Evaluation of neuropathic pain system using pain-related evoked potentials with C fiber selective electrical stimulation

• Project/Area Number: 24790901
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Clinical research Center, Chiba-East National Hospital, National Hospital Organization
• Principal Investigator: ISOSE Sagiri 独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 (80466698)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 神経障害性疼痛 / 疼痛関連誘発電位 / 末梢神経障害 / 表皮内電気刺激

Research Abstract

We investigated patterns of changes in A delta- and C-mediated brain responses in neuropathic pain, using pain-related evoked potentials (PREPs) with intra-epidermal electrical stimulation (IES) for evaluation of neuropathic pain system. Patients with neuropathic pain have increased C/A delta fiber-PREP amplitude ratios, possibly due to decreased inhibition of the A delta to C nociceptive system leading to generation of neuropathic pain. PREPs with IES could be a useful tool to evaluate changes in neural responses and interaction of the A delta- and C-mediated pain pathways in neuropathic pain patients.

Research Products

• [Journal Article] Bortezomib-induced neuropathy: axonal membrane depolarization precedes development of neuropathy (2014)
  • Author(s): Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S S,
  • Journal Title: Clinical Neurophysiology Volume: 125 Issue: 2 Pages: 381-387
  • DOI: 10.1016/j.clinph.2013.07.014
  • Peer Reviewed
• [Journal Article] Somatotopic representation of pain in the primary somatosensory cortex (S1) in humans (2013)
  • Author(s): Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R
  • Journal Title: Clin Neurophysiol. Volume: 124(7) Issue: 7 Pages: 1422-1430
  • DOI: 10.1016/j.clinph.2013.01.006
  • Peer Reviewed
• [Journal Article] Prominent fatigue in spinal muscular atrophy and spinal and bulbar muscular atrophy: evidence of activity-dependent conduction block. (2013)
  • Author(s): Noto Y, Misawa S, Mori M, Kawaguchi N, Kanai K, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Beppu M, Ohmori S, Nakagawa M, Kuwabara S.
  • Journal Title: Clin Neurophysiol. Volume: 124(9) Issue: 9 Pages: 1893-8
  • DOI: 10.1016/j.clinph.2012.12.053
  • Peer Reviewed
• [Journal Article] Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis. (2012)
  • Author(s): Kanai K, Shibuya K, Sato Y, Misawa S, Nasu S, Sekiguchi Y, Mitsuma S, Isose S, Fujimaki Y, Ohmori S, Koga S, Kuwabara S.
  • Journal Title: J Neurol Neurosurg Psychiatry. Volume: 83 Issue: 7 Pages: 734-8
  • DOI: 10.1136/jnnp-2011-301782
  • NAID: 130004504845
  • Peer Reviewed
• [Journal Article] Differences in excitability between median and superficial radial sensory axons (2012)
  • Author(s): Fujimaki Y, Kanai K, Misawa S, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Ohmori S, Noto Y, Kugio Y, Shimizu T, Matsubara S, Lin CS, Kuwabara S
  • Journal Title: Clin Neurophysiol Volume: 123 Issue: 7 Pages: 1440-5
  • DOI: 10.1016/j.clinph.2011.11.002
  • Peer Reviewed
• [Presentation] PATHOPHYSIOLOGY OF NEUROPATHIC PAIN IN POEMS SYNDROME : STUDY OF PAIN-RELATED EVOKED POTENTIALS (2013)
  • Author(s): Sagiri Isose et al.,(他9名)
  • Organizer: Biennial Meeting of the Peripheral Nerve Society
  • Place of Presentation: Saint.Malo, France
• [Presentation] POEMS 症候群における神経障害性疼痛 : 疼痛関連誘発電位検査による検討 (2013)
  • Author(s): 磯瀬沙希里(他8名)
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知県立県民文化ホール
• [Presentation] POEMS症候群における疼痛発生の機序 : 表皮内小径線維刺激による誘発電位からの検討 (2013)
  • Author(s): 磯瀬沙希里(他9名)
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] PATHOPHYSIOLOGY OF NEUROPATHIC PAIN IN POEMS SYNDROME: STUDY OF PAIN-RELATED EVOKED POTENTIALS. (2013)
  • Author(s): Sagiri Isose et al
  • Organizer: Biennial Meeting of the Peripheral Nerve Society．
  • Place of Presentation: Saint.Malo, France
• [Presentation] POEMS症候群における疼痛発生の機序：表皮内小径線維刺激による誘発電位からの検討 (2013)
  • Author(s): 磯瀬沙希里 他
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 神経障害性疼痛における小径線維刺激による疼痛関連誘発電位の検討：表皮内刺激電極を用いて (2013)
  • Author(s): 大森茂樹、磯瀬沙希里 他
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知県立県民文化ホール 他
• [Presentation] The effects of low-cut filtering on CMAP duration in electrodiagnosis of CIDP (2012)
  • Author(s): Sagiri Isose et al.,(他11 名)
  • Organizer: PNS/Inflammatory Neuropathy Consortium Meeting
  • Place of Presentation: Rotterdam, The Netherlands
• [Presentation] 疼痛関連誘発電位を用いた神経障害性疼痛における中枢性評価へのアプローチ (2012)
  • Author(s): 磯瀬沙希里(他10名)
  • Organizer: 第42回日本臨床神経生理学会学術大会
  • Place of Presentation: 京王プラザホテル)
• [Presentation] CIDPの電気診断における遠位CMAP持続時間 : 低周波フィルターの影響 (2012)
  • Author(s): 磯瀬沙希里(他13名)
  • Organizer: 第23回日本末梢神経学会学術大会
  • Place of Presentation: 九州大学医学部百年講堂)
• [Presentation] 表皮内電気刺激による痛覚誘発電位を用いた神経障害性疼痛の病態 (2012)
  • Author(s): 磯瀬沙希里(他11名)
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 疼痛関連誘発電位を用いた神経障害性疼痛における中枢性評価へのアプローチ (2012)
  • Author(s): 磯瀬沙希里、他10名
  • Organizer: 第42回日本臨床神経生理学会学術大会
  • Place of Presentation: 京王プラザホテル