 666-77

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Issues associated with the emergence of coeliac disease in the Asia-Pacific region: A working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology2014

    • Author(s)
      Govind K Makharia, Chris J J Mulder, Khean Lee Goh, Vineet Ahuja, Julio C Bai, Carlo Catassi, Peter H R Green, Siddhartha Datta Gupta, Knut E A Lundin, Balakrishnan Siddartha Ramakrishna, Ramakant Rawat, Hanish Sharma, Ajit Sood, Chikako Watanabe and Peter R Gibson
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 29 Pages: 666-677

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of serum celiac antibody in patients with IBD in Japan2013

    • Author(s)
      Watanabe C, Komoto S, Hokari R, Kurihara C, Okada Y, Hozumi H, Higashiyama M, Sakuraba A, Tomita K, Tsuzuki Y, Kawaguchi A, Nagao S, Ogata S, Miura S.
    • Journal Title

      Journal of Gastroenterology

      Volume: xx

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Increased prevalence of celiac specific antibody in Japanese IBD patients and the effect of gluten intake2013

    • Author(s)
      Watanabe C, Komoto S, Kurihara, C, Okada Y, Narimatsu K, Sato H, Hozumi H, Hokar R, Miura S
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando
    • Related Report
      2013 Final Research Report
  • [Presentation] Celiac disease in Japan2013

    • Author(s)
      Chikako Watanabe, Komoto Shunsuke, Ryota hokari, Soichiro Miura
    • Organizer
      Asia Pacific Association of Gastroenterology Focus meeting on celiac disease
    • Place of Presentation
      New Delhi
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prevalence of celiac disease in patients with inflammatory bowel disease : A study from Japan2012

    • Author(s)
      Watanabe C, Hokari R, Kurihara C, Ueda T, Hozumi H, Sato H, Narimatsu K, Okada Y, Sato S, Komoto S, Tomita K, Kawaguchi A, Nagao S, Miura S
    • Organizer
      Disease Week 2012
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 当科におけるセリアック病の実態調査 : 疾患特異的血清抗体と炎症性腸疾患の関連について2012

    • Author(s)
      渡辺知佳子,穂苅量太,高本俊介,三浦総一郎
    • Organizer
      第50回小腸研究会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 我が国における炎症性腸疾患とセリアック病の関連について2012

    • Author(s)
      渡辺知佳子,穂苅量太,三浦総一郎
    • Organizer
      第54回日本消化器病学会大会、第20回日本消化器病週間内合同企画 JDDW 2012
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 本邦におけるセリアック病の実態の臨床調査 ~炎症性腸疾患患者における合併の可能性について ~2012

    • Author(s)
      渡辺知佳子,穂苅量太,高本俊介,冨田謙吾,三浦総一郎
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Prevalence of celiac disease in patients with in􏰄ammatory bowel disease: A study from Japan.2012

    • Author(s)
      Watanabe Chikako,Hokari Ryota, Komoto Shunsuke,Tomita Kengo,Kawaguchi Atsushi,Nagao Shigeaki,Miura Soichiro
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] 本邦におけるセリアック病の実態の臨床調査~炎症性腸疾患患者における合併の可能性について~

    • Author(s)
      渡辺知佳子, 穂苅量太, 高本俊介, 冨田謙吾, 三浦総一郎
    • Organizer
      第 98 回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 我が国における炎症性腸疾患とセリアック病の関連について

    • Author(s)
      渡辺知佳子, 穂苅量太, 三浦総一郎
    • Organizer
      第 54 回日本消化器病学会大会、第 20 回日本消化器病週間内合同企画 JDDW 2012 Kobe,
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 当科におけるセリアック病の実態調査:疾患特異的血清抗体と炎症性腸疾患の関連について

    • Author(s)
      渡辺知佳子, 穂苅量太, 高本俊介, 三浦総一郎
    • Organizer
      第 50 回小腸研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Increased prevalence of celiac specific antibody in Japanese IBD patients and the effect of gluten intake

    • Author(s)
      Watanabe Chikako,Hokari Ryota,Komoto Shunsuke,Tomita Kengo,Kawaguchi Atsushi,Nagao Shigeaki,Miura Soichiro
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orland
    • Related Report
      2012 Research-status Report
  • [Book] セリアック病と炎症性腸疾患臨床免疫・アレルギー科2014

    • Author(s)
      渡辺知佳子、高本俊介、穂苅量太,三浦総一郎
    • Related Report
      2013 Final Research Report
  • [Book] 小腸、大腸および胃の分子標的治療、小俣政男、千葉勉監修、専門医の為の消化器病学第2版2013

    • Author(s)
      渡辺知佳子、三浦総一郎
    • Publisher
      医学書院(東京)
    • Related Report
      2013 Final Research Report
  • [Book] 吸収不良症候群、浅香正博、菅野健太郎、千葉勉編、消化器病学基礎と臨床2013

    • Author(s)
      渡辺知佳子、三浦総一郎
    • Publisher
      西村書店(東京)
    • Related Report
      2013 Final Research Report
  • [Book] 消化器病学 基礎と臨床2013

    • Author(s)
      渡辺知佳子、三浦総一郎
    • Total Pages
      1541
    • Publisher
      西村書店
    • Related Report
      2013 Annual Research Report
  • [Book] 専門医の為の消化器病学第2版2013

    • Author(s)
      渡辺知佳子、三浦総一郎
    • Total Pages
      686
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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