Role of novel variants of PGC-1alpha in the regulation of energy metabolism
| Project/Area Number |
24790924
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エネルギー・糖質代謝異常 / PGC-1α / 肥満 / エネルギー代謝 / 骨格筋 / PGC1α / 運動 |
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| Research Abstract |
The transcriptional coactivator PGC-1alpha is implicated in the regulation of body mass and insulin sensitivity; however, its contribution to these conditions is unclear. Two recently identified PGC-1alpha variants are transcribed from an alternative promoter and induced by exercise in skeletal muscle. Here we show that mice lacking these variants develop age-dependent obesity and insulin resistance. Although the total PGC-1alpha abundance in skeletal muscle was unaltered under static conditions, exercise-induced increases in total PGC-1alpha and energy expenditure were attenuated in the mutant mice. These results suggest that PGC-1alpha variants are responsible for exercise-induced PGC-1alpha upregulation, which in turn plays an important role in controlling fat mass and insulin sensitivity via the regulation of energy expenditure during exercise.
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Report
(3 results)
Research Products
(28 results)
